T
Terho Lehtimäki
Researcher at University of Tampere
Publications - 1375
Citations - 129159
Terho Lehtimäki is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 142, co-authored 1304 publications receiving 106981 citations. Previous affiliations of Terho Lehtimäki include Boston University & National Institutes of Health.
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Journal ArticleDOI
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.
Jordi Merino,Jordi Merino,Hassan S. Dashti,Hassan S. Dashti,Sherly X. Li,Chloé Sarnowski,Anne E. Justice,Anne E. Justice,Misa Graff,Constantina Papoutsakis,Caren E. Smith,George Dedoussis,Rozenn N. Lemaitre,Mary K. Wojczynski,Satu Männistö,Julius S. Ngwa,Julius S. Ngwa,Minjung Kho,Tarunveer S. Ahluwalia,Natalia Pervjakova,Denise K. Houston,Claude Bouchard,Tao Huang,Marju Orho-Melander,Alexis C. Frazier-Wood,Dennis O. Mook-Kanamori,Louis Pérusse,Craig E. Pennell,Paul S. de Vries,Trudy Voortman,Olivia Li,Stavroula Kanoni,Lynda M. Rose,Terho Lehtimäki,Jing Hua Zhao,Mary F. Feitosa,Jian'an Luan,Nicola M. McKeown,Jennifer A. Smith,Torben Hansen,Niina Eklund,Mike A. Nalls,Tuomo Rankinen,Jinyan Huang,Dena G. Hernandez,Christina-Alexandra Schulz,Ani Manichaikul,Ruifang Li-Gao,Marie-Claude Vohl,Carol A. Wang,Frank J. A. van Rooij,Jean Shin,Ioanna P. Kalafati,Felix R. Day,Paul M. Ridker,Mika Kähönen,David S. Siscovick,Claudia Langenberg,Wei Zhao,Arne Astrup,Paul Knekt,Melissa E. Garcia,Dabeeru C. Rao,Qibin Qi,Luigi Ferrucci,Ulrika Ericson,John Blangero,Albert Hofman,Albert Hofman,Zdenka Pausova,Vera Mikkilä,Nicholas J. Wareham,Sharon L.R. Kardia,Oluf Pedersen,Antti Jula,Joanne E. Curran,M. Carola Zillikens,Jorma Viikari,Nita G. Forouhi,Jose M. Ordovas,Jose M. Ordovas,Jose M. Ordovas,John C. Lieske,Harri Rissanen,André G. Uitterlinden,Olli T. Raitakari,Jessica C. Kiefte-de Jong,Jessica C. Kiefte-de Jong,Josée Dupuis,Jerome I. Rotter,Kari E. North,Robert A. Scott,Michael A. Province,Markus Perola,L. Adrienne Cupples,L. Adrienne Cupples,Stephen Turner,Thorkild I. A. Sørensen,Veikko Salomaa,Yongmei Liu,Yun J. Sung,Lu Qi,Stefania Bandinelli,Stephen S. Rich,Renée de Mutsert,Angelo Tremblay,Wendy H. Oddy,Wendy H. Oddy,Oscar H. Franco,Tomáš Paus,Tomáš Paus,Jose C. Florez,Jose C. Florez,Panos Deloukas,Panos Deloukas,Leo-Pekka Lyytikäinen,Daniel I. Chasman,Audrey Y. Chu,Toshiko Tanaka +118 more
TL;DR: 12 suggestively significant loci are identified associated with intake of any macronutrient in 91,114 European ancestry participants, corroborating earlier FGF21 and FTO findings and providing new insight into biological functions related to macronsutrient intake.
Journal ArticleDOI
Mendelian Randomization Suggests No Causal Association Between C-reactive Protein and Carotid Intima-media Thickness in the Young Finns Study
Mika Kivimäki,Debbie A Lawlor,Carita Eklund,George Davey Smith,Mikko Hurme,Terho Lehtimäki,Jorma Viikari,Olli T. Raitakari +7 more
TL;DR: To the Editor: It is unclear whether C-reactive protein (CRP), a nonspecific marker of acute phase inflammatory response, is causally related to arterial intima-media thickness (IMT), a risk factor for coronary heart disease (CHD).
Journal ArticleDOI
Polymorphism of the cytokine genes and IgA nephropathy
TL;DR: Carriage of IL1beta2 and IL1RN*2 together with non-carriage of TNF2 is associated with increased susceptibility, but not with a prognosis of IgAN.
Journal ArticleDOI
C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study.
Carita Eklund,Mika Kivimäki,Mika Kivimäki,Md. Shaheenul Islam,Md. Shaheenul Islam,Markus Juonala,Mika Kähönen,Jukka Marniemi,Terho Lehtimäki,Jorma Viikari,Olli T. Raitakari,M Hurme +11 more
TL;DR: The data suggest that the presence of high producer CRP genotype is deleterious to carotid elasticity in men, and this work aims to determine if CRP gene polymorphisms or haplotypes are associated with CRP concentration or carOTid artery compliance (CAC), an indicator of subclinical atherosclerosis.
Journal ArticleDOI
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits
Nathan Pankratz,Ursula M. Schick,Yi Zhou,Wei Zhou,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Maria L. Allende,Paul L. Auer,Jette Bork-Jensen,Jennifer A. Brody,Ming-Huei Chen,Vinna Clavo,John D. Eicher,Niels Grarup,Elliott J. Hagedorn,Bella Hu,Kristina L. Hunker,Andrew D. Johnson,Maarten Leusink,Yingchang Lu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Riccardo E. Marioni,Mike A. Nalls,Raha Pazoki,Albert V. Smith,Frank J. A. van Rooij,Min-Lee Yang,Xiaoling Zhang,Yan Zhang,Folkert W. Asselbergs,Eric Boerwinkle,Ingrid B. Borecki,Erwin P. Bottinger,Mary Cushman,Paul I.W. de Bakker,Ian J. Deary,Liguang Dong,Mary F. Feitosa,James S. Floyd,Nora Franceschini,Oscar H. Franco,Melissa E. Garcia,Megan L. Grove,Vilmundur Gudnason,Torben Hansen,Tamara B. Harris,Albert Hofman,Albert Hofman,Rebecca D. Jackson,Jia Jia,Mika Kähönen,Lenore J. Launer,Terho Lehtimäki,David C. Liewald,Allan Linneberg,Yongmei Liu,Ruth J. F. Loos,Vy M. Nguyen,Mattijs E. Numans,Mattijs E. Numans,Oluf Pedersen,Bruce M. Psaty,Olli T. Raitakari,Stephen S. Rich,Fernando Rivadeneira,Amanda M Rosa Di Sant,Jerome I. Rotter,John M. Starr,Kent D. Taylor,Betina Heinsbek Thuesen,Russell P. Tracy,André G. Uitterlinden,Jiansong Wang,Judy Wang,Abbas Dehghan,Yong Huo,L. Adrienne Cupples,James G. Wilson,Richard L. Proia,Leonard I. Zon,Christopher J. O'Donnell,Alexander P. Reiner,Santhi K. Ganesh +83 more
TL;DR: The association of a rare missense variant in S1PR4 supports the role of sphingosine-1-phosphate signaling in leukocyte trafficking and circulating neutrophil counts and loss-of-function experiments for S1pr4 in mouse and s1 Pr4 in zebrafish demonstrated phenotypes consistent with the association observed in humans.