T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Genome-wide associations for birth weight and correlations with adult disease
Momoko Horikoshi,Robin N Beaumont,Felix R. Day,Nicole M. Warrington,Marjolein N. Kooijman,Juan Fernández-Tajes,Bjarke Feenstra,Natalie R. van Zuydam,Kyle J. Gaulton,Niels Grarup,Jonathan P. Bradfield,David P. Strachan,Ruifang Li-Gao,Tarunveer S. Ahluwalia,Eskil Kreiner,Rico Rueedi,Leo-Pekka Lyytikäinen,Diana L. Cousminer,Ying Wu,Elisabeth Thiering,Carol A. Wang,Christian Theil Have,Jouke-Jan Hottenga,Natalia Vilor-Tejedor,Peter K. Joshi,Eileen Tai-Hui Boh,Ioanna Ntalla,Niina Pitkänen,Anubha Mahajan,Elisabeth M. van Leeuwen,Raimo Joro,Vasiliki Lagou,Michael Nodzenski,Louise A. Diver,Krina T. Zondervan,Mariona Bustamante,Pedro Marques-Vidal,Josep M. Mercader,Amanda J. Bennett,Nilufer Rahmioglu,Dale R. Nyholt,Ronald C.W. Ma,Claudia H. T. Tam,Wing Hung Tam,Santhi K. Ganesh,Frank J. A. van Rooij,Samuel E. Jones,Po-Ru Loh,Katherine S. Ruth,Marcus A. Tuke,Jessica Tyrrell,Andrew R. Wood,Hanieh Yaghootkar,Denise M. Scholtens,Lavinia Paternoster,Inga Prokopenko,Peter Kovacs,Mustafa Atalay,Sara M. Willems,Kalliope Panoutsopoulou,Xu Wang,Lisbeth Carstensen,Frank Geller,Katharina E. Schraut,Mario Murcia,Catharina E. M. van Beijsterveldt,Gonneke Willemsen,Emil V. R. Appel,Cilius Esmann Fonvig,Cæcilie Trier,Carla M. T. Tiesler,Marie Standl,Zoltán Kutalik,Sílvia Bonàs-Guarch,David M. Hougaard,Friman Sánchez,David Torrents,Johannes Waage,Mads V. Hollegaard,Hugoline G. de Haan,Frits R. Rosendaal,Carolina Medina-Gomez,Susan M. Ring,Gibran Hemani,George McMahon,Neil R. Robertson,Christopher J. Groves,Claudia Langenberg,Jian'an Luan,Robert A. Scott,Jing Hua Zhao,Frank D. Mentch,Scott M. MacKenzie,Rebecca M. Reynolds,William L. Lowe,Anke Toenjes,Michael Stumvoll,Virpi Lindi,Timo A. Lakka,Cornelia M. van Duijn,Wieland Kiess,Antje Koerner,Thorkild I. A. Sørensen,Harri Niinikoski,Katja Pahkala,Olli T. Raitakari,Eleftheria Zeggini,George Dedoussis,Yik Ying Teo,Seang-Mei Saw,Mads Melbye,Harry Campbell,James F. Wilson,Martine Vrijheid,Eco J. C. de Geus,Dorret I. Boomsma,Haja N. Kadarmideen,Jens-Christian Holm,Torben Hansen,Sylvain Sebert,Andrew T. Hattersley,Lawrence J. Beilin,John P. Newnham,Craig E. Pennell,Joachim Heinrich,Linda S. Adair,Judith B. Borja,Karen L. Mohlke,Johan G. Eriksson,Elisabeth Widen,Mika Kähönen,Jorma Viikari,Terho Lehtimäki,Peter Vollenweider,Klaus Bønnelykke,Hans Bisgaard,Dennis O. Mook-Kanamori,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Charlotta Pisinger,Oluf Pedersen,Christine Power,Elina Hyppoenen,Nicholas J. Wareham,Hakon Hakonarson,Eleanor Davies,Brian R. Walker,Vincent W. V. Jaddoe,Marjo-Riitta Jaervelin,Struan F.A. Grant,Allan Vaag,Debbie A Lawlor,Timothy M. Frayling,George Davey Smith,Andrew P. Morris,Ken K. Ong,Janine F. Felix,Nicholas J. Timpson,John R. B. Perry,David M. Evans,Mark I. McCarthy,Rachel M. Freathy +162 more
Journal ArticleDOI
