Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
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TLDR
The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.About:
This article is published in Biological Psychiatry.The article was published on 2010-11-15. It has received 866 citations till now.read more
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Focus on the Correlations between Alzheimer's Disease and Type 2 Diabetes.
Vincenzo Fiore,Antonia De Rosa,Paolo Falasca,Massimo Marci,Edoardo Guastamacchia,Brunella Licchelli,Vito Angelo Giagulli,Giovanni De Pergola,Antonella Poggi,Vincenzo Triggiani +9 more
TL;DR: In this paper, the authors analyzed common features present in Alzheimer's disease and diabetes mellitus, showing how these two diseases are strictly correlated to each other, including chronic inflammation, oxidative stress, mitochondrial dysfunction, adiponectin deficiency, different expression of plasma cholinesterase activity and vascular damage.
Journal ArticleDOI
Decreased expression of CD33 in peripheral mononuclear cells of Alzheimer's disease patients.
Nan Hu,Meng-Shan Tan,Lei Sun,Teng Jiang,Ying-Li Wang,Lin Tan,Wei Zhang,Jin-Tai Yu,Jin-Tai Yu,Jin-Tai Yu,Lan Tan,Lan Tan,Lan Tan +12 more
TL;DR: According to receiver operating characteristic (ROC) curve analysis, the diagnostic accuracy for CD33 alone is relatively lower, while, combining with additional parameters might further improve the diagnostic value for AD.
Journal ArticleDOI
Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer’s disease
Jagan A. Pillai,Jagan A. Pillai,James Bena,Gurkan Bebek,Lynn M. Bekris,Aaron Bonner-Jackson,Aaron Bonner-Jackson,Lei Kou,Akshay Pai,Lauge Sørensen,Mads Neilsen,Stephen M. Rao,Stephen M. Rao,Mark R. Chance,Bruce T. Lamb,James B. Leverenz,James B. Leverenz +16 more
TL;DR: To determine the inflammatory analytes that predict clinical progression and evaluate their performance against biomarkers of neurodegeneration, a large number of these analytes were found to be related to inflammation.
Journal ArticleDOI
Serum levels of inflammation factors and cognitive performance in amnestic mild cognitive impairment: A Chinese clinical study
TL;DR: It is indicated that IL-6, while not useful alone, has potential in combination with other biomarkers to support early diagnosis of aMCI due to its association with the progression of cognitive impairment.
Journal ArticleDOI
Assessing for unique immunomodulatory and neuroplastic profiles of physical activity subtypes: a focus on psychiatric disorders.
Harris A. Eyre,Bernhard T. Baune +1 more
TL;DR: This systematic review aims to assess the immunomodulatory and neuroplastic profiles of various PA subtypes, particularly in unipolar depression and age-related cognitive decline (ARCD).
References
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Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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