Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
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TLDR
The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.About:
This article is published in Biological Psychiatry.The article was published on 2010-11-15. It has received 866 citations till now.read more
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Journal ArticleDOI
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice
Nasir Javaid,Mahesh Chandra Patra,Daeun Cho,Maria Batool,Yoon Seop Kim,Gwang Muk Choi,Moon Suk Kim,Dae-Hyun Hahm,Sang-Zin Choi +8 more
TL;DR: In this article , a TNF-inhibitory molecule (TIM) was reported to reduce TNF signaling in vitro and was an effective treatment in a mouse model of rheumatoid arthritis.
Posted ContentDOI
A Photonic Biosensor-Integrated Tissue Chip Platform for Real-Time Sensing of Lung Epithelial Inflammatory Markers
John Cognetti,Matthew T Moen,Matthew G. Brewer,Michael Bryan,Joshua D. Tice,James L. McGrath,Benjamin L. Miller +6 more
TL;DR: This work demonstrates the first application of photonic sensors to a human TC device, and will enable new applications in drug development and disease modeling.
Journal ArticleDOI
The Genetic Relationship between Interleukin Genes in AlzheimerâÂÂsDisease
Book ChapterDOI
Pharmacotherapy of Dementia
Sarah A. Chau,Sarah A. Chau,Celina S. Liu,Celina S. Liu,Myuri Ruthirakuhan,Myuri Ruthirakuhan,Krista L. Lanctôt,Krista L. Lanctôt,Nathan Herrmann,Nathan Herrmann,Nathan Herrmann +10 more
TL;DR: Evidence of the safety and efficacy of currently approved drugs and emerging pharmacotherapies in AD is critically examined, including drugs targeting the amyloid-β pathway and pharmacological management of specific neuropsychiatric symptoms.
Psychophysiological, cognitive and behavioral aspects of malnutrition in Alzheimer’s disease: a review
Juliana Sartori Bonini,Vanessa Fernanda Goes,Camilla Fagundes de Oliveira,Andersom Ricardo Fréz,Carla Evelyn Coimbra Nuñez,Pâmela Billig Mello-Carpes,Weber Cláudio Francisco Nunes da Silva +6 more
TL;DR: It is concluded that unfulfilled nutritional needs associated with increased energy demands and various alterations can lead to a rapid, undesirable, and sharp decline in nutritional status in patients with AD.
References
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Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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