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Symen Ligthart,Ahmad Vaez,Urmo Võsa,Maria G. Stathopoulou,P. De Vries,Bram P. Prins,P. J. van der Most,Toshiko Tanaka,Elnaz Naderi,Lynda M. Rose,Ying Wu,Robert Karlsson,Maja Barbalić,Honghuang Lin,René Pool,Gu Zhu,Aurélien Macé,C Sidore,Stella Trompet,Massimo Mangino,Maria Sabater-Lleal,John P. Kemp,Ali Abbasi,Tim Kacprowski,Niek Verweij,Albert V. Smith,Tao Huang,Carola Marzi,Mary F. Feitosa,Kurt Lohman,Marcus E. Kleber,Yuri Milaneschi,Christine M. Mueller,M Huq,Efthymia Vlachopoulou,Lyytikäinen L-P.,Christopher Oldmeadow,Joris Deelen,Markus Perola,Jing Hua Zhao,Bjarke Feenstra,Marzyeh Amini,Jari Lahti,Katharina E. Schraut,Myriam Fornage,Bhoom Suktitipat,Chen W-M.,Xiaohui Li,Teresa Nutile,Giovanni Malerba,Jian'an Luan,Tom Bak,Nicholas J. Schork,Elisabeth Thiering,Anubha Mahajan,Riccardo E. Marioni,Evelin Mihailov,Joel Eriksson,Ayse Bilge Ozel,Weihua Zhang,Maria Nethander,Cheng Y-C.,Stella Aslibekyan,Wei Ang,Ilaria Gandin,Loic Yengo,Laura Portas,Charles Kooperberg,Edith Hofer,Kumar B. Rajan,Claudia Schurmann,W. den Hollander,Tarunveer S. Ahluwalia,Jing Zhao,Draisma Hhm.,Ian Ford,Nicholas J. Timpson,Alexander Teumer,Hongyan Huang,Simone Wahl,Yongmei Liu,Jinyan Huang,Uh H-W.,Frank Geller,Peter K. Joshi,Lisa R. Yanek,Elisabetta Trabetti,Benjamin Lehne,Diego Vozzi,M Verbanck,Ginevra Biino,Yasaman Saba,Ingrid Meulenbelt,Jeffery R. O'Connell,Markku Laakso,Franco Giulianini,Magnusson Pke.,Christie M. Ballantyne,J-J Hottenga,Grant W. Montgomery,Fernando Rivadineira,Rico Rueedi,Maristella Steri,Herzig K-H.,David J. Stott,Cristina Menni,Mattias Frånberg,B. St Pourcain,Stephan B. Felix,Tune H. Pers,Bakker Sjl.,Peter Kraft,Annette Peters,Dhananjay Vaidya,Graciela Delgado,Jan H. Smit,V Großmann,Juha Sinisalo,Ilkka Seppälä,Stephen R. Williams,Elizabeth G. Holliday,Matthijs Moed,Claudia Langenberg,Katri Räikkönen,Jun Ding,Harry Campbell,Michèle M. Sale,Chen Y-Di.,Chen Y-Di.,Alan James,Daniela Ruggiero,Nicole Soranzo,Catharina A. Hartman,Erin N. Smith,Gerald S. Berenson,Christian Fuchsberger,Dena G. Hernandez,Tiesler Cmt.,Vilmantas Giedraitis,D C Liewald,Krista Fischer,Dan Mellström,Anders Larsson,Yajuan Wang,William R. Scott,Mattias Lorentzon,John Beilby,Kathleen A. Ryan,Craig E. Pennell,Dragana Vuckovic,Beverley Balkau,Maria Pina Concas,Reinhold Schmidt,C. F. Mendes de Leon,C. F. Mendes de Leon,Erwin P. Bottinger,Margreet Kloppenburg,Lavinia Paternoster,Michael Boehnke,Arthur W. Musk,Gonneke Willemsen,David M. Evans,Madden Paf.,Mika Kähönen,Zoltán Kutalik,Magdalena Zoledziewska,Ville Karhunen,Stephen B. Kritchevsky,Naveed Sattar,Genevieve Lachance,Robert Clarke,T.B. Harris,Olli T. Raitakari,John Attia,D. van Heemst,Eero Kajantie,Rossella Sorice,Giovanni Gambaro,Robert A. Scott,Andrew A. Hicks,Luigi Ferrucci,M. Standl,Cecilia M. Lindgren,John M. Starr,Magnus Karlsson,Lars Lind,Jun Li,John C. Chambers,Trevor A. Mori,de Geus Ejcn.,A. C. Heath,Nicholas G. Martin,Juha Auvinen,Brendan M. Buckley,de Craen Ajm.,M. Waldenberger,Konstantin Strauch,Thomas Meitinger,R. J. Scott,Mark McEvoy,Marian Beekman,Cristina Bombieri,Paul M. Ridker,Karen L. Mohlke,Nancy L. Pedersen,A C Morrison,Dorret I. Boomsma,John Whitfield,David P. Strachan,Albert Hofman,Peter Vollenweider,Francesco Cucca,Jarvelin M-R.,Joop Jukema,Tim