S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Daniel K. Bricker,Eric B. Taylor,John C. Schell,Thomas Orsak,Audrey Boutron,Yu-Chan Chen,James E. Cox,Caleb M. Cardon,Jonathan G. Van Vranken,Noah Dephoure,Claire Redin,Sihem Boudina,Steven P. Gygi,Michèle Brivet,Carl S. Thummel,Jared Rutter +15 more
TL;DR: Human genetic studies of three families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1, changing single amino acids that are conserved throughout eukaryotes, demonstrating that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier.
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Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Rajesh R. Rao,Jonathan Z. Long,James P. White,Katrin J. Svensson,Jesse Lou,Isha A. Lokurkar,Mark P. Jedrychowski,Jorge L. Ruas,Christiane D. Wrann,James C. Lo,Donny M. Camera,Jenn Lachey,Steven P. Gygi,Jasbir Seehra,John A. Hawley,Bruce M. Spiegelman +15 more
TL;DR: The identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure, which links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases.
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Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Bin Wang,Shuhei Matsuoka,Bryan A. Ballif,Bryan A. Ballif,Dong Zhang,Agata Smogorzewska,Steven P. Gygi,Stephen J. Elledge +7 more
TL;DR: Phosphopeptide affinity proteomic analysis identified a protein, Abraxas, that directly binds the BRCA1 BRCT repeats through a phospho-Ser-X- X-Phe motif, forming a third type of B RCA1 complex.
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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Agata Smogorzewska,Agata Smogorzewska,Shuhei Matsuoka,Patrizia Vinciguerra,E. Robert McDonald,Kristen E. Hurov,Ji Luo,Bryan A. Ballif,Steven P. Gygi,Kay Hofmann,Alan D. D'Andrea,Stephen J. Elledge +11 more
TL;DR: Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I, indicating the existence of a dual ubiquitin-locking mechanism required for ID complex function.
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SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Huai Xiang Hao,Oleh Khalimonchuk,Margit Schraders,Noah Dephoure,Jean-Pierre Bayley,Henricus P. M. Kunst,Peter Devilee,Cor W. R. J. Cremers,Joshua D. Schiffman,Brandon G. Bentz,Steven P. Gygi,Dennis R. Winge,Hannie Kremer,Jared Rutter +13 more
TL;DR: A combination of bioinformatics, yeast genetics, biochemistry, and human genetics was used to show that a previously uncharacterized mitochondrial protein (Sdh5) is required for the activity of respiratory complex II, leading to the discovery of a human tumor susceptibility gene.