T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Ophthalmic timolol: Plasma concentration and systemic cardiopulmonary effects
TL;DR: Since there is a correlation between the plasma level of timolol and several haemodynamic effects – especially HR in the state of elevated β‐adrenergic tonus – the CYP2D6 poor metabolizers may be more prone to bradycardia during treatment with (aqueous) ophthalmic Timolol.
Journal ArticleDOI
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
John D. Eicher,Nathalie Chami,Tim Kacprowski,Akihiro Nomura,Akihiro Nomura,Akihiro Nomura,Ming-Huei Chen,Lisa R. Yanek,Salman M. Tajuddin,Ursula M. Schick,Andrew J. Slater,Nathan Pankratz,Linda M. Polfus,Claudia Schurmann,Ayush Giri,Jennifer A. Brody,Leslie A. Lange,Ani Manichaikul,W. David Hill,Raha Pazoki,Paul Elliot,Evangelos Evangelou,Evangelos Evangelou,Ioanna Tzoulaki,Ioanna Tzoulaki,He Gao,Anne-Claire Vergnaud,Rasika A. Mathias,Diane M. Becker,Lewis C. Becker,Amber A. Burt,David R. Crosslin,Leo-Pekka Lyytikäinen,Kjell Nikus,Jussi Hernesniemi,Mika Kähönen,Emma Raitoharju,Nina Mononen,Olli T. Raitakari,Terho Lehtimäki,Mary Cushman,Neil A. Zakai,Deborah A. Nickerson,Laura M. Raffield,Rakale C. Quarells,Cristen J. Willer,Gina M. Peloso,Gina M. Peloso,Gina M. Peloso,Gonçalo R. Abecasis,Dajiang J. Liu,Panos Deloukas,Panos Deloukas,Nilesh J. Samani,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Myriam Fornage,Melissa A. Richard,Jean-Claude Tardif,John D. Rioux,Marie-Pierre Dubé,Simon de Denus,Yingchang Lu,Erwin P. Bottinger,Ruth J. F. Loos,Albert V. Smith,Tamara B. Harris,Lenore J. Launer,Vilmundur Gudnason,Digna R. Velez Edwards,Eric S. Torstenson,Yongmei Liu,Russell P. Tracy,Jerome I. Rotter,Stephen S. Rich,Heather M. Highland,Heather M. Highland,Eric Boerwinkle,Eric Boerwinkle,Jin Li,Ethan M. Lange,James G. Wilson,Evelin Mihailov,Reedik Mägi,Joel N. Hirschhorn,Joel N. Hirschhorn,Andres Metspalu,Tõnu Esko,Tõnu Esko,Caterina Vacchi-Suzzi,Mike A. Nalls,Alan B. Zonderman,Michele K. Evans,Gunnar Engström,Marju Orho-Melander,Olle Melander,Michelle L. O'Donoghue,Dawn M. Waterworth,Lars Wallentin,Harvey D. White,James S. Floyd,Traci M. Bartz,Kenneth Rice,Bruce M. Psaty,Bruce M. Psaty,John M. Starr,David C. Liewald,Caroline Hayward,Ian J. Deary,Andreas Greinacher,Uwe Völker,Thomas Thiele,Henry Völzke,Frank J. A. van Rooij,André G. Uitterlinden,Oscar H. Franco,Abbas Dehghan,Todd L. Edwards,Santhi K. Ganesh,Sekar Kathiresan,Sekar Kathiresan,Nauder Faraday,Paul L. Auer,Alexander P. Reiner,Alexander P. Reiner,Guillaume Lettre,Andrew D. Johnson +127 more
TL;DR: The authors' large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.
Journal ArticleDOI
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene Is a Risk Factor of Large-Vessel Atherosclerosis Stroke
Sherine Abboud,Sherine Abboud,Pekka J. Karhunen,Dieter Lütjohann,Sirkka Goebeler,Teemu M. Luoto,Silvia Friedrichs,Terho Lehtimäki,Massimo Pandolfo,Reijo Laaksonen,Reijo Laaksonen +10 more
TL;DR: Findings in this unique combination of clinical and autopsy data provide evidence that PCSK9 gene associates with the risk of LVA stroke subtype, and suggest that the risk is mediated by the severity of intracranial atherosclerosis.
Journal ArticleDOI
Association of an interleukin 1B gene polymorphism (−511) with Parkinson's disease in Finnish patients
TL;DR: Investigating whether polymorphisms of the IL1 cluster genes are associated with the risk of AD or PD in Finnish patients found some evidence in support of this.
Journal ArticleDOI
Adhesion molecules in multiple sclerosis: relation to subtypes of disease and methylprednisolone therapy.
Irina Elovaara,M. Ukkonen,Minna Leppäkynnäs,Terho Lehtimäki,Mari Luomala,Jukka Peltola,Prasun Dastidar +6 more
TL;DR: Up-regulated adhesion molecules in blood and CSF indicate sustained potential for inflammation in the CNS throughout the clinical spectrum of MS.