Case Western Reserve University

About: Case Western Reserve University is a education organization based out in Cleveland, Ohio, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 54617 authors who have published 106568 publications receiving 5071613 citations. The organization is also known as: Case & Case Western.

A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

Abstract: Background Adenotonsillectomy is commonly performed in children with the obstructive sleep apnea syndrome, yet its usefulness in reducing symptoms and improving cognition, behavior, quality of life, and polysomnographic findings has not been rigorously evaluated. We hypothesized that, in children with the obstructive sleep apnea syndrome without prolonged oxyhemoglobin desaturation, early adenotonsillectomy, as compared with watchful waiting with supportive care, would result in improved outcomes. Methods We randomly assigned 464 children, 5 to 9 years of age, with the obstructive sleep apnea syndrome to early adenotonsillectomy or a strategy of watchful waiting. Polysomnographic, cognitive, behavioral, and health outcomes were assessed at baseline and at 7 months. Results The average baseline value for the primary outcome, the attention and executive-function score on the Developmental Neuropsychological Assessment (with scores ranging from 50 to 150 and higher scores indicating better functioning), was ...

Controllability, stabilizability, and continuous-time Markovian jump linear quadratic control

Abstract: Consideration is given to the control of continuous-time linear systems that possess randomly jumping parameters which can be described by finite-state Markov processes. The relationship between appropriately defined controllability, stabilizability properties, and the solution of the infinite time jump linear quadratic (JLQ) optimal control problems is also examined. Although the solution of the continuous-time Markov JLQ problem with finite or infinite time horizons is known, only sufficient conditions for the existence of finite cost, constant, stabilizing controls for the infinite time problem appear in the literature. In this paper necessary and sufficient conditions are established. These conditions are based on new definitions of controllability, observability, stabilizability, and detectability that are appropriate for continuous-time Markovian jump linear systems. These definitions play the same role for the JLQ problem as the deterministic properties do for the linear quadratic regulator (LQR) problem. >

Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement

Abstract: Context.—The value of placental examination in investigations of adverse pregnancy outcomes may be compromised by sampling and definition differences between laboratories. Objective.—To establish an agreed-upon protocol for sampling the placenta, and for diagnostic criteria for placental lesions. Recommendations would cover reporting placentas in tertiary centers as well as in community hospitals and district general hospitals, and are also relevant to the scientific research community. Data Sources.—Areas of controversy or uncertainty were explored prior to a 1-day meeting where placental and perinatal pathologists, and maternal-fetal medicine specialists discussed available evidence and subsequently reached consensus where possible. Conclusions.—The group agreed on sets of uniform sampling criteria, placental gross descriptors, pathologic terminologies, and diagnostic criteria. The terminology and microscopic descriptions for maternal vascular malperfusion, fetal vascular malperfusion, delayed villous m...