T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Journal ArticleDOI
Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis
Pradeep Natarajan,Joshua C. Bis,Lawrence F. Bielak,Amanda J. Cox,Marcus Dörr,Mary F. Feitosa,Nora Franceschini,Xiuqing Guo,Shih-Jen Hwang,Aaron Isaacs,Min A. Jhun,Maryam Kavousi,Ruifang Li-Gao,Leo-Pekka Lyytikäinen,Riccardo E. Marioni,Riccardo E. Marioni,Ulf Schminke,Nathan O. Stitziel,Hayato Tada,Jessica van Setten,Albert V. Smith,Dina Vojinovic,Lisa R. Yanek,Jie Yao,Laura M. Yerges-Armstrong,Najaf Amin,Usman Baber,Ingrid B. Borecki,J. Jeffrey Carr,Yii-Der Ida Chen,L. Adrienne Cupples,L. Adrienne Cupples,Pim A. de Jong,Harry J. de Koning,Bob D. de Vos,Ayse Demirkan,Valentin Fuster,Oscar H. Franco,Mark O. Goodarzi,Tamara B. Harris,Susan R. Heckbert,Gerardo Heiss,Udo Hoffmann,Albert Hofman,Albert Hofman,Ivana Išgum,J. Wouter Jukema,Mika Kähönen,Sharon L.R. Kardia,Brian G. Kral,Lenore J. Launer,Joseph M. Massaro,Roxana Mehran,Braxton D. Mitchell,Braxton D. Mitchell,Thomas H. Mosley,Renée de Mutsert,Anne B. Newman,Khanh-Dung H. Nguyen,Kari E. North,Jeffrey R. O'Connell,Matthijs Oudkerk,James S. Pankow,Gina M. Peloso,Gina M. Peloso,Wendy Post,Michael A. Province,Laura M. Raffield,Olli T. Raitakari,Dermot F. Reilly,Fernando Rivadeneira,Frits R. Rosendaal,Samantha Sartori,Kent D. Taylor,Alexander Teumer,Stella Trompet,Stephen Turner,André G. Uitterlinden,Dhananjay Vaidya,Aad van der Lugt,Uwe Völker,Joanna M. Wardlaw,Christina L. Wassel,Stefan Weiss,Mary K. Wojczynski,Diane M. Becker,Lewis C. Becker,Eric Boerwinkle,Eric Boerwinkle,Donald W. Bowden,Ian J. Deary,Abbas Dehghan,Abbas Dehghan,Stephan B. Felix,Vilmundur Gudnason,Terho Lehtimäki,Rasika A. Mathias,Dennis O. Mook-Kanamori,Bruce M. Psaty,Daniel J. Rader,Jerome I. Rotter,James G. Wilson,Cornelia M. van Duijn,Henry Völzke,Sekar Kathiresan,Patricia A. Peyser,Christopher J. O'Donnell +106 more
TL;DR: APOE &egr;2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities, as well as clinical coronary heart disease, and exome-wide association meta-analysis demonstrates that protein-coding variants in APOB and APOE associate with subclinical Atherosclerosis.
Journal ArticleDOI
Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study.
Niku Oksala,Mari Levula,Markku Pelto-Huikko,Leena Kytömäki,Juhani T. Soini,Juha Salenius,Mika Kähönen,Pekka J. Karhunen,Reijo Laaksonen,Seppo Parkkila,Terho Lehtimäki +10 more
TL;DR: Evidence is provided for the involvement of CAs in advanced atherosclerosis in osteoclast-like cells of monocyte-macrophage lineage in atherosclerotic plaques using immunohistochemistry and double-staining immunofluorescence analysis.
Journal ArticleDOI
Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects
Jenni Koskela,Anna Tahvanainen,Antti Haring,Antti Tikkakoski,Erkki Ilveskoski,Jani Viitala,Miia H. Leskinen,Terho Lehtimäki,Mika Kähönen,Tiit Kööbi,Onni Niemelä,Jukka Mustonen,Ilkka Pörsti +12 more
TL;DR: Supine and upright hemodynamic profile associated with higher resting HR is characterized by higher cardiac output and lower systemic vascular resistance, in spite of elevated BP and arterial stiffness, which may explain why higher HR is associated with less favourable prognosis in populations.
Journal ArticleDOI
Predictive value of serum human epididymis protein 4 and cancer antigen 125 concentrations in endometrial carcinoma
Sami Kristian Saarelainen,Nina Peltonen,Terho Lehtimäki,Antti Perheentupa,Maarit Vuento,Johanna Mäenpää +5 more
TL;DR: A combination of preoperative HE4 and CA125 seems to be a better predictor of metastatic disease than either 1 alone in endometrial carcinoma.
