T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Journal ArticleDOI
The polygenic and monogenic basis of blood traits and diseases
Dragana Vuckovic,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Peter W.F. Wilson,Hélène Choquet,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Qi Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,J. M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotios Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Kelly Cho,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Yukinori Okada,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo +113 more
TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.
Journal ArticleDOI
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Dan E. Arking,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Lia Crotti,Pim van der Harst,Patricia B. Munroe,Tamara T. Koopmann,Nona Sotoodehnia,Elizabeth J. Rossin,Elizabeth J. Rossin,Michael Morley,Xinchen Wang,Xinchen Wang,Andrew D. Johnson,Alicia Lundby,Alicia Lundby,Daniel F. Gudbjartsson,Peter A. Noseworthy,Peter A. Noseworthy,Mark Eijgelsheim,Yuki Bradford,Kirill Tarasov,Marcus Dörr,Martina Müller-Nurasyid,Annukka M. Lahtinen,Ilja M. Nolte,Albert V. Smith,Joshua C. Bis,Aaron Isaacs,Stephen Newhouse,Daniel S. Evans,Wendy S. Post,Daryl Waggott,Leo-Pekka Lyytikäinen,Andrew A. Hicks,Lewin Eisele,David Ellinghaus,Caroline Hayward,Pau Navarro,Sheila Ulivi,Toshiko Tanaka,David J. Tester,Stéphanie Chatel,Stefan Gustafsson,Stefan Gustafsson,Meena Kumari,Richard W Morris,Åsa Torinsson Naluai,Sandosh Padmanabhan,Alexander Kluttig,Bernhard Strohmer,Andrie G. Panayiotou,María Dolores Torres,Michael Knoflach,Jaroslav A. Hubacek,Kamil Slowikowski,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Runjun D. Kumar,Tamara B. Harris,Lenore J. Launer,Alan R. Shuldiner,Alan R. Shuldiner,Alvaro Alonso,Joel S. Bader,Georg Ehret,Hailiang Huang,Hailiang Huang,W. H. Linda Kao,James B. Strait,Peter W. Macfarlane,Morris Brown,Mark J. Caulfield,Nilesh J. Samani,Florian Kronenberg,Johann Willeit,J. Gustav Smith,J. Gustav Smith,J. Gustav Smith,Karin Halina Greiser,Karin Halina Greiser,Henriette E. Meyer zu Schwabedissen,Karl Werdan,Massimo Carella,Leopoldo Zelante,Susan R. Heckbert,Bruce M. Psaty,Bruce M. Psaty,Jerome I. Rotter,Ivana Kolcic,Ozren Polasek,Alan F. Wright,Maura Griffin,Mark J. Daly,Mark J. Daly,David O. Arnar,Hilma Holm,Unnur Thorsteinsdottir,Joshua C. Denny,Dan M. Roden,Rebecca L. Zuvich,Valur Emilsson,Andrew S. Plump,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Xiaoyan Yin,Xiaoyan Yin,Marco Bobbo,Adamo Pio D'Adamo,Annamaria Iorio,Gianfranco Sinagra,Angel Carracedo,Steven R. Cummings,Mike A. Nalls,Antti Jula,Kimmo Kontula,Annukka Marjamaa,Lasse Oikarinen,Markus Perola,Markus Perola,Markus Perola,Kimmo Porthan,Raimund Erbel,Per Hoffmann,Per Hoffmann,Karl-Heinz Jöckel,Hagen Kälsch,Markus M. Nöthen,Marcel den Hoed,Marcel den Hoed,Ruth J. F. Loos,Ruth J. F. Loos,Dag S. Thelle,Dag S. Thelle,Christian Gieger,Thomas Meitinger,Siegfried Perz,Annette Peters,Hanna Prucha,Moritz F. Sinner,Melanie Waldenberger,Rudolf A. de Boer,Lude Franke,Pieter A. van der Vleuten,Britt M. Beckmann,Eimo Martens,Abdennasser Bardai,Nynke Hofman,Arthur A.M. Wilde,Elijah R. Behr,Chrysoula Dalageorgou,John R. Giudicessi,Argelia Medeiros-Domingo,Julien Barc,Florence Kyndt,Vincent Probst,Alice Ghidoni,Roberto Insolia,Robert