T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Novel genes for autism implicate both excitatory and inhibitory cell lineages in risk
F. Kyle Satterstrom,F. Kyle Satterstrom,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,Silvia De Rubeis,Joon Yong An,Minshi Peng,Ryan Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Christine Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Richard Anney,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Angel Carracedo,Marcus C.Y. Chan,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Bernardo Dalla Bernardina,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montserrat Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,J. Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Emily Hansen-Kiss,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,W. Ian Lipkin,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Eduarda Montenegro M. de Souza,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Benjamin M. Neale,Merete Nordentoft,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Isabela Maya Wahys Silva,Tarjinder Singh,Tarjinder Singh,Paige M. Siper,Moyra Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Maria del Pilar Trelles,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,A. Jeremy Willsey,Timothy W. Yu,Mullin H.C. Yu,Ryan Yuen,Elaine Cristina Zachi,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,Thomas Lehner,Geetha Senthil,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,A. Ercument Cicek,A. Ercument Cicek,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Joseph D. Buxbaum,Mark J. Daly +172 more
TL;DR: The largest exome sequencing study to date focused on rare variation in autism spectrum disorder (ASD) is presented, and 99 genes in ASD risk are implicate at a false discovery rate of 0.1, implying that disruption of these genes alters the development of both neuron types.
Journal ArticleDOI
Influence of Child and Adult Elevated Blood Pressure on Adult Arterial Stiffness : The Cardiovascular Risk in Young Finns Study
Heikki Aatola,Teemu Koivistoinen,Heikki Tuominen,Markus Juonala,Terho Lehtimäki,Jorma Viikari,Olli T. Raitakari,Mika Kähönen,Nina Hutri-Kähönen +8 more
TL;DR: The results were consistent when different definitions for child and adult elevated BP were applied, and highlight the importance of BP control in the primary prevention of cardiovascular diseases.
Journal ArticleDOI
Blood leukocyte count is a risk factor for intima-media thickening and subclinical carotid atherosclerosis in middle-aged men.
Antti Loimaala,Riikka Rontu,Ilkka Vuori,Michele Mercuri,Terho Lehtimäki,Arja Nenonen,M. Gene Bond +6 more
TL;DR: Leukocytes seem to have an independent role in the early arterial damage and they may reflect subclinical disease, implying that leukocyte count is undervalued in the diagnostics and prognostics of carotid atherosclerosis.
Journal ArticleDOI
Major human plasma lipid classes determined by quantitative high-performance liquid chromatography, their variation and associations with phospholipid fatty acids.
Tuulikki Seppänen-Laakso,Into Laakso,Hannu Vanhanen,K. Kiviranta,Terho Lehtimäki,Raimo Hiltunen +5 more
TL;DR: In comparison to other lipid classes, quantitation of PC proved to be equally repeatable despite its lowest detector response, and the relative recoveries varied from 97.0 to 110.3%, showing good accuracy of the method.
Journal ArticleDOI
Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.
Henna Martiskainen,Seppo Helisalmi,Jayashree Viswanathan,Mitja I. Kurki,Anette Hall,Sanna-Kaisa Herukka,Timo Sarajärvi,Teemu Natunen,Kaisa M.A. Kurkinen,Jaakko Huovinen,Petra Mäkinen,Marjo Laitinen,Anne M. Koivisto,Kari M. Mattila,Terho Lehtimäki,Anne M. Remes,Ville Leinonen,Annakaisa Haapasalo,Hilkka Soininen,Mikko Hiltunen +19 more
TL;DR: AD risk loci polygenically contribute to Aβ pathology in the CSF and temporal cortex, and this effect is potentially associated with increased γ-secretase activity.