T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Richard Karlsson Linnér,Pietro Biroli,Edward Kong,Fleur Meddens,Robbee Wedow,Mark Alan Fontana,Mael Lebreton,Stephen P. Tino,Abdel Abdellaoui,Anke R. Hammerschlag,Michel G. Nivard,Aysu Okbay,Cornelius A. Rietveld,Pascal N. Timshel,Maciej Trzaskowski,Ronald de Vlaming,Christian L. Zund,Yanchun Bao,Laura Buzdugan,Ann H. Caplin,Chia-Yen Chen,Peter Eibich,Pierre Fontanillas,Juan R. González,Peter K. Joshi,Ville Karhunen,Aaron Kleinman,Remy Z. Levin,Christina M. Lill,Gerardus A. Meddens,Gerard Muntané,Sandra Sanchez-Roige,Frank J. A. van Rooij,Erdogan Taskesen,Yang Wu,Futao Zhang,Michelle Agee,Babak Alipanahi,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Nicholas A. Furlotte,Karen E. Huber,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Joanna L. Mountain,Carrie A.M. Northover,Steven J. Pitts,J. Fah Sathirapongsasuti,Olga V. Sazonova,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Catherine H. Wilson,Mawusse Agbessi,Habibul Ahsan,Isabel Alves,Anand Kumar Andiappan,Philip Awadalla,Alexis Battle,Frank Beutner,Marc Jan Bonder,Dorret I. Boomsma,Mark W. Christiansen,Annique Claringbould,Patrick Deelen,Tõnu Esko,Marie-Julie Favé,Lude Franke,Timothy M. Frayling,Sina A. Gharib,Gregory Gibson,Bastiaan T. Heijmans,Gibran Hemani,Rick Jansen,Mika Kähönen,Anette Kalnapenkis,Silva Kasela,Johannes Kettunen,Yungil Kim,Holger Kirsten,Peter Kovacs,Knut Krohn,Jaanika Kronberg-Guzman,Viktorija Kukushkina,Zoltán Kutalik,Bernett Lee,Terho Lehtimäki,Markus Loeffler,Urko M. Marigorta,Andres Metspalu,Lili Milani,Grant W. Montgomery,Martina Mueller-Nurasyid,Matthias Nauck,Brenda W.J.H. Penninx,Markus Perola,Natalia Pervjakova,Brandon L. Pierce,Joseph E. Powell,Holger Prokisch,Bruce M. Psaty,Olli T. Raitakari,Susan M. Ring,Samuli Ripatti,Olaf Rotzchke,Sina Rüeger,Ashis Saha,Markus Scholz,Katharina Schramm,Ilkka Seppälä,Michael Stumvoll,Patrick Sullivan,Peter-Bramt Hoen,Alexander Teumer,Joachim Thiery,Lin Tong,Anke Tönjes,Jenny van Dongen,Joyce B. J. van Meurs,Joost Verlouw,Peter M. Visscher,Uwe Voelker,Urmo Võsa,Harm-Jan Westra,Hanieh Yaghootkar,Jian Yang,Biao Zeng,James J. Lee,Tune H. Pers,Patrick Turley,Guo-Bo Chen,Valur Emilsson,Sven Oskarsson,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Augustine Kong,Jari Lahti,Sven J. van der Lee,Christiaan de Leeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Wouter J. Peyrot,Yong Qian,Rico Rueedi,Erika Salvi,Boerge Schmidt,Katharina E. Schraut,Jianxin Shi,Albert V. Smith,Raymond A. Poot,Beate St Pourcain,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Ilja Demuth,Jun Ding,Lewin Eisele,Niina Eklund,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Gunnarsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Pedro Marques-Vidal,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Ronny Myhre,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,David J. Porteous,Katri Räikkönen,S M Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Antti-Pekka Sarin,Helena Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Cristina Venturini,Anna A. E. Vinkhuyzen,Henry Voelzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Erin B. Ware,Gonneke Willemsen,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Hans Bisgaard,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Paolo Gasparini,Pablo V. Gejman,Christian Gieger,Hans-Joergen Grabe,Jacob Gratten,Vilmundur Gudnason,Pim van der Harst,Caroline Hayward,David A. Hinds,Wolfgang Hoffmann,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Steven F. Lehrer,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Neil Pendleton,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,David Schlessinger,Reinhold E. Schmidt,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,Dalton Conley,Robert F. Krueger,George Davey Smith,David Laibson,Sarah E. Medland,Magnus Johannesson,Philipp Koellinger,David Cesarini,Daniel J. Benjamin,Adam Auton,Jason D. Boardman,David W. Clark,Andrew Conlin,Conor C. Dolan,Urs Fischbacher,Patrick J. F. Groenen,Kathleen Mullan Harris,Gregor Hasler,Albert Hofman,Mohammad Arfan Ikram,Sonia Jain,Robert Karlsson,Ronald C. Kessler,Maarten Kooyman,James MacKillop,Minna Männikkö,Carlos Morcillo-Suarez,Matthew B. McQueen,Klaus M. Schmidt,Melissa C. Smart,Matthias Sutter,Jon White,Harriet de Wit,Ernst Fehr,Meena Kumari,David Laibson,Michelle N. Meyer,Arcadi Navarro,Abraham A. Palmer,Daniel Schunk,Murray B. Stein,Rauli Svento,Paul R. H. J. Timmers,Robert J. Ursano,Gert G. Wagner,Jonathan P. Beauchamp +387 more
TL;DR: A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.