D. Spector,Anders Hamsten,Tanja Zeller,André G. Uitterlinden,Matthias Nauck,Vilmundur Gudnason,Lu Qi,H Grallert,Ingrid B. Borecki,Jerome I. Rotter,W. März,Philipp S. Wild,Lokki M-L.,Michael Boyle,Veikko Salomaa,Mads Melbye,Johan G. Eriksson,James F. Wilson,Penninx Bwjh.,Diane M. Becker,B. B. Worrall,Greg Gibson,Ronald M. Krauss,Marina Ciullo,Gianluigi Zaza,Nicholas J. Wareham,Albertine J. Oldehinkel,Lyle J. Palmer,Sarah S. Murray,Peter P. Pramstaller,Stefania Bandinelli,Joachim Heinrich,Erik Ingelsson,Ian J. Deary,Reedik Mägi,Liesbeth Vandenput,P. van der Harst,Karl C. Desch,Jaspal S. Kooner,Claes Ohlsson,Caroline Hayward,Terho Lehtimäki,Alan R. Shuldiner,Donna K. Arnett,Lawrie J. Beilin,Antonietta Robino,Philippe Froguel,Mario Pirastu,T. Jess,Wolfgang Koenig,Loos Rjf.,Denis A. Evans,Helena Schmidt,George Davey Smith,P E Slagboom,Gudny Eiriksdottir,Andrew P. Morris,Bruce M. Psaty,Russel Tracy,Ilja M. Nolte,Eric Boerwinkle,Sophie Visvikis-Siest,Alexander P. Reiner,Myron D. Gross,J. C. Bis,Lude Franke,Oscar H. Franco,E J Benjamin,Daniel I. Chasman,Josée Dupuis,Harold Snieder,Abbas Dehghan,Behrooz Z. Alizadeh +286 more
TL;DR: In this article, the authors performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Matthias Wuttke,Yong Li,Man Li,Karsten B. Sieber,Mary F. Feitosa,Mathias Gorski,Adrienne Tin,Lihua Wang,Audrey Y. Chu,Anselm Hoppmann,Holger Kirsten,Ayush Giri,Jin-Fang Chai,Gardar Sveinbjornsson,Bamidele O. Tayo,Teresa Nutile,Christian Fuchsberger,Jonathan Marten,Massimiliano Cocca,Sahar Ghasemi,Yizhe Xu,Katrin Horn,Damia Noce,Peter J. van der Most,Sanaz Sedaghat,Zhi Yu,Masato Akiyama,Saima Afaq,Tarunveer S. Ahluwalia,Peter Almgren,Najaf Amin,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Michael Boehnke,Eric Boerwinkle,Mathilde Boissel,Erwin P. Bottinger,Thibaud Boutin,Hermann Brenner,Marco Brumat,Ralph Burkhardt,Adam S. Butterworth,Eric Campana,Archie Campbell,Harry Campbell,Mickaël Canouil,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Miao-Ling Chee,Miao-Li Chee,Xu Chen,Ching-Yu Cheng,Yurong Cheng,Kaare Christensen,Renata Cifkova,Marina Ciullo,Maria Pina Concas,James P. Cook,Josef Coresh,Tanguy Corre,Cinzia Sala,Daniele Cusi,John Danesh,E. Warwick Daw,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Frauke Degenhardt,Graciela E. Delgado,Ayse Demirkan,Emanuele Di Angelantonio,Katalin Dittrich,Jasmin Divers,Rajkumar Dorajoo,Kai-Uwe Eckardt,Georg Ehret,Paul Elliott,Karlhans Endlich,Michele K. Evans,Janine F. Felix,Valencia Hui Xian Foo,Oscar H. Franco,Andre Franke,Barry I. Freedman,Sandra Freitag-Wolf,Yechiel Friedlander,Philippe Froguel,Ron T. Gansevoort,He Gao,Paolo Gasparini,J. Michael Gaziano,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Franco Giulianini,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Catharina A. Hartman,Caroline Hayward,Jacklyn N. Hellwege,Chew-Kiat Heng,Andrew A. Hicks,Edith Hofer,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Olafur S. Indridason,Erik Ingelsson,Marcus Ising,Vincent W. V. Jaddoe,Johanna Jakobsdottir,Jost B. Jonas,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Candace