T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Matthew Moll,Phuwanat Sakornsakolpat,Phuwanat Sakornsakolpat,Nick Shrine,Brian D. Hobbs,Dawn L. DeMeo,Catherine John,Anna L. Guyatt,Michael J. McGeachie,Sina A. Gharib,Ma'en Obeidat,Ma'en Obeidat,Lies Lahousse,Lies Lahousse,Sara R.A. Wijnant,Sara R.A. Wijnant,Sara R.A. Wijnant,Guy Brusselle,Guy Brusselle,Deborah A. Meyers,Eugene R. Bleecker,Xingnan Li,Ruth Tal-Singer,Ani Manichaikul,Stephen S. Rich,Sungho Won,Woo Jin Kim,Ah Ra Do,George R. Washko,R. Graham Barr,Bruce M. Psaty,Bruce M. Psaty,Traci M. Bartz,Nadia N. Hansel,Kathleen C. Barnes,John E. Hokanson,James D. Crapo,David A. Lynch,Per Bakke,Amund Gulsvik,Ian P. Hall,Louise V. Wain,Louise V. Wain,María Soler Artigas,Victoria E. Jackson,David P. Strachan,Jennie Hui,Alan L. James,Shona M. Kerr,Ozren Polasek,Veronique Vitart,Jonathan Marten,Igor Rudan,Mika Kähönen,Ida Surakka,Christian Gieger,Stefan Karrasch,Rajesh Rawal,Holger Schulz,Ian J. Deary,Sarah E. Harris,Stefan Enroth,Ulf Gyllensten,Medea Imboden,Nicole Probst-Hensch,Terho Lehtimäki,Olli T. Raitakari,Claudia Langenberg,Jian'an Luan,Nicholas J. Wareham,Jing Hua Zhao,Caroline Hayward,Alison D. Murray,David J. Porteous,Blair H. Smith,Marjo-Riitta Järvelin,Matthias Wielscher,Peter K. Joshi,Katherine A. Kentistou,Paul R. H. J. Timmers,James F. Wilson,James P. Cook,Lars Lind,Anubha Mahajan,Andrew P. Morris,Ralf Ewert,Georg Homuth,Beate Stubbe,Stefan Weiss,Eleftheria Zeggini,Scott T. Weiss,Edwin K. Silverman,Edwin K. Silverman,Frank Dudbridge,Martin D. Tobin,Martin D. Tobin,Michael H. Cho +96 more
TL;DR: A risk score comprised of genetic variants can identify a small subset of individuals at markedly increased risk for moderate-to-severe COPD, emphysema subtypes associated with cigarette smoking, and patterns of reduced lung growth.
Journal ArticleDOI
Promoter polymorphism of IL-10 and severity of multiple sclerosis
Mari Luomala,Terho Lehtimäki,Heini Huhtala,M. Ukkonen,Timo Koivula,Mikko Hurme,Irina Elovaara +6 more
TL;DR: The results suggest that differential production of IL‐10 might be a factor in the severity of MS.
Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants
Rainer Malik,Tobias Freilinger,Verneri Anttila,Jason A. Vander Heiden,Matthew Traylor,Boukje de Vries,Elizabeth G. Holliday,Gisela M. Terwindt,Jonathan Sturm,Joshua C. Bis,Jemma C. Hopewell,Michel D. Ferrari,Kristiina Rannikmäe,Maija Wessman,Mikko Kallela,Christian Kubisch,Myriam Fornage,James F. Meschia,Terho Lehtimäki,Cathie Sudlow,Robert Clarke,Daniel I. Chasman,Braxton D. Mitchell,Jane Maguire,Jaakko Kaprio,Martin Farrall,Olli T. Raitakari,Tobias Kurth,M. Arfan Ikram,Alexander P. Reiner,W. T. Longstreth,Peter M. Rothwell,David P. Strachan,Pankaj Sharma,Sudha Seshadri,Lydia Quaye,Lynn Cherkas,Markus Schuerks,Jonathan Rosand,Lannie Ligthart,Giorgio B. Boncoraglio,George Davey Smith,Cornelia M. van Duijn,Kari Stefansson,Bradford B. Worrall,Dale R. Nyholt,Hugh S. Markus,Arn M. J. M. van den Maagdenberg,Chris Cotsapas,J.A. Zwart,Aarno Palotie,Martin Dichgans +51 more
TL;DR: The findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms.
