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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Signaling networks assembled by oncogenic EGFR and c-Met
Ailan Guo,Judit Villén,Jon M. Kornhauser,Kimberly Lee,Matthew P. Stokes,Klarisa Rikova,Anthony Possemato,Julie Nardone,Gregory Innocenti,Randall K. Wetzel,Yi Wang,Joan MacNeill,Jeffrey Mitchell,Steven P. Gygi,John Rush,Roberto D. Polakiewicz,Michael J. Comb +16 more
TL;DR: Comparing non-small-cell lung cancer cell lines driven by EGFR-activating mutations and genomic amplifications using a global proteomic analysis of phospho-tyrosine signaling identifies an extensive receptor tyrosine kinase signaling network established in cells expressing mutated and activated EGFR or expressing amplified c-Met.
PatentDOI
Dual inhibition of sister chromatide separation at metaphase
TL;DR: It is proposed that separase activation at the metaphase-anaphase transition requires the removal of both securin and an inhibitory phosphate.
Journal ArticleDOI
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.
Hyoung Tae Kim,Kwang Pyo Kim,Kwang Pyo Kim,Fernando Lledías,Alexei F. Kisselev,K. Matthew Scaglione,Dorota Skowyra,Steven P. Gygi,Alfred L. Goldberg +8 more
TL;DR: It is found that the U-box E3, CHIP, and Ring finger E3s, MuRF1 and Mdm2, with the E2, UbcH5, form a novel type of Ub chain that contains all seven possible linkages, but predominantly Lys48, Lys63, and Lys11 linkages.
Journal ArticleDOI
Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry
Junmin Peng,Junmin Peng,Myung Jong Kim,Dongmei Cheng,Dongmei Cheng,Duc M. Duong,Steven P. Gygi,Morgan Sheng +7 more
TL;DR: A comprehensive analysis of purified PSD fractions by liquid chromatography coupled with tandem mass spectrometry reveals crucial information about molecular abundance as well as molecular diversity in the PSD, and provides a basis for further studies on the molecular mechanisms of synaptic function and plasticity.
Journal ArticleDOI
A molecular determinant for the establishment of sister chromatid cohesion.
Elçin Ünal,Jill M. Heidinger-Pauli,Jill M. Heidinger-Pauli,Woong Kim,Vincent Guacci,Itay Onn,Steven P. Gygi,Douglas Koshland +7 more
TL;DR: In budding yeast, the head domain of the Smc3p subunit of cohesin is acetylated by the Eco1p acetyltransferase at two evolutionarily conserved residues, promoting the chromatin-bound cohes in to tether sister chromatids.