M. Kammerer,Masahiro Kanai,Mika Kastarinen,Shona M. Kerr,Chiea Chuen Khor,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Aldi T. Kraja,Alena Krajčoviechová,Holly Kramer,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Mikko Kuokkanen,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Leslie A. Lange,Carl D. Langefeld,Jeannette Lee,Benjamin Lehne,Terho Lehtimäki,Wolfgang Lieb,Su Chi Lim,Lars Lind,Cecilia M. Lindgren,Jun Liu,Jianjun Liu,Markus Loeffler,Ruth J. F. Loos,Susanne Lucae,Mary Ann Lukas,Leo-Pekka Lyytikäinen,Reedik Mägi,Patrik K. E. Magnusson,Anubha Mahajan,Nicholas G. Martin,Jade Martins,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Olle Melander,Andres Metspalu,Evgenia K. Mikaelsdottir,Yuri Milaneschi,Kozeta Miliku,Pashupati P. Mishra,VA Million Veteran Program,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Josyf C. Mychaleckyj,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Michelle L. O'Donoghue,Isleifur Olafsson,Albertine J. Oldehinkel,Marju Orho-Melander,Willem H. Ouwehand,Sandosh Padmanabhan,Nicholette D. Palmer,Runolfur Palsson,Brenda W.J.H. Penninx,Thomas T. Perls,Markus Perola,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Anna I. Podgornaia,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Peter P. Pramstaller,Michael Preuss,Bram P. Prins,Michael A. Province,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Dermot F. Reilly,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Paul M. Ridker,Fernando Rivadeneira,Federica Rizzi,David J. Roberts,Antonietta Robino,Peter Rossing,Igor Rudan,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Charumathi Sabanayagam,Veikko Salomaa,Erika Salvi,Kai-Uwe Saum,Helena Schmidt,Reinhold Schmidt,Ben Schöttker,Christina-Alexandra Schulz,Nicole Schupf,Christian M. Shaffer,Yuan Shi,Albert V. Smith,Blair H. Smith,Nicole Soranzo,Cassandra N. Spracklen,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Per Svensson,Silke Szymczak,E-Shyong Tai,Salman M. Tajuddin,Nicholas Y. Q. Tan,Kent D. Taylor,Andrej Teren,Yih Chung Tham,Joachim Thiery,Chris H. L. Thio,Hauke Thomsen,Gudmar Thorleifsson,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,Ioanna Tzoulaki,André G. Uitterlinden,Simona Vaccargiu,Rob M. van Dam,Pim van der Harst,Cornelia M. van Duijn,Digna R. Velez Edward,Niek Verweij,Suzanne Vogelezang,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,Lars Wallentin,Ya Xing Wang,Chaolong Wang,Dawn M. Waterworth,Wen Bin Wei,Harvey D. White,John Whitfield,Sarah H. Wild,James F. Wilson,Mary K. Wojczynski,Charlene A. Wong,Tien Yin Wong,Liang Xu,Qiong Yang,Masayuki Yasuda,Laura M. Yerges-Armstrong,Weihua Zhang,Alan B. Zonderman,Jerome I. Rotter,Murielle Bochud,Bruce M. Psaty,Veronique Vitart,James G. Wilson,Abbas Dehghan,Afshin Parsa,Daniel I. Chasman,Kevin Ho,Andrew P. Morris,Olivier Devuyst,Shreeram Akilesh,Sarah A. Pendergrass,Xueling Sim,Carsten A. Böger,Yukinori Okada,Todd L. Edwards,Harold Snieder,Kari Stefansson,Adriana M. Hung,Iris M. Heid,Markus Scholz,Alexander Teumer,Anna Köttgen,Cristian Pattaro +327 more
TL;DR: Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.
