T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Journal ArticleDOI
A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection
Mari Levula,Timo Paavonen,Timo Valo,Markku Pelto-Huikko,Reijo Laaksonen,Mika Kähönen,Ari Huovila,Terho Lehtimäki,Matti Tarkka,Ari Mennander +9 more
TL;DR: The involvement of ADAM8 and -15 together with inflammation consisting of B-cells may indicate active remodelling of the aortic wall leading to AD.
KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference
Gunter Schumann,Chunyu Liu,Paul F. O'Reilly,He Gao,Parkyong Song,Bing Xu,Barbara Ruggeri,Najaf Amin,Tianye Jia,Sarah R. Preis,Marcelo P. Segura Lepe,Shizuo Akira,Caterina Barbieri,Sebastian E. Baumeister,Stéphane Cauchi,Toni-Kim Clarke,Stefan Enroth,Krista Fischer,Jenni Hällfors,Sarah E. Harris,Saskia Hieber,Edith Hofer,Jouke-Jan Hottenga,Åsa Johansson,PeterK. Joshi,Niina E. Kaartinen,Jaana Laitinen,Rozenn N. Lemaitre,Anu Loukola,Jian'an Luan,Leo-Pekka Lyytikäinen,Massimo Mangino,Ani Manichaikul,Hamdi Mbarek,Yuri Milaneschi,Alireza Moayyeri,Kenneth J. Mukamal,Christopher P. Nelson,Jennifer A. Nettleton,Eemil Partinen,Rajesh Rawal,Antonietta Robino,Lynda M. Rose,Cinzia Sala,Takashi Satoh,Reinhold E. Schmidt,Katharina Schrautz,Robert A. Scott,Albert V. Smith,John M. Starr,Alexander Teumer,Stella Trompet,André G. Uitterlinden,Cristina Venturini,Anne-Claire Vergnaud,Niek Verweij,Veronique Vitart,Dragana Vuckovic,Juho Wedenoja,Loic Yengo,Bing Yu,Weihua Zhang,Jing Hua Zhao,Dorret I. Boomsma,John C. Chambers,Daniel I. Chasman,Toniolo Daniela,Eco J. C. de Geus,Ian J. Deary,Johan G. Eriksson,Tõnu Esko,Volker Eulenburg,Oscar H. Franco,Philippe Froguel,Christian Gieger,Hans J. Grabe,Vilmundur Gudnason,Ulf Gyllensten,Tamara B. Harris,Anna-Liisa Hartikainen,Andrew Heath,Lynne J. Hocking,Albert Hofman,Cornelia Huth,Marjo-Riitta Järvelin,J. Wouter Jukema,Jaakko Kaprio,Jaspal S. Kooner,Zoltán Kutalik,Jari Lahti,Claudia Langenberg,Terho Lehtimäki,Yongmei Liu,Pamela A. F. Madden,Nicholas G. Martin,Alanna C. Morrison,Brenda W.J.H. Penninx,Nicola Pirastu,Bruce M. Psaty,Olli T. Raitakari,Paul M. Ridker,Richard J. Rose,Jerome I. Rotter,Nilesh J. Samani,Helena Schmidt,Tim D. Spector,David J. Stott,David P. Strachan,Ioanna Tzoulaki,Pim van der Harst,Cornelia M. van Duijn,Pedro Marques-Vidal,Peter Vollenweider,Nicholas J. Wareham,John Whitfield,James F. Wilson,Bruce H. R. Wolffenbuttel,Georgy Bakalkin,Evangelos Evangelou,Yun Liu,Kenneth Rice,Sylvane Desrivières,Steven A. Kliewer,David J. Mangelsdorf,Christian P. Müller,Daniel Levy,Paul Elliott +126 more
TL;DR: In this paper, the authors performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking and found that a locus in the gene encoding β-Klotho is associated with alcohol consumption.
Journal ArticleDOI
The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness.
TL;DR: The results suggest that the interaction between dopaminergic and serotonergic genes might underlie impulsiveness and stress the importance of considering novelty seeking as a heterogeneous trait with its subscales having different genetic backgrounds.
Journal ArticleDOI
Impact of long-term hormone replacement therapy on in vivo and in vitro markers of lipid oxidation.
TL;DR: Estrogen and combined HRT do not differ in their abilities to oppose LDL oxidation in vitro or systemic oxidative stress in vivo, but have differential effects on blood lipids.
Journal ArticleDOI
Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts
Dariush Mozaffarian,Hassan S. Dashti,Mary K. Wojczynski,Audrey Y. Chu,Jennifer A. Nettleton,Satu Männistö,Kati Kristiansson,Magi Reedik,Jari Lahti,Denise K. Houston,Marilyn C. Cornelis,Frank J. A. van Rooij,Maria Dimitriou,Stavroula Kanoni,Vera Mikkilä,Vera Mikkilä,Lyn M. Steffen,Marcia C de Oliveira Otto,Lu Qi,Bruce M. Psaty,Luc Djoussé,Jerome I. Rotter,K. Harald,Markus Perola,Markus Perola,Markus Perola,Harri Rissanen,Antti Jula,Fischer Krista,Evelin Mihailov,Mary F. Feitosa,Julius S. Ngwa,Julius S. Ngwa,Luting Xue,Paul F. Jacques,Mia-Maria Perälä,Aarno Palotie,Yongmei Liu,Nike A. Nalls,Luigi Ferrucci,Dena G. Hernandez,Ani Manichaikul,Michael Y. Tsai,Jessica C. Kiefte-de Jong,Jessica C. Kiefte-de Jong,Albert Hofman,André G. Uitterlinden,Loukianos S. Rallidis,Paul M. Ridker,Paul M. Ridker,Lynda M. Rose,Julie E. Buring,Terho Lehtimäki,Mika Kähönen,Jorma Viikari,Rozenn N. Lemaitre,Veikko Salomaa,Paul Knekt,Andres Metspalu,Ingrid B. Borecki,L. Adrienne Cupples,L. Adrienne Cupples,Johan G. Eriksson,Johan G. Eriksson,Stephen B. Kritchevsky,Stefania Bandinelli,David S. Siscovick,Oscar H. Franco,Panos Deloukas,Panos Deloukas,George Dedoussis,Daniel I. Chasman,Olli T. Raitakari,Toshiko Tanaka +73 more
TL;DR: In this paper, the authors conducted a genome-wide association (GWA) meta-analysis of fish and EPA+DHA consumption in 17 cohorts of European descent from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium Nutrition Working Group.