Institution
Universidade Federal de Minas Gerais
Education•Belo Horizonte, Minas Gerais, Brazil•
About: Universidade Federal de Minas Gerais is a education organization based out in Belo Horizonte, Minas Gerais, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 41631 authors who have published 75688 publications receiving 1249905 citations.
Topics: Population, Context (language use), Medicine, Immune system, Health care
Papers published on a yearly basis
Papers
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TL;DR: An a posteriori addition of a van der Waals term to DFTB is proposed, which provides results for H2/PAH interactions in close agreement with MP2 and higher-level ab initio methods.
Abstract: The performance of density functional theory (DFT) (VWN-LDA, PBE-GGA, and B3LYP hybrid functionals), density-functional-based tight binding (DFTB), and ab initio methods [HF, MP2, CCSD, and CCSD(T)] for the treatment of London dispersion is investigated. Although highly correlated ab initio methods are capable of describing this phenomenon, if they are used with rather large basis sets, DFT methods are found to be inadequate for the description of H2/PAH (polycyclic aromatic hydrocarbon) interactions. As an alternative approach, an a posteriori addition of a van der Waals term to DFTB is proposed. This method provides results for H2/PAH interactions in close agreement with MP2 and higher-level ab initio methods. Bulk properties of graphite also compare well with the experimental data.
276 citations
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TL;DR: Chemokines and mitochondrial products collaborate in neutrophil‐mediated injury and systemic inflammation during acute liver failure and the release of necrotic products into the circulation may trigger a systemic inflammatory response and remote lung injury.
276 citations
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TL;DR: Findings reveal an important function for the gut microbiota in combating systemic infection through the induction of protective IgG, and identified murein lipoprotein (MLP), a highly conserved gram-negative outer membrane protein, as a major antigen that induced systemic IgG homeostatically in both mice and humans.
275 citations
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Queen Mary University of London1, University College London2, Newcastle University3, London Research Institute4, University of Oxford5, Churchill Hospital6, Universidade Federal de Minas Gerais7, Federal University of Rio de Janeiro8, University of Manchester9, University of Tokushima10, Teikyo University11, Hiroshima University12, Carol Davila University of Medicine and Pharmacy13, Derriford Hospital14, University of Alabama at Birmingham15, University of Illinois at Chicago16
TL;DR: The abnormal expression and subcellular localization of AIP in sporadic pituitary adenomas indicate deranged regulation of this protein during tumorigenesis.
Abstract: Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene in familial isolated pituitary adenomas (FIPA) It is not clear, however, how this molecular chaperone is involved in tumorigenesis Objective: AIP sequence changes and expression were studied in FIPA and sporadic adenomas The function of normal and mutated AIP molecules was studied on cell proliferation and protein-protein interaction Cellular and ultrastructural AIP localization was determined in pituitary cells Patients: Twenty-six FIPA kindreds and 85 sporadic pituitary adenoma patients were included in the study Results: Nine families harbored AIP mutations Overexpression of wild-type AIP in TIG3 and HEK293 human fibroblast and GH3 pituitary cell lines dramatically reduced cell proliferation, whereas mutant AIP lost this ability All the mutations led to a disruption of the protein-protein interaction between AIP and phosphodiesterase-4A5 In normal pituitary, AIP colocalizes exclusively with
274 citations
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TL;DR: The results suggest that some F. prausnitzii strains could represent good candidates as next-generation probiotic as well as a deep molecular and metabolic characterization of these isolated strains.
Abstract: Faecalibacterium prausnitzii is a major member of the Firmicutes phylum and one of the most abundant bacteria in the healthy human microbiota. F. prausnitzii depletion has been reported in several intestinal disorders, and more consistently in Crohn’s disease (CD) patients. Despite its importance in human health, only few microbiological studies have been performed to isolate novel F. prausnitzii strains in order to better understand the biodiversity and physiological diversity of this beneficial commensal species. In this study, we described a protocol to isolate novel F. prausnitzii strains from feces of healthy volunteers as well as a deep molecular and metabolic characterization of these isolated strains. These F. prausnitzii strains were classified in two phylogroups and 3 clusters according to 16S rRNA sequences and results support that they would belong to two different genomospecies or genomovars as no genome sequencing has been performed in this work. Differences in enzymes production, antibiotic resistance and immunomodulatory properties were found to be strain-dependent. So far, all F. prausnitzii isolates share some characteristic such as i) the lack of epithelial cells adhesion, plasmids, anti-microbial and hemolytic activity and ii) the presence of DNAse activity. Furthermore, Short Chain Fatty Acids (SCFA) production was assessed for the novel isolates as these products influence intestinal homeostasis. Indeed, the butyrate production has been correlated to the capacity to induce IL-10, an anti-inflammatory cytokine, in peripheral blood mononuclear cells (PBMC) but not to the ability to block IL-8 secretion in TNF-α-stimulated HT-29 cells, reinforcing the hypothesis of a complex anti-inflammatory pathway driven by F. prausnitzii. Altogether, our results suggest that some F. prausnitzii strains could represent good candidates as next-generation probiotic.
274 citations
Authors
Showing all 42077 results
Name | H-index | Papers | Citations |
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Michael Marmot | 193 | 1147 | 170338 |
Pulickel M. Ajayan | 176 | 1223 | 136241 |
Alan D. Lopez | 172 | 863 | 259291 |
Jens Nielsen | 149 | 1752 | 104005 |
Mildred S. Dresselhaus | 136 | 762 | 112525 |
Jing Kong | 126 | 553 | 72354 |
Mauricio Terrones | 118 | 760 | 61202 |
Michael Brammer | 118 | 424 | 46763 |
Terence G. Langdon | 117 | 1158 | 61603 |
Caroline A. Sabin | 108 | 690 | 44233 |
Michael Brauer | 106 | 480 | 73664 |
Michael Bader | 103 | 735 | 37525 |
Michael S. Strano | 98 | 480 | 60141 |
Pablo Jarillo-Herrero | 91 | 245 | 39171 |
Riichiro Saito | 91 | 502 | 48869 |