T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Journal ArticleDOI
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
Aysu Okbay,Yeda Wu,Nancy Wang,Hariharan Jayashankar,Michael Bennett,Seyed Moeen Nehzati,Julia Sidorenko,Hyeokmoon Kweon,Grant Goldman,Tamara Gjorgjieva,Yunxuan Jiang,B. Hicks,Chao Tian,David A. Hinds,Rafael Ahlskog,Patrik K. E. Magnusson,Sven Oskarsson,Caroline Hayward,Archie Campbell,David J. Porteous,Jeremy Freese,Pamela Herd,Michelle Agee,Babak Alipanahi,Adam Auton,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Pierre Fontanillas,Nicholas A. Furlotte,Karen E. Huber,Aaron Kleinman,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Joanna L. Mountain,Carrie A.M. Northover,Steven J. Pitts,J. Fah Sathirapongsasuti,Olga V. Sazonova,Janie F. Shelton,Suyash Shringarpure,Joyce Y. Tung,Vladimir Vacic,Catherine H. Wilson,Mark Alan Fontana,Tune H. Pers,Cornelius A. Rietveld,Guo-Bo Chen,Valur Emilsson,S. Fleur W. Meddens,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Ronald de Vlaming,Abdel Abdellaoui,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Robert Karlsson,Jari Lahti,S. J. van der Lee,Christiaan de Leeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Natalia Pervjakova,Wouter J. Peyrot,Yong-chao Qian,Olli T. Raitakari,Rico Rueedi,Erika Salvi,Börge Schmidt,Katharina E. Schraut,Jianxin Shi,Raymond A. Poot,Beate St Pourcain,Alexander Teumer,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Harm-Jan Westra,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Ilja Demuth,Jun Ding,Peter Eibich,Lewin Eisele,Niina Eklund,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Kristinn Gunnarsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew C. Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Mika Kähönen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Zoltán Kutalik,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichter,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Pedro Marques-Vidal,Gerardus A. Meddens,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Lili Milani,Grant W. Montgomery,Ronny Myhre,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,Katri Räikkönen,Susan M. Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Antti-Pekka Sarin,E. E. Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Frank J. A. van Rooij,Cristina Venturini,Anna A. E. Vinkhuyzen,Uwe Völker,Henry Völzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Erin B. Ware,Gonneke Willemsen,J. Attia,David A. Bennett,Klaus Berger,Lars Bertram,Hans Bisgaard,Dorret I. Boomsma,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,Ian J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Lude Franke,Paolo Gasparini,Pablo V. Gejman,Christian Gieger,Hans J. Grabe,Jacob Gratten,Patrick J. F. Groenen,Vilmundur Gudnason,P. Van der Harst,Wolfgang Hoffmann,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Terho Lehtimäki,Steven F. Lehrer,Nicholas G. Martin,Matt McGue,Andres Metspalu,Neil Pendleton,Brenda W.J.H. Penninx,Markus Perola,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,David Schlessinger,Reinhold Schmidt,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,R. Kroeger,George Davey Smith,Albert Hofman,David Laibson,Sarah E. Medland,Jian Yang,Tõnu Esko,Chelsea Coleman Watson,Jonathan B. Jala,Dalton Conley,Philipp Koellinger,Magnus Johannesson,Michelle N. Meyer,James J. Lee,Augustine Kong,Loic Yengo,David Cesarini,Patrick Turley,Peter M. Visscher,Jonathan P. Beauchamp,Daniel J. Benjamin,Alexander I. Young +294 more
TL;DR: This paper conducted a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identified 3,952 approximately uncorrelated single-nucleotide polymorphisms (SNPs).
Journal ArticleDOI
Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women
Saara Lehtinen,Terho Lehtimäki,Tero Sisto,Juha-Pekka Salenius,Matti Nikkilä,Hannu Jokela,Timo Koivula,Freja Ebeling,Christian Ehnholm +8 more
TL;DR: The results support previous studies in suggesting that the apo E allele epsilon 4 is a risk factor for atherosclerosis, which affects plasma total and LDL-cholesterol and suggest that the APO E allele determines the severity of CAD.
Journal ArticleDOI
Fetal Growth and Preterm Birth Influence Cardiovascular Risk Factors and Arterial Health in Young Adults The Cardiovascular Risk in Young Finns Study
Michael R. Skilton,Jorma Viikari,Markus Juonala,Tomi Laitinen,Terho Lehtimäki,Leena Taittonen,Mika Kähönen,David S. Celermajer,Olli T. Raitakari +8 more
TL;DR: Impaired fetal growth is associated with impaired endothelial function and elevated preclinical atherosclerosis in young adults, partly mediated by inflammation, blood pressure, and triglycerides, most marked for those also born preterm.