Journal ArticleDOI
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity.
Maarit Hakanen,Olli T. Raitakari,Terho Lehtimäki,Nina Peltonen,Katja Pahkala,Lauri Sillanmäki,Hanna Lagström,Jorma Viikari,Olli Simell,Tapani Rönnemaa +9 more
TL;DR: The results suggest that the effect of the FTO genotype on BMI becomes evident only after age 7 yr, and suggest thatThe FTO gene is not directly associated with energy intake or physical activity.
Journal ArticleDOI
Conventional Cardiovascular Risk Factors and Metabolic Syndrome in Predicting Carotid Intima-Media Thickness Progression in Young Adults The Cardiovascular Risk in Young Finns Study
Juha Koskinen,Mika Kähönen,Jorma Viikari,Leena Taittonen,Tomi Laitinen,Tapani Rönnemaa,Terho Lehtimäki,Nina Hutri-Kähönen,M. Pietikäinen,Eero Jokinen,Hans Helenius,Noora Mattsson,Olli T. Raitakari,Markus Juonala +13 more
TL;DR: Obesity, high low-density lipoprotein cholesterol, and high insulin level predicted IMT progression in young adults, and there was no evidence that MetS would predictIMT progression more than expected from the sum of its risk components.
Journal ArticleDOI
The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection
Scott C. Ritchie,Peter Würtz,Artika P. Nath,Gad Abraham,Aki S. Havulinna,Aki S. Havulinna,Liam G. Fearnley,Antti-Pekka Sarin,Antti J. Kangas,Pasi Soininen,Pasi Soininen,Kristiina Aalto,Ilkka Seppälä,Emma Raitoharju,Marko Salmi,Marko Salmi,Mikael Maksimow,Mikael Maksimow,Satu Männistö,Mika Kähönen,Markus Juonala,Samuli Ripatti,Terho Lehtimäki,Sirpa Jalkanen,Markus Perola,Markus Perola,Olli T. Raitakari,Olli T. Raitakari,Veikko Salomaa,Mika Ala-Korpela,Johannes Kettunen,Johannes Kettunen,Johannes Kettunen,Michael Inouye +33 more
TL;DR: It is demonstrated that GlycA is a biomarker for chronic inflammation, neutrophil activity, and risk of future severe infection, and the utility of leveraging multi-layered omics data and health records to elucidate the molecular and cellular processes associated with biomarkers.
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Yingchang Lu,Felix R. Day,Stefan Gustafsson,Stefan Gustafsson,Martin L. Buchkovich,Jianbo Na,Veronique Bataille,Veronique Bataille,Diana L. Cousminer,Zari Dastani,Alexander W. Drong,Tõnu Esko,David M. Evans,Mario Falchi,Mario Falchi,Mary F. Feitosa,Teresa Ferreira,Åsa K. Hedman,Robin Haring,Robin Haring,Pirro G. Hysi,Mark M. Iles,Anne E. Justice,Stavroula Kanoni,Stavroula Kanoni,Vasiliki Lagou,Rui Li,Xin Li,Adam E. Locke,Chen Lu,Reedik Mägi,John R. B. Perry,Tune H. Pers,Qibin Qi,Marianna Sanna,Marianna Sanna,Ellen M. Schmidt,William R. Scott,William R. Scott,Dmitry Shungin,Dmitry Shungin,Alexander Teumer,Anna A. E. Vinkhuyzen,Ryan W. Walker,Harm-Jan Westra,Mingfeng Zhang,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Zhihong Zhu,Uzma Afzal,Uzma Afzal,Tarunveer S. Ahluwalia,Stephan J. L. Bakker,Claire Bellis,Amélie Bonnefond,Amélie Bonnefond,Katja Borodulin,Aron S. Buchman,Tommy Cederholm,Audrey C. Choh,Hyung Jin Choi,Joanne E. Curran,Lisette C. P. G. M. de Groot,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Rosalie A. M. Dhonukshe-Rutten,Anke W. Enneman,Elodie Eury,Elodie Eury,Daniel S. Evans,Tom Forsén,Nele Friedrich,Frédéric Fumeron,Melissa E. Garcia,Simone Gärtner,Bok-Ghee Han,Aki S. Havulinna,Caroline Hayward,Dena G. Hernandez,Hans L. Hillege,Till Ittermann,Jack W. Kent,Ivana Kolcic,Tiina Laatikainen,Tiina Laatikainen,Jari Lahti,Irene Mateo Leach,Christine G. Lee,Christine G. Lee,Jong-Young Lee,Tian Liu,Youfang Liu,Stéphane Lobbens,Stéphane Lobbens,Marie Loh,Marie Loh,Leo-Pekka Lyytikäinen,Carolina Medina-Gomez,Karl