T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Author response: Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
Paul R. H. J. Timmers,Ninon Mounier,Ninon Mounier,Kristi Läll,Krista Fischer,Zheng Ning,Xiao Feng,Andrew D. Bretherick,David W. Clark,Mawusse Agbessi,Habibul Ahsan,Isabel Alves,Anand Kumar Andiappan,Philip Awadalla,Alexis Battle,Marc Jan Bonder,D.I. Boomsma,Mark W. Christiansen,Annique Claringbould,Patrick Deelen,J. M. van Dongen,T Esko,Marie-Julie Favé,Lude Franke,Timothy M. Frayling,Sina A. Gharib,Greg Gibson,Gibran Hemani,Rick Jansen,Anette Kalnapenkis,Silva Kasela,Jarno Kettunen,Yungil Kim,Holger Kirsten,Peter Kovacs,Knut Krohn,Jaanika Kronberg-Guzman,Viktorija Kukushkina,Z. Kutalik,Mika Kähönen,Bernett Lee,Terho Lehtimäki,Markus Loeffler,Urko M. Marigorta,Andres Metspalu,J.B. van Meurs,Lili Milani,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Markus Perola,Natalia Pervjakova,Brandon L. Pierce,Joseph E. Powell,Holger Prokisch,Bruce M. Psaty,Olli T. Raitakari,Susan M. Ring,Samuli Ripatti,Olaf Rötzschke,Sina Rüeger,Ashis Saha,Markus Scholz,Katharina Schramm,Ilkka Seppälä,Michael Stumvoll,Patrick F. Sullivan,Alexander Teumer,Joachim Thiery,Lin Tong,Anke Tönjes,Joost Verlouw,Peter M. Visscher,Urmo Võsa,Uwe Völker,Hanieh Yaghootkar,Jian Yang,Biao Zeng,Futao Zhang,Xia Shen,Xia Shen,Xia Shen,Tõnu Esko,Tõnu Esko,Zoltán Kutalik,Zoltán Kutalik,James F. Wilson,Peter K. Joshi,Peter K. Joshi +89 more
Journal ArticleDOI
Extensive phenotype data and machine learning in prediction of mortality in acute coronary syndrome - the MADDEC study.
Jussi Hernesniemi,Shadi Mahdiani,Shadi Mahdiani,Juho Tynkkynen,Leo-Pekka Lyytikäinen,Pashupati P. Mishra,Terho Lehtimäki,Markku Eskola,Kjell Nikus,Kari Antila,Niku Oksala +10 more
TL;DR: The use of extensive phenotype data and novel machine learning improves prediction of mortality in ACS over traditional GRACE score and supervised machine learning methods such as logistic regression and extreme gradient boosting significantly outperform conventional risk assessment by the current golden standard GRace score.
Journal ArticleDOI
Breast feeding in infancy and arterial endothelial function later in life. The Cardiovascular Risk in Young Finns Study
Mikko J. Järvisalo,N. Hutri-Kähönen,Markus Juonala,Vera Mikkilä,Leena Räsänen,Terho Lehtimäki,Jorma Viikari,Olli T. Raitakari +7 more
TL;DR: Adult men who have been breast fed have better brachial endothelial function compared to men who has been formula fed, and breast feeding was not significantly associated with IMT or CAC in multivariable models.
Journal ArticleDOI
Matrix metalloproteinase 3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques
Perttu J. Pöllänen,Terho Lehtimäki,Jussi Mikkelsson,Erkki Ilveskoski,Tarja Kunnas,Markus Perola,Antti Penttilä,Kari M. Mattila,Seppo T. Nikkari,Kirsi Syrjäkoski,Pekka J. Karhunen +10 more
TL;DR: The joint action of two susceptibility loci, rather than single MMP genes alone, and the particular combination of MMP3 and MMP9 genotypes present at these loci may contribute to heterogeneity in the presentation of atherosclerosis.
Journal ArticleDOI
Genes involved in systemic and arterial bed dependent atherosclerosis--Tampere Vascular study.
Mari Levula,Niku Oksala,Nina Airla,Rainer Zeitlin,Juha-Pekka Salenius,Otso Järvinen,Maarit Venermo,Teemu Partio,Jukka Saarinen,Taija Somppi,Velipekka Suominen,Jyrki Virkkunen,Juha Hautalahti,Reijo Laaksonen,Mika Kähönen,Ari Mennander,Leena Kytömäki,Juhani T. Soini,Jyrki Parkkinen,Markku Pelto-Huikko,Terho Lehtimäki +20 more
TL;DR: This study describes comprehensively the gene expression changes that generally prevail in human atherosclerotic plaques, and site specific genes induced only in femoral or aortic plaques were found, reflecting that atherosclerosis process has unique features in different vascular beds.