Journal ArticleDOI
Common variants at 12q15 and 12q24 are associated with infant head circumference
H. Rob Taal,Beate St Pourcain,Elisabeth Thiering,Shikta Das,Dennis O. Mook-Kanamori,Dennis O. Mook-Kanamori,Nicole M. Warrington,Nicole M. Warrington,Marika Kaakinen,Eskil Kreiner-Møller,Jonathan P. Bradfield,Rachel M. Freathy,Rachel M. Freathy,Frank Geller,Mònica Guxens,Diana L. Cousminer,Marjan Kerkhof,Nicholas J. Timpson,M. Arfan Ikram,Lawrence J. Beilin,Klaus Bønnelykke,Jessica L. Buxton,Pimphen Charoen,Pimphen Charoen,Bo L. Chawes,Johan G. Eriksson,Johan G. Eriksson,David M. Evans,Albert Hofman,John P. Kemp,Cecilia E. Kim,Norman Klopp,Jari Lahti,Stephen J. Lye,George McMahon,Frank D. Mentch,Martina Müller-Nurasyid,Paul F. O'Reilly,Inga Prokopenko,Fernando Rivadeneira,Eric A.P. Steegers,Jordi Sunyer,Carla M. T. Tiesler,Hanieh Yaghootkar,Myriam Fornage,Albert V. Smith,Albert V. Smith,Sudha Seshadri,Reinhold Schmidt,Reinhold Schmidt,Stéphanie Debette,Stéphanie Debette,Stéphanie Debette,Henri Vrooman,Henri Vrooman,Sigurdur Sigurdsson,Stefan Ropele,Laura H. Coker,W. T. Longstreth,W. T. Longstreth,Wiro J. Niessen,Wiro J. Niessen,Wiro J. Niessen,Anita L. DeStefano,Anita L. DeStefano,Alexa S. Beiser,Alexa S. Beiser,Alex P. Zijdenbos,Maksim Struchalin,Clifford R. Jack,Michael A. Nalls,Rhoda Au,Rhoda Au,Haukur Gudnason,Aad van der Lugt,Tamara B. Harris,William M. Meeks,Meike W. Vernooij,Mark A. van Buchem,Diane J. Catellier,Vilmundur Gudnason,Vilmundur Gudnason,B. Gwen Windham,Philip A. Wolf,Cornelia M. van Duijn,Thomas H. Mosley,Thomas H. Mosley,Helena Schmidt,Lenore J. Launer,Lenore J. Launer,Monique M.B. Breteler,Wei Ang,Toos C. E. M. van Beijsterveldt,Toos C. E. M. van Beijsterveldt,Nienke E. Bergen,Kelly S. Benke,Diane Berry,Lachlan J. M. Coin,Paul Elliott,Timothy M. Frayling,Romy Gaillard,Maria M. Groen-Blokhuis,Maria M. Groen-Blokhuis,Dexter Hadley,Jouke-Jan Hottenga,Ville Huikari,Elina Hyppönen,Elina Hyppönen,Matthew Kowgier,Debbie A Lawlor,Alex Lewin,Cecilia M. Lindgren,Julie A. Marsh,Christel M. Middeldorp,Iona Y. Millwood,Iona Y. Millwood,Michel G. Nivard,Lyle J. Palmer,Lyle J. Palmer,Alina Rodriguez,Alina Rodriguez,Alina Rodriguez,Sylvain Sebert,Ulla Sovio,Ulla Sovio,Marie Standl,David P. Strachan,André G. Uitterlinden,Beatriz Valcarcel,Scott W. White,Gonneke Willemsen,Dorret I. Boomsma,Xavier Estivill,Struan F.A. Grant,Andrew T. Hattersley,Joachim Heinrich,Vincent W. V. Jaddoe,Marjo-Riitta Järvelin,Mark I. McCarthy,Craig E. Pennell,C Power,E. Widen,E. Widen,Alexandra I. F. Blakemore,Rosetta M. Chiavacci,Bjarke Feenstra,Julio Fernandez-Banet,Anna-Liisa Hartikainen,Albert J. van der Heijden,Carmen Iñiguez,Mark Lathrop,Wendy L. McArdle,Anne Mølgaard,John P. Newnham,Aarno Palotie,Aarno Palotie,Aarno Palotie,A Pouta,A Pouta,Susan M. Ring,H.-Erich Wichmann,Nadja Hawwa Vissing,Charles DeCarli,Charles DeCarli,Gerard H. Koppelman,Mads Melbye,Hans Bisgaard,Hakon Hakonarson,Hakon Hakonarson,Hakon Hakonarson,George Davey Smith,George Davey Smith,Linda S. Adair,Mustafa Atalay,Oliver S. P. Davis,Claudia Flexeder,Liang Kee Goh,Liang Kee Goh,Claire M. A. Haworth,Johannes Hedebrand,Anke Hinney,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,John W. Holloway,Claus Holst,Momoko Horikoshi,Tuomas O. Kilpeläinen,Mirna Kirin,Hanna Maaria Lakka,Leslie A. Lange,Terho Lehtimäki,Terho Lehtimäki,Virpi Lindi,Reedik Maggi,Reedik Maggi,Jeffrey C. Murray,Ellen Aagaard Nohr,Ioanna Ntalla,Emily Oken,Emily Oken,Emily Oken,Kalliope Panoutsopoulou,Jennifer Pararajasingham,Rany M. Salem,Rany M. Salem,Rany M. Salem,Niina Siitonen,Yik Y. Teo,Eleftheria Zeggini,Cyrus Cooper,Matthew H. Gillman,Berthold Hocher,Berthold Hocher,Timo A. Lakka,Karen L. Mohlke,George Dedoussis,Ken K. Ong,Ewan R. Pearson,Thomas S. Price,Olli T. Raitakari,Olli T. Raitakari,Seang-Mei Saw,André Scherag,Olli Simell,Olli Simell,Thorkild I.A. Sørensen,Thorkild I.A. Sørensen,James F. Wilson,James F. Wilson,James F. Wilson +230 more
TL;DR: This article performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089).
