S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Sample multiplexing for targeted pathway proteomics in aging mice
Qing Yu,Haopeng Xiao,Mark P. Jedrychowski,Devin K. Schweppe,José Navarrete-Perea,Jeffrey Knott,John C. Rogers,Edward T. Chouchani,Steven P. Gygi +8 more
TL;DR: Tissue-specific aging effects are presented and the role of inflammation- and metabolism-related processes in white adipose tissue is highlighted and Tomahto’s ease of use, sensitivity, and accuracy are highlighted.
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Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Nahid Iglesias,Mark A. Currie,Mark A. Currie,Gloria Jih,Gloria Jih,Joao A. Paulo,Nertila Siuti,Nertila Siuti,Marian Kalocsay,Steven P. Gygi,Danesh Moazed,Danesh Moazed +11 more
TL;DR: An autoinhibitory conformation in the conserved H3K9 methyltransferase Clr4 of the fission yeast Schizosaccharomyces pombe helps to prevent aberrant heterochromatin formation and maintains epigenetic stability.
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Proteomic insights into ubiquitin and ubiquitin-like proteins
TL;DR: A review of recent proteomic works targeting the dynamic and specific modification of cellular proteins by members of the ubiquitin protein family and their mechanisms of substrate specificity and enzymatic activity.
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A comparison of phenobarbital and codeine incorporation into pigmented and nonpigmented rat hair
TL;DR: The incorporation of a weak acid, phenobarbital, and a weak base, codeine, into Sprague-Dawley rat hair is examined to suggest that hair pigmentation greatly affects weak base incorporation but not weak acid incorporation into hair.
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Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets.
TL;DR: It is concluded that intramolecular phosphate transfer does not affect the reliability of current or past phosphorylation data sets, specifically for doubly charged species.