Aligarh Muslim University

About: Aligarh Muslim University is a education organization based out in Aligarh, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Adsorption. The organization has 8218 authors who have published 16416 publications receiving 289068 citations. The organization is also known as: AMU.

Salicylic Acid: Biosynthesis, Metabolism and Physiological Role in Plants

Abstract: Salicylic acid (SA) is a phenolic derivative, distributed in a wide range of plant species. It is a natural product of phenylpropanoid metabolism. Decarboxylation of transcinnamic acid to benzoic acid and its subsequent 2-hydroxylation results to SA. It undergoes metabolism by conjugating with glucose to SA glucoside and an ester. SA has direct involvement in plant growth, thermogenesis, flower induction and uptake of ions. It affects ethylene biosynthesis, stomatal movement and also reverses the effects of ABA on leaf abscission. Enhancement of the level of chlorophyll and carotenoid pigments, photosynthetic rate and modifying the activity of some of the important enzymes are other roles assigned to SA. This chapter gives a comprehensive coverage to all the above aspects.

Cancer Multidrug Resistance (MDR): A Major Impediment to Effective Chemotherapy

Abstract: Multidrug resistance (MDR) continues to be a major challenge to effective chemotherapeutic interventions against cancer. Various types of cancers have been observed to exhibit this phenomenon, a strategy that involves cellular and non cellular mechanisms employed by cancer cells to survive the cytotoxic actions of various structurally and functionally unrelated drugs. The present article is a brief review of the fundamental mechanisms underlying the phenomenon of MDR in cancer cells and some novel approaches addressed at its inhibition, circumvention or reversal. The emergence of natural products as potential anti-MDR molecules is of particular significance. Since many of these are essential components of the human diet, they are expected to possess fewer side effects and may possibly represent a new generation of MDR modulators.