Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
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TLDR
The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.About:
This article is published in Biological Psychiatry.The article was published on 2010-11-15. It has received 866 citations till now.read more
Citations
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Altered Serum and Cerebrospinal Fluid Inflammatory Cascades in Mild Cognitive Impairment and Alzheimer’s Disease
TL;DR: In the early stages of neurodegeneration, inflammatory factors driving cognitive impairment may be derived more from systemic than CNS responses, and alterations in trophic factor expression may largely originate within the CNS, although they could be propagated by neuroinflammation.
Journal ArticleDOI
Premna odorata extract as a protective agent on neurotoxic effect of aluminum: neurochemical, molecular, and histopathological alterations.
TL;DR: Premna odorata extract could be important in improving and treatment of neurodegenerative disorders as it was able to reduce oxidative stress, DNA damage, biochemical alterations, and histopathological changes in rats exposed to AlCl 3 toxicity.
Journal ArticleDOI
Role of inflammatory and hemostatic biomarkers in Alzheimer's and vascular dementia - A pilot study from a tertiary center in Northern India
Venugopalan Y Vishnu,Manish Modi,Vivek Garg,Manju Mohanty,Manoj Kumar Goyal,Vivek Lal,Bhagwant Rai Mittal,S. Prabhakar +7 more
TL;DR: Hemostatic biomarkers were higher in Vascular group compared to Alzheimer group whereas there was no difference in inflammatory biomarkers.
Journal ArticleDOI
Glibenclamide modulates microglial function and attenuates Aβ deposition in 5XFAD mice.
Yeon-Joo Ju,Namkwon Kim,Min Sung Gee,Seung Ho Jeon,Danbi Lee,Jimin Do,Jong-Sik Ryu,Jong Kil Lee +7 more
TL;DR: The data suggests that glibenclamide may be a therapeutic option for AD treatment and reduces pro-inflammatory cytokines and proteins in the LPS-induced microglial cells.
Journal ArticleDOI
Early inflammation–associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE/PSEN1dE9 mouse model of Alzheimer's disease
TL;DR: Early inflammation–associated factors most likely diminish HFD‐induced hepatic lipid deposition by inhibiting SREBP‐1‐mediated de novo lipogenesis, thus driving substrate flux to glucose production for hyperglycemia and hepatic insulin resistance in T2D development.
References
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Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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