T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Defining the role of common variation in the genomic and biological architecture of adult human height
Andrew R. Wood,Tõnu Esko,Jian Yang,Sailaja Vedantam,Tune H. Pers,Stefan Gustafsson,Audrey Y. Chun,Karol Estrada,Jian'an Luan,Zoltán Kutalik,Najaf Amin,Martin L. Buchkovich,Damien C. Croteau-Chonka,Felix R. Day,Yanan Duan,Tove Fall,Rudolf S N Fehrmann,Teresa Ferreira,Anne U. Jackson,Juha Karjalainen,Ken Sin Lo,Adam E. Locke,Reedik Maegi,Evelin Mihailov,Eleonora Porcu,Joshua C. Randall,André Scherag,Anna A. E. Vinkhuyzen,Harm-Jan Westra,Thomas W. Winkler,Tsegaselassie Workalemahu,Jing Hua Zhao,Devin Absher,Eva Albrecht,Denise Anderson,Jeffrey Baron,Marian Beekman,Ayse Demirkan,Georg Ehret,Bjarke Feenstra,Mary F. Feitosa,Krista Fischer,Ross M. Fraser,Anuj Goel,Jian Gong,Anne E. Justice,Stavroula Kanoni,Marcus E. Kleber,Kati Kristiansson,Unhee Lim,Vaneet Lotay,Julian C. Lui,Massimo Mangino,Irene Mateo Leach,Carolina Medina-Gomez,Mike A. Nalls,Dale R. Nyholt,Cameron D. Palmer,Dorota Pasko,Sonali Pechlivanis,Inga Prokopenko,Janina S. Ried,Stephan Ripke,Dmitry Shungin,Alena Stančáková,Rona J. Strawbridge,Yun Ju Sung,Toshiko Tanaka,Alexander Teumer,Stella Trompet,Sander W. van der Laan,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Zhaoming Wang,Loic Yengo,Weihua Zhang,Uzma Afzal,Johan Arnloev,Gillian M. Arscott,Stefania Bandinelli,Amy Barrett,Claire Bellis,Amanda J. Bennett,Christian Berne,Matthias Blueher,Jennifer L. Bolton,Yvonne Boettcher,Heather A. Boyd,Marcel Bruinenberg,Brendan M. Buckley,Steven Buyske,Ida Henriette Caspersen,Peter S. Chines,Robert Clarke,Simone Claudi-Boehm,Mark E. Cooper,E. Warwick Daw,Pim A. de Jong,Joris Deelen,Graciela E. Delgado,Josh C. Denny,Rosalie A. M. Dhonukshe-Rutten,Maria Dimitriou,Alex S. F. Doney,Marcus Doerr,Niina Eklund,Elodie Eury,Lasse Folkersen,Melissa E. Garcia,Frank Geller,Vilmantas Giedraitis,Alan S. Go,Harald Grallert,Tanja B. Grammer,Juergen Graessler,Henrik Groenberg,Lisette C. P. G. M. de Groot,Christopher J. Groves,Jeffrey Haessler,Per Hall,Toomas Haller,Göran Hallmans,Anke Hannemann,Catharina A. Hartman,Maija Hassinen,Caroline Hayward,Nancy L. Heard-Costa,Quinta Helmer,Gibran Hemani,Anjali K. Henders,Hans L. Hillege,Mark A. Hlatky,Wolfgang Hoffmann,Per Hoffmann,Oddgeir L. Holmen,Jeanine J. Houwing-Duistermaat,Thomas Illig,Aaron Isaacs,Alan L. James,Janina M. Jeff,Bent Johansen,Åsa Johansson,Jennifer Jolley,Thorhildur Juliusdottir,Juhani Junttila,Abel N. Kho,Leena Kinnunen,Norman Klopp,Thomas D. Kocher,Wolfgang Kratzer,Peter Lichtner,Lars Lind,Jaana Lindstroem,Stéphane Lobbens,Mattias Lorentzon,Yingchang Lu,Valeriya Lyssenko,Patrik K. E. Magnusson,Anubha Mahajan,Marc Maillard,Wendy