Terho Lehtimäki

TL;DR: Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new, and integrates gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.

TL;DR: A positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake is suggested and insight is offered into potential link between FTO, dietaryprotein intake and adiposity.

TL;DR: In this article, the authors studied eight prospective cohorts with 22,623 participants profiled by nuclear magnetic resonance or mass spectrometry metabolomics and found that three branched-chain amino acids (isoleucine, leucine and valine), creatinine and two very low density lipoprotein (VLDL)-specific lipid subclasses were associated with lower dementia risk.

TL;DR: Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.

TL;DR: High-throughput metabolite quantification, with new systemic biomarkers, improved risk stratification for subclinical atherosclerosis in comparison to conventional lipids and could potentially be useful for early cardiovascular risk assessment.