Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
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TLDR
The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.About:
This article is published in Biological Psychiatry.The article was published on 2010-11-15. It has received 866 citations till now.read more
Citations
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Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis.
TL;DR: It is demonstrated that patients with DS are accompanied by increased circulating cytokine tumor necrosis factor-α, IL-1β and interferon-γ levels, strengthening the clinical evidence that patients (children) with DS is accompanied by an abnormal inflammatory response.
Journal ArticleDOI
Alterations in the Peripheral Immune System in Dementia.
Mandy Busse,Enrico Michler,Franz von Hoff,Henrik Dobrowolny,Roland Hartig,Thomas Frodl,Stefan Busse +6 more
TL;DR: The peripheral immune system is altered in AD, VaD, and FTD, however, each disorder presents unique changes in the investigated cell types indicating different mechanisms underlying the pathology.
Journal ArticleDOI
Anesthesia, surgery, illness and Alzheimer's disease
TL;DR: It is highly likely that inflammatory cascades are at the heart of this intersection, and if confirmed, this suggests a therapeutic strategy to mitigate enhanced neuropathology in vulnerable surgical patients.
Journal ArticleDOI
Decreased IL-8 levels in CSF and serum of AD patients and negative correlation of MMSE and IL-1β
Raphael Hesse,Anke Wahler,Pauline Gummert,Stefanie Kirschmer,Markus Otto,Hayrettin Tumani,Jan Lewerenz,Cathrin Schnack,Christine A. F. von Arnim +8 more
TL;DR: The results confirm data suggesting that cytokine alterations are involved in AD pathogenesis and may be helpful as a biomarker for monitoring disease progression.
Journal ArticleDOI
Raised Serum Proinflammatory Cytokines in Alzheimer’s Disease with Depression
Vineet Kumar Khemka,Anirban Ganguly,Debajit Bagchi,Arindam Ghosh,Aritri Bir,Atanu Biswas,Sita Chattopadhyay,Sasanka Chakrabarti +7 more
TL;DR: A strong inverse correlation was observed between the MMSE scores and serum levels of IL-6 or TNF-α in AD subjects with depression and an important role is highlighted in AD associated depression and cognitive deficits.
References
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Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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