Institution
National Autonomous University of Nicaragua
Education•Managua, Nicaragua•
About: National Autonomous University of Nicaragua is a education organization based out in Managua, Nicaragua. It is known for research contribution in the topics: Population & Public health. The organization has 775 authors who have published 715 publications receiving 9791 citations.
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TL;DR: Heat stress, dehydration and kidney dysfunction were most common among sugarcane cutters, andKidney dysfunction also occurred to a lesser extent among construction workers, but hardly at all among small-scale farmers.
Abstract: Objectives To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations. Design Cross-sectional. Setting Chinandega and Leon municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January–February 2013. Participants 194 male workers aged 17–39 years: 86 sugarcane cutters, 56 construction workers, 52 small-scale farmers. Outcome measures (1) Differences between the three occupational groups in prevalences/levels of socioeconomic, occupational, lifestyle and health risk factors for chronic kidney disease (CKD) and in biomarkers of kidney function and hydration; (2) differences in prevalences/levels of CKD risk factors between workers with reduced estimated glomerular filtration rate (eGFR CKD-EPI 2 ) and workers with normal kidney function (eGFR CKD-EPI ≥80 mL/min/1.73 m 2 ). Results Sugarcane cutters were more exposed to heat and consumed more fluid on workdays and had less obesity, lower blood sugar, lower blood pressure and a better lipid profile. Reduced eGFR occurred in 16%, 9% and 2% of sugarcane cutters, construction workers and farmers, respectively (trend cane > construction > farming, p=0.003). Significant trends (cane > construction > farming) were also observed for high serum urea nitrogen (blood urea nitrogen (BUN) >20 mg/dL), high serum creatinine (SCr >1.2 mg/dL), low urinary pH (≤5.5) and high BUN/SCr ratio (>20) but not for high urinary specific gravity (≥1.030). Sugarcane cutters also more often had proteinuria and blood and leucocytes in the urine. Workers with eGFR 2 reported a higher intake of water and lower intake of sugary beverages. Serum uric acid levels related strongly and inversely to eGFR levels (adj β −10.4 mL/min/1.73 m 2 , 95% CI −12.2 to −8.5, p 2 , p=0.09). Conclusions Heat stress, dehydration and kidney dysfunction were most common among sugarcane cutters. Kidney dysfunction also occurred to a lesser extent among construction workers, but hardly at all among small-scale farmers. High serum uric acid was associated with reduced kidney function.
119 citations
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Takeda Pharmaceutical Company1, Research Institute for Tropical Medicine2, La Salle University3, University of Colombo4, Obras Sociais Irmã Dulce5, University of Kelaniya6, University of Sri Jayewardenepura7, Khon Kaen University8, National Autonomous University of Nicaragua9, University of Valle10, University of the Philippines Manila11
TL;DR: TAK-003 was well tolerated and efficacious against symptomatic dengue in children regardless of serostatus before immunisation, warranting continued follow-up to assess longer-term vaccine performance.
109 citations
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TL;DR: The "10-group" or "Robson" classification could help identify which groups of women are contributing most to the high caesarean section rates in Latin America, and if it could provide information useful for health care providers in monitoring and planning effective actions to reduce these rates.
Abstract: Caesarean section rates continue to increase worldwide with uncertain medical consequences. Auditing and analysing caesarean section rates and other perinatal outcomes in a reliable and continuous manner is critical for understanding reasons caesarean section changes over time. We analyzed data on 97,095 women delivering in 120 facilities in 8 countries, collected as part of the 2004-2005 Global Survey on Maternal and Perinatal Health in Latin America. The objective of this analysis was to test if the "10-group" or "Robson" classification could help identify which groups of women are contributing most to the high caesarean section rates in Latin America, and if it could provide information useful for health care providers in monitoring and planning effective actions to reduce these rates. The overall rate of caesarean section was 35.4%. Women with single cephalic pregnancy at term without previous caesarean section who entered into labour spontaneously (groups 1 and 3) represented 60% of the total obstetric population. Although women with a term singleton cephalic pregnancy with a previous caesarean section (group 5) represented only 11.4% of the obstetric population, this group was the largest contributor to the overall caesarean section rate (26.7% of all the caesarean sections). The second and third largest contributors to the overall caesarean section rate were nulliparous women with single cephalic pregnancy at term either in spontaneous labour (group 1) or induced or delivered by caesarean section before labour (group 2), which were responsible for 18.3% and 15.3% of all caesarean deliveries, respectively. The 10-group classification could be easily applied to a multicountry dataset without problems of inconsistencies or misclassification. Specific groups of women were clearly identified as the main contributors to the overall caesarean section rate. This classification could help health care providers to plan practical and effective actions targeting specific groups of women to improve maternal and perinatal care.
105 citations
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TL;DR: A greedy randomised adaptive search procedure (GRASP) which is very fast and obtains good results for both constrained and unconstrained problems, and a more complex tabu search algorithm that obtains high quality results in moderate computing times.
105 citations
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TL;DR: Results of this study suggested that the protective effect of magnesium on vascular calcification was not limited to its action as an intestinal phosphate binder since magnesium administered intraperitoneally also decreased vascular calcifying.
95 citations
Authors
Showing all 782 results
Name | H-index | Papers | Citations |
---|---|---|---|
José A. G. Agúndez | 49 | 270 | 8893 |
Adrián LLerena | 43 | 226 | 6276 |
Julio Benítez | 40 | 108 | 4357 |
Noemí Castro | 30 | 98 | 2183 |
Carolina González | 21 | 63 | 1395 |
Filemon Bucardo | 21 | 54 | 1507 |
Rodolfo Peña | 21 | 39 | 2792 |
Juan Jovel | 20 | 58 | 2235 |
Eliette Valladares | 19 | 35 | 3048 |
Margarita Paniagua | 17 | 24 | 935 |
Carlos M. Vilas | 16 | 124 | 982 |
Aurora Aragón | 16 | 33 | 1073 |
Michael H. Carstens | 16 | 37 | 1128 |
Sonia Panadero | 14 | 41 | 422 |
Ricardo L. Dominguez | 14 | 39 | 1024 |