Journal ArticleDOI
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analysis of 458 population-based studies in Asian and Western countries
Cristina Taddei,Rod Jackson,Bin Zhou,Honor Bixby,Goodarz Danaei,Mariachiara Di Cesare,Kari Kuulasmaa,Kaveh Hajifathalian,James Bentham,James E. Bennett,Wichai Aekplakorn,Renata Cifkova,Jean Dallongeville,Dirk DeBacquer,Simona Giampaoli,Vilmundur Gudnason,Young-Ho Khang,Tiina Laatikainen,Jimi Mann,Pedro Marques-Vidal,Georgea Mensah,Martina Müller-Nurasyid,Toshiharu Ninomiya,Janina Petkeviciene,Fernando Rodríguez-Artalejo,Jennifer Servais,Stefan Söderberg,Bill Stavreski,Tom Wilsgaard,Tomasz Zdrojewski,Dong Zhao,Gretchen A Stevens,Stefan Savin,Melanie J. Cowan,Leanne M. Riley,Majid Ezzati,Robert J. Adams,Wolfgang Ahrens,Philippe Amouyel,Antoinette Amuzu,Sigmund A. Anderssen,Inger Ariansen,Dominique Arveiler,Thor Aspelund,Juha Auvinen,Maria Avdicova,Maciej Banach,Piotr Bandosz,José R. Banegas,Carlo M. Barbagallo,Iqbal Bata,Louise A. Baur,Robert Beaglehole,Gailute Bernotiene,Yufang Bi,Asako Bienek,Cecilia Björkelund,Simona Bo,Bernhard O. Boehm,Marialaura Bonaccio,Vanina Bongard,Rossana Borchini,Herman Borghs,Juergen Breckenkamp,Hermann Brenner,Graziella Bruno,Markusa Busch,Antonio Cabreradeleón,Vincenzo Capuano,Felipe F. Casanueva,Juan P. Casas,Carmelo A. Caserta,Laura Censi,Fangfang Chen,Shuohua Chen,María Dolores Chirlaque,Belong Cho,Yumi Cho,Jerzy Chudek,Frank Claessens,Janine Clarke,Els Clays,Cyrus Cooper,Simona Costanzo,Dominique Cottel,Christopher T. Cowell,Ana B. Crujeiras,Liufu Cui,Graziella D'Arrigo,Luc Dauchet,Guy De Backer,Dirk De Bacquer,Giovanni de Gaetano,Stefaan De Henauw,Delphine De Smedt,Elaine M. Dennison,Valérie Deschamps,Augusto Dicastelnuovo,Annette J. Dobson,Chiara Donfrancesco,Angela Döring,Wojciech Drygas,Yong Du,Elżbieta Dziankowska-Zaborszczyk,Robert Eggertsen,Ulf Ekelund,Roberto Elosua,Johan G. Eriksson,Alun Evans,David Faeh,Francisco J. Félix-Redondo,Daniel Fernández-Bergés,Marika Ferrari,Jean Ferrières,Joseph D. Finn,Ann-Sofie Forslund,Maria Forsner,Guillermo Frontera,Yuki Fujita,Zbigniew Gaciong,Fabio Galvano,Jingli Gao,Manoli Garcia-de-la-Hera,Sarah P. Garnett,Jean-Michel Gaspoz,Magda Gasull,Louise Gates,Francesco Gianfagna,Tiffany K. Gill,Jonathan Giovannelli,David Goltzman,Marcela González-Gross,Frederic Gottrand,Sidsel Graff-Iversen,Dusan Grafnetter,Ronald D. Gregor,Tomasz Grodzicki,Giuseppe Grosso,Grabriella Gruden,Dongfeng Gu,Pilar Guallar-Castillón,Elias F. Gudmundsson,Idris Guessous,Johanna Gunnlaugsdottir,Felix Gutzwiller,Rebecca Hardy,Jun Hata,Teresa Haugsgjerd,Alison J. Hayes,Jiang He,Yuna He,Sauli Herrala,Ilpo Tapanihihtaniemi,Michael Hobbs,Wilma M. Hopman,José Maríahuerta,Inge Huybrechts,Licia Iacoviello,Anna G. Iannone,Nayu Ikeda,Masanori Iwasaki,Konrad Jamrozik,Imre Janszky,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Grazyna Jasienska,Garry L. Jennings,Seung Lyeal Jeong,Chao Qiangjiang,Michel Joffres,Jari Jokelainen,Jost B. Jonas,Jacek Jóźwiak,Eero Kajantie,Jussi Kauhanen,Ulrich Keil,Sirkka Keinänen-Kiukaanniemi,Mathilde Kersting,Ursula Kiechl-Kohlendorfer,Stefan Kiechl,Jeongseon