L. McArdle,Colin A. McKenzie,Stela McLachlan,Paul J. McLaren,Cristina Menni,Sigrun Merger,Lili Milani,Alireza Moayyeri,Keri L. Monda,Mario A. Morken,Gabriele Mueller,Martina Mueller-Nurasyid,Arthur W. Musk,Narisu Narisu,Matthias Nauck,Ilja M. Nolte,Markus M. Noethen,Laticia Oozageer,Stefan Pilz,Nigel W. Rayner,Frida Renström,Neil R. Robertson,Lynda M. Rose,Ronan Roussel,Serena Sanna,Hubert Scharnagl,Salome Scholtens,Fredrick R. Schumacher,Heribert Schunkert,Robert A. Scott,Joban Sehmi,Thomas Seufferlein,Jianxin Shin,Karri Silventoinen,Johannes H. Smit,Albert V. Smith,Joanna Smolonska,Alice Stanton,Kathleen Stirrups,David J. Stott,Heather M. Stringham,Johan Sundström,Morris A. Swertz,Ann-Christine Syvänen,Bamidele O. Tayo,Gudmar Thorleifsson,Jonathan Tyrer,Suzanne C. van Dijk,Natasja M. van Schoor,Nathalie van der Velde,Diana van Heemst,Floor V. A. van Oort,Sita H. Vermeulen,Niek Verweij,Judith M. Vonk,Lindsay L. Waite,Melanie Waldenberger,Roman Wennauer,Lynne R. Wilkens,Christina Willenborg,Tom Wilsgaard,Mary K. Wojczynski,Andrew Wong,Alan F. Wright,Qunyuan Zhang,Dominique Arveiler,Stephan J. L. Bakker,John Beilby,Richard N. Bergman,Sven Bergmann,Reiner Biffar,John Blangero,Dorret I. Boomsma,Stefan R. Bornstein,Pascal Bovet,Paolo Brambilla,Morris J. Brown,Harry Campbell,Mark J. Caulfield,Aravinda Chakravarti,Rory Collins,Francis S. Collins,Dana C. Crawford,L. Adrienne Cupples,John Danesh,Ulf de Faire,Hester M. den Ruijter,Raimund Erbel,Jeanette Erdmann,Johan G. Eriksson,Martin Farrall,Ele Ferrannini,Jean Ferrières,Ian Ford,Nita G. Forouhi,Terrence Forrester,Ron T. Gansevoort,Pablo V. Gejman,Christian Gieger,Alain Golay,Omri Gottesman,Vilmundur Gudnason,Ulf Gyllensten,David W. Haas,Alistair S. Hall,Tamara B. Harris,Andrew T. Hattersley,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Lucia A. Hindorff,Aroon D. Hingorani,Albert Hofman,G. Kees Hovingh,Steve E. Humphries,Steven C. Hunt,Elina Hyppönen,Kevin B. Jacobs,Marjo-Riitta Järvelin,Pekka Jousilahti,Antti Jula,Jaakko Kaprio,John J.P. Kastelein,Manfred Kayser,Frank Kee,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Jaspal S. Kooner,Charles Kooperberg,Seppo Koskinen,Peter Kovacs,Aldi T. Kraja,Meena Kumari,Johanna Kuusisto,Timo A. Lakka,Claudia Langenberg,Loic Le Marchand,Terho Lehtimäki,Sara Lupoli,Pamela A. F. Madden,Satu Männistö,Paolo Manunta,André Marette,Tara C. Matise,Barbara McKnight,Thomas Meitinger,Frans L. Moll,Grant W. Montgomery,Andrew D. Morris,Andrew P. Morris,Jeffrey C. Murray,Mari Nelis,Claes Ohlsson,Albertine J. Oldehinkel,Ken K. Ong,Willem H. Ouwehand,Gerard Pasterkamp,Annette Peters,Peter P. Pramstaller,Jackie F. Price,Lu Qi,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Treva Rice,Marylyn