M. Hamilton,Stephen W. Scherer,Jeffrey Brandimarto,Kenneth B. Margulies,Christine E. Moravec,Fabiola Del Greco M,Christian Fuchsberger,Jeffrey R. O'Connell,Wai K. Lee,Graham Watt,Harry Campbell,Sarah H Wild,Nour Eddine El Mokhtari,Norbert Frey,Folkert W. Asselbergs,Folkert W. Asselbergs,Irene Mateo Leach,Gerjan Navis,Maarten P. van den Berg,Dirk J. van Veldhuisen,Manolis Kellis,Manolis Kellis,Bouwe P. Krijthe,Oscar H. Franco,Albert Hofman,Jan A. Kors,André G. Uitterlinden,Jacqueline C.M. Witteman,Lyudmyla Kedenko,Claudia Lamina,Ben A. Oostra,Gonçalo R. Abecasis,Edward G. Lakatta,Antonella Mulas,Marco Orru,David Schlessinger,Manuela Uda,Marcello Ricardo Paulista Markus,Uwe Völker,Harold Snieder,Tim D. Spector,Johan Ärnlöv,Johan Ärnlöv,Lars Lind,Johan Sundström,Ann-Christine Syvänen,Mika Kivimäki,Mika Kähönen,Nina Mononen,Olli T. Raitakari,Jorma S. A. Viikari,Vera Adamkova,Stefan Kiechl,Maria Brion,Andrew N. Nicolaides,Bernhard Paulweber,Johannes Haerting,Anna F. Dominiczak,Fredrik Nyberg,Fredrik Nyberg,Peter H. Whincup,Aroon D. Hingorani,Jean-Jacques Schott,Connie R. Bezzina,Erik Ingelsson,Erik Ingelsson,Luigi Ferrucci,Paolo Gasparini,James F. Wilson,Igor Rudan,Andre Franke,Thomas W. Mühleisen,Peter P. Pramstaller,Terho Lehtimäki,Andrew D. Paterson,Afshin Parsa,Yongmei Liu,Cornelia M. van Duijn,David S. Siscovick,Vilmundur Gudnason,Yalda Jamshidi,Veikko Salomaa,Stephan B. Felix,Serena Sanna,Marylyn D. Ritchie,Bruno H. Stricker,Kari Stefansson,Laurie A. Boyer,Thomas P. Cappola,Jesper V. Olsen,Kasper Lage,Peter J. Schwartz,Stefan Kääb,Aravinda Chakravarti,Michael J. Ackerman,Arne Pfeufer,Paul I.W. de Bakker,Christopher Newton-Cheh,Christopher Newton-Cheh +260 more
TL;DR: In this paper, the authors identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization.
Journal ArticleDOI
Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
Peter Würtz,Qin Wang,Antti J. Kangas,Rebecca C Richmond,Joni Skarp,Mika Tiainen,Tuulia Tynkkynen,Pasi Soininen,Aki S. Havulinna,Marika Kaakinen,Jorma Viikari,Markku J. Savolainen,Mika Kähönen,Terho Lehtimäki,Satu Männistö,Stefan Blankenberg,Tanja Zeller,Jaana Laitinen,Anneli Pouta,Pekka Mäntyselkä,Mauno Vanhala,Paul Elliott,Kirsi H. Pietiläinen,Samuli Ripatti,Veikko Salomaa,Olli T. Raitakari,Marjo-Riitta Järvelin,George Davey Smith,Mika Ala-Korpela +28 more
TL;DR: To what extent elevated body mass index within the normal weight range has causal influences on the detailed systemic metabolite profile in early adulthood using Mendelian randomization analysis is investigated.
Journal ArticleDOI
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
Päivi Pajukanta,Ilpo Nuotio,Joseph D. Terwilliger,Kimmo Porkka,Kati Ylitalo,Jussi Pihlajamäki,Aki J. Suomalainen,Ann-Christine Syvänen,Terho Lehtimäki,Jorma Viikari,Markku Laakso,Marja-Riitta Taskinen,Christian Ehnholm,Leena Peltonen +13 more
TL;DR: The identification of a mouse combined hyperlipidaemia locus in the syntenic region of the mouse genome is reported, thus further implicating a gene in this region in the aetiology of FCHL.
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmueller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Jennie Hui,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Christer Janson,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Ashok Kumar,Mikko Kuokkanen,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +174 more