Institution
Keele University
Education•Newcastle-under-Lyme, United Kingdom•
About: Keele University is a education organization based out in Newcastle-under-Lyme, United Kingdom. It is known for research contribution in the topics: Population & Stars. The organization has 11318 authors who have published 26323 publications receiving 894671 citations. The organization is also known as: Keele University.
Topics: Population, Stars, Health care, Context (language use), Politics
Papers published on a yearly basis
Papers
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TL;DR: In this article, the effect of variable vacuum width and slab thickness on the predicted surface energy and surface atomic displacements was investigated, and it was shown that vacuum widths of only 4 A are sufficient to converge the surface energy to within 0.01 J m−2.
211 citations
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TL;DR: It is concluded that expression of full-length SMN in neurons can correct the severe SMA phenotype in mice, and a small increase of SMn in neurons has a substantial impact on survival of SMA mice while high SMN levels in mature skeletal muscle alone has no impact.
Abstract: Spinal muscular atrophy (SMA) is caused by loss of the survival motor neuron gene (SMN1) and retention of the SMN2 gene. The copy number of SMN2 affects the amount of SMN protein produced and the severity of the SMA phenotype. While loss of mouse Smn is embryonic lethal, two copies of SMN2 prevents this embryonic lethality resulting in a mouse with severe SMA that dies 5 days after birth. Here we show that expression of full-length SMN under the prion promoter (PrP) rescues severe SMA mice. The PrP results in high levels of SMN in neurons at embryonic day 15. Mice homozygous for PrP-SMN with two copies of SMN2 and lacking mouse Smn survive for an average of 210 days and lumbar motor neuron root counts in these mice were normal. Expression of SMN solely in skeletal muscle using the human skeletal actin (HSA) promoter resulted in no improvement of the SMA phenotype or extension of survival. One HSA line displaying nerve expression of SMN did affect the SMA phenotype with mice living for an average of 160 days. Thus, we conclude that expression of full-length SMN in neurons can correct the severe SMA phenotype in mice. Furthermore, a small increase of SMN in neurons has a substantial impact on survival of SMA mice while high SMN levels in mature skeletal muscle alone has no impact.
211 citations
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TL;DR: In this paper, the spatial variations in trace element (Sr, Mg and P) concentrations in speleothems (a stalagmite and a soda straw stalactite) from the alpine Ernesto cave (temperature 6.6±0.1°C) in a forested catchment in NE Italy have been studied using secondary ion mass spectrometry (SIMS) and compared with environmental parameters and waters in the modern cave.
211 citations
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TL;DR: As discussed in this Review, turgor and pressure have additional roles in hyphal growth, such as causing the mass flow of cytoplasm from the basal mycelial network towards the expanding hyphal tips at the colony edge.
Abstract: The mechanisms underlying the growth of fungal hyphae are rooted in the physical property of cell pressure. Internal hydrostatic pressure (turgor) is one of the major forces driving the localized expansion at the hyphal tip which causes the characteristic filamentous shape of the hypha. Calcium gradients regulate tip growth, and secretory vesicles that contribute to this process are actively transported to the growing tip by molecular motors that move along cytoskeletal structures. Turgor is controlled by an osmotic mitogen-activated protein kinase cascade that causes de novo synthesis of osmolytes and uptake of ions from the external medium. However, as discussed in this Review, turgor and pressure have additional roles in hyphal growth, such as causing the mass flow of cytoplasm from the basal mycelial network towards the expanding hyphal tips at the colony edge.
210 citations
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TL;DR: In this paper, the authors examined the effect of upland surficial aquifer size, topography and riparian sediment lithology on the subsurface hydrology of eight riparian sites on glacial till and outwash landscapes in southern Ontario, Canada.
210 citations
Authors
Showing all 11402 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
Simon D. M. White | 189 | 795 | 231645 |
James F. Wilson | 146 | 677 | 101883 |
Stephen O'Rahilly | 138 | 520 | 75686 |
Wendy Taylor | 131 | 1252 | 89457 |
Nicola Maffulli | 115 | 1570 | 59548 |
Georg Kresse | 111 | 430 | 244729 |
Patrick B. Hall | 111 | 470 | 68383 |
Peter T. Katzmarzyk | 110 | 618 | 56484 |
John F. Dovidio | 109 | 466 | 46982 |
Elizabeth H. Blackburn | 108 | 344 | 50726 |
Mary L. Phillips | 105 | 422 | 39995 |
Garry P. Nolan | 104 | 474 | 46025 |
Wayne W. Hancock | 103 | 505 | 35694 |
Mohamed H. Sayegh | 103 | 485 | 38540 |