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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
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Journal ArticleDOI
NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma
Barry E. Kennedy,Michael Giacomantonio,J. Patrick Murphy,Samuel D. Cutler,Mary Ann E Sadek,Prathyusha Konda,Joao A. Paulo,Gopal P. Pathak,Saskia H.J. Renkens,Stacy Grieve,Jonathan Pol,Steven P. Gygi,Christopher Richardson,Daniel Gaston,Anthony Reiman,Guido Kroemer,Manal O. Elnenaei,Shashi Gujar +17 more
TL;DR: In this paper , the role of multiple myeloma metabolism in reovirus oncolysis was investigated using semi-targeted mass spectrometry-based metabolomics.
Fat cells directly sense temperature to activate
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Peer ReviewDOI
Author response: Scaffold-mediated gating of Cdc42 signalling flux
Péter Rapali,Romain Mitteau,Craig R. Braun,Aurelie Massoni-Laporte,Caner Ünlü,Laure Bataille,Floriane Saint Arramon,Steven P. Gygi,Derek McCusker +8 more
Journal ArticleDOI
Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas
Deyang Yu,Chi Luo,Christopher F. Bennett,Mark P. Jedrychowski,Steven P. Gygi,Hans R. Widlund,Pere Puigserver +6 more
TL;DR: In this paper , a metabolism-centered pharmacological screen further identifies statins (HMGCR inhibitors) as a collateral vulnerability within PGC1α-suppressed BRAF-inhibitor resistant melanomas.