D. Ritchie,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Jouko Saramies,Mark A. Sarzynski,Peter Schwarz,Sylvain Sebert,Peter S. Sever,Alan R. Shuldiner,Juha Sinisalo,Valgerdur Steinthorsdottir,Ronald P. Stolk,Jean-Claude Tardif,Anke Toenjes,Angelo Tremblay,Elena Tremoli,Jarmo Virtamo,Marie-Claude Vohl,Philippe Amouyel,Folkert W. Asselbergs,Themistocles L. Assimes,Murielle Bochud,Bernhard O. Boehm,Eric Boerwinkle,Erwin P. Bottinger,Claude Bouchard,Stéphane Cauchi,John C. Chambers,Stephen J. Chanock,Richard S. Cooper,Paul I.W. de Bakker,George Dedoussis,Luigi Ferrucci,Paul W. Franks,Philippe Froguel,Leif Groop,Christopher A. Haiman,Anders Hamsten,M. Geoffrey Hayes,Jennie Hui,David J. Hunter,Kristian Hveem,J. Wouter Jukema,Robert C. Kaplan,Mika Kivimäki,Diana Kuh,Markku Laakso,Yongmei Liu,Nicholas G. Martin,Winfried Maerz,Mads Melbye,Susanne Moebus,Patricia B. Munroe,Inger Njølstad,Ben A. Oostra,Colin N. A. Palmer,Nancy L. Pedersen,Markus Perola,Louis Pérusse,Ulrike Peters,Joseph E. Powell,Chris Power,Thomas Quertermous,Rainer Rauramaa,Eva Reinmaa,Paul M. Ridker,Fernando Rivadeneira,Jerome I. Rotter,Timo Saaristo,Danish Saleheen,David Schlessinger,P. Eline Slagboom,Harold Snieder,Tim D. Spector,Konstantin Strauch,Michael Stumvoll,Jaakko Tuomilehto,Matti Uusitupa,Pim van der Harst,Henry Voelzke,Mark Walker,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Pieter Zanen,Panos Deloukas,Iris M. Heid,Cecilia M. Lindgren,Karen L. Mohlke,Elizabeth K. Speliotes,Unnur Thorsteinsdottir,Inês Barroso,Caroline S. Fox,Kari E. North,David P. Strachan,Jacques S. Beckmann,Sonja I. Berndt,Michael Boehnke,Ingrid B. Borecki,Mark I. McCarthy,Andres Metspalu,Kari Stefansson,André G. Uitterlinden,Cornelia M. van Duijn,Lude Franke,Cristen J. Willer,Alkes L. Price,Guillaume Lettre,Ruth J. F. Loos,Michael N. Weedon,Erik Ingelsson,Jeffrey R. O'Connell,Gonçalo R. Abecasis,Daniel I. Chasman,Michael E. Goddard,Peter M. Visscher,Joel N. Hirschhorn,Timothy M. Frayling +444 more
TL;DR: The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Journal ArticleDOI
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales
Karin J. H. Verweij,Karin J. H. Verweij,Jari Lahti,Eliza Congdon,Jesper Ekelund,Mirka Hintsanen,Katri Räikkönen,Terho Lehtimäki,Mika Kähönen,E. Widen,Anja Taanila,Johanna Veijola,A. C. Heath,Pamela A. F. Madden,Grant W. Montgomery,Chiara Sabatti,M-R Jarvelin,Aarno Palotie,Olli T. Raitakari,Olli T. Raitakari,Jorma Viikari,Jorma Viikari,Nicholas G. Martin,Johan G. Eriksson,Liisa Keltikangas-Järvinen,Naomi R. Wray,Nelson B. Freimer,Nelson B. Freimer +27 more
TL;DR: In this paper, the authors used item response theory to identify genome-wide significant loci (P<1.25 × 10−8) for each of the four temperament dimensions.