Journal ArticleDOI
High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms
Mitja I. Kurki,Emilia I. Gaal,Johannes Kettunen,Tuuli Lappalainen,Androniki Menelaou,Verneri Anttila,Femke N G van 't Hof,Mikael von und zu Fraunberg,Seppo Helisalmi,Mikko Hiltunen,Hanna Lehto,Aki Laakso,Riku Kivisaari,Timo Koivisto,Antti Ronkainen,Jaakko Rinne,Lambertus A. Kiemeney,Sita H. Vermeulen,Mari A. Kaunisto,Johan G. Eriksson,Arpo Aromaa,Markus Perola,Terho Lehtimäki,Olli T. Raitakari,Veikko Salomaa,Murat Gunel,Emmanouil T. Dermitzakis,Ynte M. Ruigrok,Gabriël J.E. Rinkel,Mika Niemelä,Juha Hernesniemi,Samuli Ripatti,Paul I.W. de Bakker,Aarno Palotie,Juha E. Jääskeläinen +34 more
TL;DR: The most promising loci (p<5E-6) were replicated in 858 Finnish sIA patients and 4,048 controls as mentioned in this paper, which may relate to, but not explain, the increased incidence of sIA-SAH in Finland.
Posted ContentDOI
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Padhraig Gormley,Verneri Anttila,Bendik S. Winsvold,Priit Palta,Tõnu Esko,Tune H. Pers,Kai-How Farh,Ester Cuenca-León,Mikko Muona,Nicholas A. Furlotte,Tobias Kurth,Andres Ingason,George McMahon,Lannie Ligthart,Gisela M. Terwindt,Mikko Kallela,Tobias Freilinger,Caroline Ran,Scott G. Gordon,Anine H. Stam,Stacy Steinberg,Guntram Borck,Markku Koiranen,Lydia Quaye,Hieab H.H. Adams,Terho Lehtimäki,Antti-Pekka Sarin,Juho Wedenoja,David A. Hinds,Julie E. Buring,Markus Schürks,Paul M. Ridker,Maria Gudlaug Hrafnsdottir,Hreinn Stefansson,Susan M. Ring,Jouke-Jan Hottenga,Brenda W.J.H. Penninx,Markus Färkkilä,Ville Artto,Mari A. Kaunisto,Salli Vepsäläinen,Rainer Malik,Andrew C. Heath,Pamela A. F. Madden,Nicholas G. Martin,Grant W. Montgomery,Eija Hamalainen,Hailiang Huang,Andrea Byrnes,Lude Franke,Jie Huang,Evie Stergiakouli,Phil Lee,Cynthia Sandor,Caleb Webber,Zameel M. Cader,Bertram Müller-Myhsok,Stefan Schreiber,Thomas Meitinger,Johan G. Eriksson,Veikko Salomaa,Kauko Heikkilä,Elizabeth Loehrer,André G. Uitterlinden,Albert Hofman,Cornelia M. van Duijn,Lynn Cherkas,Linda M. Pedersen,Audun Stubhaug,Christopher Sivert Nielsen,Minna Männikkö,Evelin Mihailov,Lili Milani,Hartmut Göbel,Ann-Louise Esserlind,Anne Francke Christensen,Thomas Hansen,Thomas Werge,Jaakko Kaprio,Arpo Aromaa,Olli T. Raitakari,M. Arfan Ikram,Tim D. Spector,Marjo-Riitta Järvelin,Andres Metspalu,Christian Kubisch,David P. Strachan,Michel D. Ferrari,Andrea Carmine Belin,Martin Dichgans,Maija Wessman,Arn M. J. M. van den Maagdenberg,John-Anker Zwart,Dorret I. Boomsma,George Davey Smith,Kari Stefansson,Nicholas Eriksson,Mark J. Daly,Benjamin M. Neale,Jes Olesen,Daniel I. Chasman,Dale R. Nyholt,Aarno Palotie +102 more
TL;DR: The largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies, identified 45 independent single nucleotide polymorphisms significantly associated with migraine risk that map to 38 distinct genomic loci, including 28 loci not previously reported and the first locus identified on chromosome X.