Michaëlsson,Mike A. Nalls,Carrie M. Nielson,Laticia Oozageer,Laura Pascoe,Lavinia Paternoster,Ozren Polasek,Ozren Polasek,Samuli Ripatti,Samuli Ripatti,Mark A. Sarzynski,Chan Soo Shin,Nina Smolej Narančić,Dominik Spira,Priya Srikanth,Elisabeth Steinhagen-Thiessen,Yun Ju Sung,Karin M. A. Swart,Karin M. A. Swart,Leena Taittonen,Toshiko Tanaka,Emmi Tikkanen,Nathalie van der Velde,Natasja M. van Schoor,Natasja M. van Schoor,Niek Verweij,Alan F. Wright,Lei Yu,Joseph M. Zmuda,Niina Eklund,Terrence Forrester,Niels Grarup,Anne U. Jackson,Kati Kristiansson,Kati Kristiansson,Teemu Kuulasmaa,Johanna Kuusisto,Peter Lichtner,Jian'an Luan,Anubha Mahajan,Satu Männistö,Cameron D. Palmer,Cameron D. Palmer,Janina S. Ried,Robert A. Scott,Alena Stančáková,Peter Wagner,Peter Wagner,Ayse Demirkan,Angela Döring,Vilmundur Gudnason,Douglas P. Kiel,Brigitte Kühnel,Massimo Mangino,Barbara McKnight,Barbara McKnight,Cristina Menni,Jeffrey R. O'Connell,Ben A. Oostra,Alan R. Shuldiner,Alan R. Shuldiner,Kijoung Song,Liesbeth Vandenput,Cornelia M. van Duijn,Peter Vollenweider,Charles C. White,Michael Boehnke,Yvonne Boettcher,Richard S. Cooper,Nita G. Forouhi,Christian Gieger,Harald Grallert,Aroon D. Hingorani,Torben Jørgensen,Torben Jørgensen,Pekka Jousilahti,Mika Kivimäki,Meena Kumari,Markku Laakso,Claudia Langenberg,Allan Linneberg,Amy Luke,Colin A. McKenzie,Aarno Palotie,Aarno Palotie,Aarno Palotie,Oluf Pedersen,Annette Peters,Konstantin Strauch,Bamidele O. Tayo,Nicholas J. Wareham,David A. Bennett,Lars Bertram,Lars Bertram,John Blangero,Matthias Blüher,Claude Bouchard,Harry Campbell,Nam H. Cho,Steven R. Cummings,Stefan A. Czerwinski,Ilja Demuth,Rahel Eckardt,Johan G. Eriksson,Johan G. Eriksson,Luigi Ferrucci,Oscar H. Franco,Philippe Froguel,Philippe Froguel,Ron T. Gansevoort,Torben Hansen,Torben Hansen,Tamara B. Harris,Nicholas D. Hastie,Markku Heliövaara,Albert Hofman,Joanne M. Jordan,Antti Jula,Mika Kähönen,Eero Kajantie,Eero Kajantie,Eero Kajantie,Paul Knekt,Seppo Koskinen,Peter Kovacs,Terho Lehtimäki,Lars Lind,Yongmei Liu,Eric S. Orwoll,Clive Osmond,Markus Perola,Markus Perola,Louis Pérusse,Olli T. Raitakari,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Treva Rice,Fernando Rivadeneira,Igor Rudan,Veikko Salomaa,Thorkild I. A. Sørensen,Michael Stumvoll,Anke Tönjes,Bradford Towne,Gregory J. Tranah,Angelo Tremblay,André G. Uitterlinden,Pim van der Harst,Erkki Vartiainen,Jorma S. A. Viikari,Veronique Vitart,Marie-Claude Vohl,Henry Völzke,Mark Walker,Mark Walker,Henri Wallaschofski,Sarah H Wild,James F. Wilson,Loic Yengo,Loic Yengo,D. Timothy Bishop,Ingrid B. Borecki,Ingrid B. Borecki,John C. Chambers,John C. Chambers,John C. Chambers,L. Adrienne Cupples,Abbas Dehghan,Panos Deloukas,Panos Deloukas,Panos Deloukas,Ghazaleh Fatemifar,Caroline S. Fox,Terrence S. Furey,Lude Franke,Jiali Han,David J. Hunter,Juha Karjalainen,Fredrik Karpe,Robert C. Kaplan,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Mark I. McCarthy,Joanne M. Murabito,Andrew P. Morris,Andrew P. Morris,Julia A. Newton Bishop,Kari E. North,Claes Ohlsson,Ken K. Ong,Inga Prokopenko,J. Brent Richards,Eric E. Schadt,Tim D. Spector,Elisabeth Widen,Cristen J. Willer,Jian Yang,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Karen L. Mohlke,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,John Andrew Pospisilik,M. Carola Zillikens,Cecilia M. Lindgren,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Ruth J. F. Loos +311 more
TL;DR: In this paper, the authors conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals to increase the understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk.