Institution
Rio de Janeiro State University
Education•Rio de Janeiro, Brazil•
About: Rio de Janeiro State University is a education organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 16631 authors who have published 30919 publications receiving 465753 citations. The organization is also known as: UERJ & Rio de Janeiro State University.
Papers published on a yearly basis
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Victoria Police1, Erasmus University Rotterdam2, University of the Punjab3, American Board of Legal Medicine4, Wellcome Trust Sanger Institute5, University of Ljubljana6, University of Central Florida7, King's College London8, Innsbruck Medical University9, University of Buenos Aires10, University of Zurich11, University of Turin12, University of Santiago de Compostela13, Rio de Janeiro State University14, National Institute of Standards and Technology15, Pompeu Fabra University16, University of the Western Cape17, Leiden University Medical Center18, University of the Philippines Diliman19, Katholieke Universiteit Leuven20, Wrocław Medical University21, Norwegian Institute of Public Health22, University of Benghazi23, Gdańsk Medical University24, University of Madeira25, Netherlands Forensic Institute26, Linköping University27, University of Tsukuba28, Martin Luther University of Halle-Wittenberg29, National Research Institute of Police Science30, University of Leicester31, Dankook University32, University of Salzburg33, University of Sarajevo34, Aristotle University of Thessaloniki35, Medical University of Warsaw36, Yonsei University37, University of Aveiro38, University of Copenhagen39, Central Forensic Science Laboratory40, Centre for DNA Fingerprinting and Diagnostics41, Kunming Medical University42, Royal Thai Police43, Marche Polytechnic University44, University of Helsinki45, Pennsylvania State University46, University of New Haven47, Josip Juraj Strossmayer University of Osijek48, Eijkman Institute for Molecular Biology49, Charité50, University of Guadalajara51, Mahidol University52, University of North Texas Health Science Center53, University of Cologne54, Comenius University in Bratislava55, University of Costa Rica56, Flinders University57, Charles University in Prague58, DSO National Laboratories59
TL;DR: The value of RM Y‐STRs in identifying and separating unrelated and related males and providing a reference database is demonstrated and the value of Y‐ STRs relative to Yfiler is demonstrated.
Abstract: Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
155 citations
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TL;DR: The data point to the high prevalence of Shiga toxin-producing Escherichia coli (STEC) strains in the authors' environment and suggest the need for good control strategies for the prevention of contamination of animal products.
155 citations
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TL;DR: In this paper, a search for new physics in the final state containing a photon and missing transverse energy was conducted, and the authors set 90% confidence level (CL) upper limits for spin-dependent chi-nucleon scattering for chi masses between 1 and 100 GeV.
Abstract: Results are presented from a search for new physics in the final state containing a photon and missing transverse energy. The data correspond to an integrated luminosity of 5.0 inverse femtobarns collected in pp collisions at sqrt(s)=7 TeV by the CMS experiment. The observed event yield agrees with standard-model expectations for photon plus missing transverse energy events. Using models for production of dark-matter particles (chi), we set 90% confidence level (CL) upper limits of 13.6--15.4 femtobarns on chi production in the photon plus missing transverse energy state. These provide the most sensitive upper limits for spin-dependent chi-nucleon scattering for chi masses between 1 and 100 GeV. For spin-independent contributions, the present limits are extended to chi masses below 3.5 GeV. For models with 3--6 large extra dimensions, our data exclude extra-dimensional Planck scales between 1.65 and 1.71 TeV at 95% CL.
155 citations
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TL;DR: This paper carried out in situ U-Pb and Lu-Hf isotope analyses of detrital zircons from the Mississippi River in order to understand crustal reworking and continental growth rates.
Abstract: We carried out in situ U-Pb and Lu-Hf isotope analyses of detrital zircons from the Mississippi River in order to understand crustal reworking and continental growth rates. The U-Pb analyses for 416 zircons reveal three major peaks of crust formation at 2.8–2.6 Ga, 1.8–0.9 Ga, and after 0.2 Ga. Initial Hf isotope ratios were obtained for 402 of the dated zircons, and only 8% of the zircons have \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\ \_{Hf(\mathit{T})\_{DM}}\) \end{document} values less negative than −2.5. These data correspond to a crustal residence time of <120 m.y. This finding indicates that crustal reworking was a very important process in continental crust formation. The \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\ \_{Hf(\mathit{T})\_{DM}}\) \end{document} population demonstrates that reworking was predominant at 2.5–2.0 Ga and after 0.9 Ga, whereas juvenile crust formation dominated between 2.0 and 1.6 Ga. We calculated the mantle-extraction model ages to estimate the continental growth rate. Approximately half of the grains have model ages between 2.0 and 1.3 Ga, indicating rapid crustal growth during this time. The continental growth rate suggests that 15% and 78% crust in the source region of the zircons formed by 2.5 and 1.3 Ga, respectively.
154 citations
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TL;DR: Patients who were receiving standard SLE therapy and had renal, neurologic, or vasculitic involvement, elevated anti-dsDNA or BLyS levels, or low C3 had increased risk of clinically meaningful flare over 1 year.
Abstract: Objective
To identify predictors of moderate-to-severe systemic lupus erythematosus (SLE) flare in 562 patients treated with standard therapy alone in phase III belimumab trials, and to evaluate the impact of standard therapies on preventing flares.
Methods
Post hoc analysis assessed baseline demographics, disease activity, and biomarkers in patients with and those without flare at treatment weeks 24 and 52. Severe flare was defined by the modified SLE Flare Index (SFI) and the development of any new British Isles Lupus Assessment Group (BILAG) A domain score. Severe and moderate flare was defined by development of 1 new BILAG A domain score or 2 new BILAG B domain scores. Baseline characteristics associated with a ≥10% absolute difference or a ≥50% increase in flare rates were considered predictive.
Results
Frequencies of flares over 52 weeks according to the SFI, any new BILAG A domain score, and 1 new BILAG A domain score or 2 new BILAG B domain scores were 23.7%, 23.1%, and 32.0%, respectively. Flare predictors by univariate analysis on all 3 indices at weeks 24 and 52 were a score ≥12 on the Safety of Estrogens in Lupus Erythematosus National Assessment version of the SLE Disease Activity Index (SELENA–SLEDAI); anti–double-stranded DNA (anti-dsDNA) positivity; proteinuria (≥0.5 gm/24 hours); BILAG renal, vasculitic, and hematologic scores; elevated C-reactive protein levels; and B lymphocyte stimulator (BLyS) levels ≥2 ng/ml. Independent predictors by multivariate analysis at week 52 were SELENA–SLEDAI and/or BILAG renal involvement and anti-dsDNA ≥200 IU/ml (on all 3 indices); SELENA–SLEDAI and/or BILAG neurologic and vasculitic involvement (on 2 indices: any new BILAG A domain score and 1 new BILAG A domain score or 2 new BILAG B domain scores); BLyS levels ≥2 ng/ml (on 2 indices: the SFI and 1 new BILAG A domain score or 2 new BILAG B domain scores); and low C3 level (on the SFI). Baseline medications did not significantly decrease or increase moderate-to-severe SLE flare risk.
Conclusion
Patients who were receiving standard SLE therapy and had renal, neurologic, or vasculitic involvement, elevated anti-dsDNA or BLyS levels, or low C3 had increased risk of clinically meaningful flare over 1 year. Hydroxychloroquine use was not predictive.
154 citations
Authors
Showing all 16818 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Maria Elena Pol | 139 | 1414 | 99240 |
Wagner Carvalho | 135 | 1395 | 94184 |
Alberto Santoro | 135 | 1576 | 100629 |
Andre Sznajder | 134 | 1464 | 98242 |
Luiz Mundim | 133 | 1413 | 89792 |
Helio Nogima | 132 | 1274 | 84368 |
D. De Jesus Damiao | 128 | 1162 | 82707 |
Magdalena Malek | 128 | 598 | 67486 |
Sudha Ahuja | 127 | 1016 | 75739 |
Helena Malbouisson | 125 | 1151 | 82692 |
Jose Chinellato | 123 | 1116 | 64267 |
Flavia De Almeida Dias | 120 | 590 | 59083 |
Gilvan Alves | 119 | 829 | 69382 |
C. De Oliveira Martins | 119 | 880 | 66744 |