Kim,Yeon Yong Kim,Jurate Klumbiene,Michael Knoflach,Stephanie Ko,Elin Kolle,Raija Korpelainen,Seppo Koskinen,Katsuyasu Kouda,Wolfgang Kratzer,Susi Kriemler,Steinar Krokstad,Urhom Kujala,Pawel Kurjata,Tai Hinglam,Vera Lanska,Georg Lappas,Lars E. Laugsand,Jeonghee Lee,Terho Lehtimäki,Yanping Li,Christa L. Lilly,Xu Lin,Lars Lind,Lauren Lissner,Jing Liu,Esther Lopez-Garcia,Roberto Lorbeer,José Eugeniolozano,Dalia Luksiene,Annamari Lundqvist,Robert Lundqvist,Per Lytsy,Guansheng Ma,Suka Machi,Stefania Maggi,Dianna J. Magliano,Jim Mann,Enzo Manzato,Ellisiv B. Mathiesen,Stela McLachlan,Rachael McLean,B. S. Scott,Aline Meirhaeghe,C. Christa,Patricia Metcalf,Jie Mi,Jody C Miller,Luis A. Moreno,Suzanne N Morin,Małgorzata Mossakowska,Maria Lorenza Muiesan,Jaakko Mursu,Harunobu Nakamura,Jana Námešná,M. Matthias,Eva Marianavarrete-Muñoz,William A. Neal,Ilona Nenko,Teemu J. Niiranen,Teemu J. Niiranen,Guang Ning,Marianna Noale,Sawada Norie,Davide Noto,Terence W O'Neill,Dermot O'Reilly,Kyungwon Oh,Orn Olafsson,Fred Michelpaccaud,Andrzej Pajak,Luigi Palmieri,Francesco Panza,Winsome R. Parnell,Markku Peltonen,Annette Peters,Astrid Petersmann,Iris Pigeot,Lorenza Pilotto,Aleksandra Piwońska,Pedro Plans-Rubio,Miquel Porta,Jacqueline F. Price,Jardena J. Puder,Soilee Puhakka,Ricardas Radisauskas,Olli T. Raitakari,Rafel Ramos,Josep Redon,Fernando Rigo,Maríadel Cristo Rodriguez-Perez,Dora Romaguera,Kimmo Ronkainen,Annika Rosengren,Joel G. R. Roy,Jean Bernard Ruidavets,Marcin Rutkowski,Benoit Salanave,Diego Salmerón,Veikko Salomaa,Jukka T. Salonen,Massimo Salvetti,Susana Sans,Jouko Saramies,Kai Uwe Saum,Christa Scheidt-Nave,Anja Schienkiewitz,Sabine Schipf,Carsteno Schmidt,Ben Schöttker,Sylvain Sebert,Abhijit Sen,Jonathan E. Shaw,Kenji Shibuya,Dong Wookshin,Rahman Shiri,Judith Simons,Leon A. Simons,Michael Sjöström,Jolanta Slowikowska-Hilczer,Przemyslaw Slusarczyk,Vincenzo Solfrizzi,Emily Sonestedt,Aicha Soumare,Jan A. Staessen,Maria G. Stathopoulou,Jostein Steene-Johannessen,Peter Stehle,Jutta Stieber,Doris Stöckl,Jakub Stokwiszewski,Johan Sundström,Paibul Suriyawongpaisal,Abdonas Tamosiunas,Eng Jootan,Anne W. Taylor,Grethe S. Tell,Lutgarde Thijs,Hanna Tolonen,Roman Topor-Madry,María Josétormo,Maties Torrent,Shoichiro Tsugane,Tomi-Pekka Tuomainen,Jaakko Tuomilehto,Christophe Tzourio,Hannu Uusitalo,Koen Vanherck,Dirk Vanderschueren,Diego Vanuzzo,Lars J. Vatten,Tomas Vega,Giovanni Veronesi,Jesús Vioque,Jyrki K. Virtanen,Sophie Visvikis-Siest,Peter Vollenweider,Sari Voutilainen,Martine Vrijheid,Aline Wagner,Anne Wagner,Ming-Dong Wang,Qian Wang,Ya Xingwang,S. Goya Wannamethee,Wenbin Wei,Andrzej Wiecek,Johann Willeit,Peter Willeit,Bogdan Wojtyniak,Andrew Wong,Mark Woodward,Aleksander Giwercmanwu,Frederick C. W. Wu,Shou Ling Wu,Haiquan Xu,Liang Xu,Weili Yan,Xiaoguang Yang,Xingwang Ye,Akihiro Yoshihara,Sabina Zambon,Wenhua Zhao +362 more
TL;DR: In this article, the authors compared trends in total, HDL and non-HDL cholesterol and the total to HDL cholesterol ratio in Asian and Western countries, with only a weak correlation with changes in total cholesterol (TC), HDL cholesterol (HDL) or non- HDL cholesterol.