Journal ArticleDOI
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Louise V. Wain,Louise V. Wain,Nick Shrine,María Soler Artigas,A. Mesut Erzurumluoglu,Boris Noyvert,Lara Bossini-Castillo,Ma'en Obeidat,Amanda P. Henry,Michael A. Portelli,Robert J. Hall,Charlotte K. Billington,Tracy L. Rimington,Anthony G. Fenech,Catherine John,Tineka Blake,Victoria E. Jackson,Richard J. Allen,Bram P. Prins,Archie Campbell,David J. Porteous,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Matthias Wielscher,Alan James,Alan James,Jennie Hui,Jennie Hui,Nicholas J. Wareham,Jing Hua Zhao,James F. Wilson,Peter K. Joshi,Beate Stubbe,Rajesh Rawal,Holger Schulz,Medea Imboden,Nicole Probst-Hensch,Stefan Karrasch,Christian Gieger,Ian J. Deary,Sarah E. Harris,Jonathan Marten,Igor Rudan,Stefan Enroth,Ulf Gyllensten,Shona M. Kerr,Ozren Polasek,Ozren Polasek,Mika Kähönen,Ida Surakka,Veronique Vitart,Caroline Hayward,Terho Lehtimäki,Olli T. Raitakari,David M. Evans,David M. Evans,A. John Henderson,Craig E. Pennell,Carol A. Wang,Peter D. Sly,Emily S. Wan,Robert Busch,Brian D. Hobbs,Augusto A. Litonjua,David Sparrow,Amund Gulsvik,Per Bakke,James D. Crapo,Terri H. Beaty,Nadia N. Hansel,Rasika A. Mathias,Ingo Ruczinski,Kathleen C. Barnes,Yohan Bossé,Philippe Joubert,Maarten van den Berge,Corry-Anke Brandsma,Peter D. Paré,Don D. Sin,David C. Nickle,Ke Hao,Omri Gottesman,Frederick E. Dewey,Shannon Bruse,David J. Carey,H. Lester Kirchner,Stefan Jonsson,Gudmar Thorleifsson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorarinn Gislason,Kari Stefansson,Kari Stefansson,Claudia Schurmann,Girish N. Nadkarni,Erwin P. Bottinger,Ruth J. F. Loos,Robin G. Walters,Zhengming Chen,Iona Y Millwood,Julien Vaucher,Om P Kurmi,Liming Li,Liming Li,Anna Hansell,Christopher E. Brightling,Christopher E. Brightling,Eleftheria Zeggini,Michael H. Cho,Edwin K. Silverman,Ian Sayers,Gosia Trynka,Andrew P. Morris,David P. Strachan,Ian P. Hall,Martin D. Tobin,Martin D. Tobin +116 more
TL;DR: In this article, a genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and they observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest GA risk score deciles in UK Biobank.
Journal ArticleDOI
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors
Ari Ahola-Olli,Peter Würtz,Aki S. Havulinna,Kristiina Aalto,Niina Pitkänen,Terho Lehtimäki,Mika Kähönen,Leo-Pekka Lyytikäinen,Emma Raitoharju,Ilkka Seppälä,Antti-Pekka Sarin,Samuli Ripatti,A. Palotie,Markus Perola,Jorma S. A. Viikari,Jorma S. A. Viikari,Sirpa Jalkanen,Mikael Maksimow,Veikko Salomaa,Marko Salmi,Johannes Kettunen,Olli T. Raitakari,Olli T. Raitakari,Olli T. Raitakari +23 more
TL;DR: In this paper, the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases were clarified using a genome-wide association study (GWAS) of up to 8,293 Finns.