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Nora Franceschini,Claudia Giambartolomei,P. De Vries,Chris Finan,J. C. Bis,Rachael P. Huntley,Ruth C. Lovering,Salman M. Tajuddin,Thomas W. Winkler,Misa Graff,Maryam Kavousi,Caroline Dale,Albert V. Smith,Edith Hofer,E. C. M. van Leeuwen,Ilja M. Nolte,L Lu,Markus Scholz,Muralidharan Sargurupremraj,Niina Pitkänen,Oscar Franzén,Peter K. Joshi,Raymond Noordam,Riccardo E. Marioni,Hwang S-J.,Solomon K. Musani,Ulf Schminke,Walter Palmas,Aaron Isaacs,Adolfo Correa,Alan B. Zonderman,Albert Hofman,Alexander Teumer,Amanda J. Cox,André G. Uitterlinden,Andrew Wong,Andries J. Smit,Anne B. Newman,Annie Britton,Arno Ruusalepp,Bengt Sennblad,Bo Hedblad,Bogdan Pasaniuc,Brenda W.J.H. Penninx,Carl D. Langefeld,Christina L. Wassel,Christophe Tzourio,Cristiano Fava,Cristiano Fava,Damiano Baldassarre,Daniel H. O'Leary,Daniel Teupser,Diana Kuh,Elena Tremoli,Elmo Mannarino,Enzo Grossi,Eric Boerwinkle,Eric Boerwinkle,Eric E. Schadt,Erik Ingelsson,Fabrizio Veglia,Fernando Rivadeneira,Frank Beutner,Ganesh Chauhan,Ganesh Chauhan,Gerardo Heiss,Harold Snieder,Harry Campbell,Henry Völzke,Hugh S. Markus,Ian J. Deary,Joop Jukema,J. de Graaf,Jenna Price,Janne Pott,Jemma C. Hopewell,Jingjing Liang,Joachim Thiery,Jorgen Engmann,Karl Gertow,Kenneth Rice,Kent D. Taylor,Klodian Dhana,Kiemeney Lalm.,Lars Lind,Laura M. Raffield,Lenore J. Launer,Lesca M. Holdt,Lesca M. Holdt,Marcus Dörr,Martin Dichgans,Matthew Traylor,Matthias Sitzer,Meena Kumari,Meena Kumari,Mika Kivimäki,Mike A. Nalls,Olle Melander,Olli T. Raitakari,Olli T. Raitakari,Oscar H. Franco,Oscar H. Franco,Oscar L. Rueda-Ochoa,Oscar L. Rueda-Ochoa,Panos Roussos,Panos Roussos,Peter H. Whincup,P. Amouyel,P. Giral,P Anugu,Quenna Wong,Rainer Malik,Rainer Rauramaa,Ralph Burkhardt,Ralph Burkhardt,Rebecca Hardy,Reinhold Schmidt,R. de Mutsert,Richard W Morris,Rona J. Strawbridge,Rona J. Strawbridge,SG Wannamethee,Sara Hägg,Sonia Shah,Stela McLachlan,Stella Trompet,Sudha Seshadri,Sudhir Kurl,Susan R. Heckbert,Susan R. Heckbert,Susan M. Ring,T.B. Harris,Terho Lehtimäki,Tessel E. Galesloot,Tina Shah,U de Faire,Vincent Plagnol,Wayne D. Rosamond,Wendy S. Post,Xiaofeng Zhu,Xiaoling Zhang,Xuejiang Guo,Yasaman Saba,Abbas Dehghan,Abbas Dehghan,A Seldenrijk,A C Morrison,Anders Hamsten,Bruce M. Psaty,C.M. van Duijn,Debbie A Lawlor,Dennis O. Mook-Kanamori,Donald W. Bowden,Helena Schmidt,James F. Wilson,James G. Wilson,Jerome I. Rotter,Joanna M. Wardlaw,John E. Deanfield,Julian Halcox,Lyytikäinen L-P.,Markus Loeffler,Michelle K. Evans,Stéphanie Debette,S.E. Humphries,Uwe Völker,Vilmundur Gudnason,Aroon D. Hingorani,Björkegren Jlm.,Juan P. Casas,Christopher J. O'Donnell +170 more
TL;DR: The authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and stroke.
Journal ArticleDOI
Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression.
Sami Anttila,Kaija Huuhka,Martti Huuhka,Riikka Rontu,Mikko Hurme,Esa Leinonen,Terho Lehtimäki +6 more
TL;DR: It is shown that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression and the combination of 5- HT1A GG and BD NF GA + AA genotypes is associated with an increased risk of depression.
Journal Article
Evaluation of plasma cystatin C as a marker for glomerular filtration rate in patients with type 2 diabetes.
Aimo Harmoinen,T. T. Kouri,Ole Wirta,Terho Lehtimäki,Vappu Rantalaiho,Väinö Turjanmaa,Amos Pasternack +6 more
TL;DR: Cystatin C measurement is a more sensitive and specific test for GFR in patients with type 2 diabetes than plasma creatinine or its clearance, when GFR is normal or only slightly reduced.