S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
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Journal ArticleDOI
Divergence of muscle and liver fructose 2,6-diphosphate in fasted exercising rats.
TL;DR: The increases in F-2,6,P2 and G-1,6-P2 may be important in accelerating glycolysis and enhancing lactate production in muscles that are not glycogen depleted during long-term exercise.
Book ChapterDOI
Towards an Integrated Analytical Technology for the Generation of Multidimensional Protein Expression Maps
Paul A. Haynes,David R. Goodlett,Steven P. Gygi,Julian D. Watts,Daniel Figeys,Reudi Aebersold +5 more
TL;DR: One of the most attractive features of such analyses is that complex biological systems can potentially be studied as complete systems, rather than as a conglomerate of individual components.
Journal ArticleDOI
Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50
Yue Sun,Xuelian Ning,Jiankun Fan,Jiandong Hu,Yanting Jiang,Ziqi Hu,Joao A. Paulo,Jichao Liu,Xiaohong Qiu,Hui Xu,Songbin Fu,Steven P. Gygi,Jinwei Zhang,Chunshui Zhou +13 more
TL;DR: Findings support a dual role of INPP4B in suppression of tumorigenesis by safeguarding genome stability, as well as inhibiting of PI3K-Akt-mTOR signaling, and offer a new therapeutic strategy for personalized cancer treatment to patients with INPP 4B defects or deficiency in the clinic.
Journal ArticleDOI
An expanded mouse testis transcriptome and mass spectrometry defines novel proteins.
Jaya Gamble,Joel M. Chick,Kelly Seltzer,Joel H Graber,Steven P. Gygi,Robert Braun,Elizabeth M Snyder +6 more
TL;DR: A more complete testis transcriptome generated by combining Tuxedo, a reductive method, and Spliced-RUM, a combinatorial transcript building approach is described, demonstrating the testis expresses a wide range of novel transcripts that give rise to novel proteins.