Posted Content
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Magnus Johannesson,David Laibson,Sarah E. Medland,Michelle N. Meyer,Joseph K. Pickrell,Tõnu Esko,Robert F. Krueger,Jonathan P. Beauchamp,Philipp Koellinger,Daniel J. Benjamin,Meike Bartels,David Cesarini,Aysu Okbay,Bart M. L. Baselmans,Jan-Emmanuel De Neve,Patrick Turley,Michel G. Nivard,Mark Alan Fontana,S. Fleur W. Meddens,Richard Karlsson Linnér,Cornelius A. Rietveld,Jaime Derringer,Jacob Gratten,James J. Lee,Jimmy Z. Liu,Ronald de Vlaming,Tarunveer S. Ahluwalia,Jadwiga Buchwald,Alana Cavadino,Alexis C. Frazier-Wood,Nicholas A. Furlotte,Victoria Garfield,Marie Henrike Geisel,Juan R. González,Saskia Haitjema,Robert Karlsson,Sander W. van der Laan,Karl-Heinz Ladwig,Jari Lahti,Sven J. van der Lee,Penelope A. Lind,Tian Liu,Lindsay K. Matteson,Evelin Mihailov,Michael B. Miller,Camelia C. Minică,Ilja M. Nolte,Dennis O. Mook-Kanamori,Peter J. van der Most,Christopher Oldmeadow,Yong Qian,Olli T. Raitakari,Rajesh Rawal,Anu Realo,Rico Rueedi,Börge Schmidt,Albert V. Smith,Evie Stergiakouli,Toshiko Tanaka,Kent D. Taylor,Gudmar Thorleifsson,Juho Wedenoja,Juergen Wellmann,Harm-Jan Westra,Sara M. Willems,Wei Zhao,Najaf Amin,Andrew Bakshi,Sven Bergmann,Gyda Bjornsdottir,Patricia A. Boyle,Samantha Cherney,Simon R. Cox,Gail Davies,Oliver S. P. Davis,Jun Ding,Nese Direk,Peter Eibich,Rebecca T. Emeny,Ghazaleh Fatemifar,Jessica D. Faul,Luigi Ferrucci,Andreas J. Forstner,Christian Gieger,Richa Gupta,Tamara B. Harris,Juliette Harris,Elizabeth G. Holliday,Jouke-Jan Hottenga,Philip L. De Jager,Marika Kaakinen,Eero Kajantie,Ville Karhunen,Ivana Kolcic,Meena Kumari,Lenore J. Launer,Lude Franke,Ruifang Li-Gao,David C. Liewald,Marisa Koini,Anu Loukola,Pedro Marques-Vidal,Grant W. Montgomery,Miriam A. Mosing,Lavinia Paternoster,Alison Pattie,K. Petrovic,Laura Pulkki-Rr Aback,Lydia Quaye,Katri Räikkönen,Igor Rudan,Rodney J. Scott,Jennifer A. Smith,Angelina R. Sutin,Maciej Trzaskowski,Anna A. E. Vinkhuyzen,Lei Yu,Delilah Zabaneh,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Dorret I. Boomsma,Harold Snieder,Shun-Chiao Chang,Francesco Cucca,Ian J. Deary,Cornelia M. van Duijn,Johan G. Eriksson,Ute Bültmann,Eco J. C. de Geus,Patrick J. F. Groenen,Vilmundur Gudnason,Torben Hansen,C.A. Hartman,Claire M. A. Haworth,Caroline Hayward,Andrew C. Heath,David A. Hinds,Elina Hyppönen,William G. Iacono,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Liisa Keltikangas-Järvinen,Peter Kraft,Laura D. Kubzansky,Terho Lehtimäki,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Andres Metspalu,Melinda Mills,Renée de Mutsert,Albertine J. Oldehinkel,Gerard Pasterkamp,Nancy L. Pedersen,Robert Plomin,Ozren Polasek,Christine Power,Stephen S. Rich,Frits R. Rosendaal,Hester M. den Ruijter,David Schlessinger,Helena Schmidt,Rauli Svento,Reinhold Schmidt,Behrooz Z. Alizadeh,Thorkild I. A. Sørensen,Tim D. Spector,John M. Starr,Kari Stefansson,Andrew Steptoe,Antonio Terracciano,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Peter Vollenweider,Gert G. Wagner,David R. Weir,Jian Yang,Dalton Conley,George Davey Smith,Albert Hofman +186 more
TL;DR: In this paper, the authors conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n= 161,460), and neuroticism(n = 170,911).