Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
Reads0
Chats0
TLDR
The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.About:
This article is published in Biological Psychiatry.The article was published on 2010-11-15. It has received 866 citations till now.read more
Citations
More filters
Journal ArticleDOI
Immune attack: the role of inflammation in Alzheimer disease
TL;DR: As inflammation in AD primarily concerns the innate immune system — unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides — the concept of neuroinflammation in AD may need refinement.
Journal ArticleDOI
Inflammation as a central mechanism in Alzheimer's disease
Jefferson W. Kinney,Shane M. Bemiller,Andrew S. Murtishaw,Amanda M. Leisgang,Arnold Salazar,Bruce T. Lamb +5 more
TL;DR: An overview of inflammation in AD is provided and a detailed coverage of a number of microglia‐related signaling mechanisms that have been implicated in AD are reviewed.
Journal ArticleDOI
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Fangda Leng,Paul Edison +1 more
TL;DR: The interrelationships between Neuroinflammation and amyloid and tau pathologies as well as the effect of neuroinflammation on the disease trajectory in AD are discussed, focusing on microglia as major players in neuro inflammation and how these cells could be modulated as a therapeutic strategy for AD.
Journal ArticleDOI
Microglial priming in neurodegenerative disease.
V. Hugh Perry,Clive Holmes +1 more
TL;DR: The concept of microglial priming, and the subsequent exaggerated response of these cells to secondary systemic inflammation, opens the way to treat neurodegenerative diseases by targeting systemic disease or interrupting the signalling pathways that mediate the CNS response to systemic inflammation.
Journal ArticleDOI
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases.
TL;DR: Current understanding of the involvement of cytokines in neurodegenerative disorders and their potential signaling mechanisms are summarized to suggest that microglial activation and pro-inflammatory cytokines merit interest as targets in the treatment of neurodegnerative disorders.
References
More filters
Journal ArticleDOI
Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease
J-C Lambert,Simon Heath,G Even,Dominique Campion,K. Sleegers,Mikko Hiltunen,O Cambarros,Diana Zelenika,María J. Bullido,Béatrice Tavernier,Luc Letenneur,Karolien Bettens,Claudine Berr,Florence Pasquier,Nathalie Fievet,P Barbager-Gateau,S. Engelborghs,P.P. De Deyn,Ignacio Mateo,A Franck,Seppo Helisalmi,Elisa Porcellini,Olivier Hanon,M de Pancorbo,Corinne Lendon,Carole Dufouil,C Jaillard,Thierry Léveillard,Alvarez,Paolo Bosco,Michelangelo Mancuso,Francesco Panza,Benedetta Nacmias,Paola Bossù,Paola Piccardi,Giorgio Annoni,Davide Seripa,Daniela Galimberti,Didier Hannequin,Federico Licastro,Hilkka Soininen,Karen Ritchie,Hélène Blanché,J. F. Dartigues,Christophe Tzourio,Ivo Gut,Christine Van Broeckhoven,Annick Alpérovitch,P. Amouyel +48 more
Journal ArticleDOI
Microglia as a source and target of cytokines.
TL;DR: Strong responses and modulatory influences can be demonstrated, adding to the emerging view that microglial behavior is highly dependent on the (cytokine) environment and that reactions to a challenge may vary with the stimulation context.
Journal ArticleDOI
Erratum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer (Nature Genetics (2009) 41 (991-995))
Xifeng Wu,Yuanqing Ye,Lambertus A. Kiemeney,Patrick Sulem,Thorunn Rafnar,Giuseppe Matullo,Daniela Seminara,Teruhiko Yoshida,Norihisa Saeki,Angeline S. Andrew,Colin P.N. Dinney,Bogdan Czerniak,Zuo-Feng Zhang,Anne E. Kiltie,D. Timothy Bishop,Paolo Vineis,Stefano Porru,Frank Buntinx,Eliane Kellen,Maurice P. Zeegers,Rajesh Kumar,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Jose I. Mayordomo,Manuel Sanchez,Berta Saez,Annika Lindblom,Petra J. de Verdier,Gunnar Steineck,Gordon B. Mills,Alan R. Schned,Shen Chih Chang,Jie Lin,David W. Chang,Katherine S. Hale,Tadeusz Majewski,H. Barton Grossman,Steinunn Thorlacius,Unnur Thorsteinsdottir,Katja K.H. Aben,J. Alfred Witjes,Kari Stefansson,Christopher I. Amos,Margaret R. Karagas,Jian Gu +45 more
TL;DR: In the version of this article initially published online, Simonetta Guarrera and Silvia Polidoro were inadvertently omitted from the author list, and an affiliation was omitted for Paolo Vineis as mentioned in this paper.
Journal ArticleDOI
Genome-wide analysis of genetic loci associated with Alzheimer disease.
Sudha Seshadri,Annette L. Fitzpatrick,M. Arfan Ikram,Anita L. DeStefano,Vilmundur Gudnason,Mercè Boada,Joshua C. Bis,Albert V. Smith,Minerva M. Carassquillo,Jean-Charles Lambert,Denise Harold,Elisabeth M. C. Schrijvers,Reposo Ramírez-Lorca,Stéphanie Debette,W. T. Longstreth,A. Cecile J.W. Janssens,V. Shane Pankratz,Jean-François Dartigues,Paul Hollingworth,Thor Aspelund,Isabel Hernández,Alexa S. Beiser,Lewis H. Kuller,Peter J. Koudstaal,Dennis W. Dickson,Christophe Tzourio,Richard Abraham,Carmen Antúnez,Yangchun Du,Jerome I. Rotter,Yurii S. Aulchenko,Tamara B. Harris,Ronald C. Petersen,Claudine Berr,Michael John Owen,Jesús López-Arrieta,Badri N. Varadarajan,James T. Becker,Fernando Rivadeneira,Mike A. Nalls,Neill R. Graff-Radford,Dominique Campion,Sanford Auerbach,Kenneth Rice,Albert Hofman,Palmi V. Jonsson,Helena Schmidt,Mark Lathrop,Thomas H. Mosley,Rhoda Au,Bruce M. Psaty,André G. Uitterlinden,Lindsay A. Farrer,Thomas Lumley,Agustín Ruiz,Julie Williams,Philippe Amouyel,Steve G. Younkin,Philip A. Wolf,Lenore J. Launer,Oscar L. Lopez,Cornelia M. van Duijn,Monique M.B. Breteler +62 more
TL;DR: Although CLU and PICALM were confirmed to be associated with AD in this independent sample, they did not improve the ability of a model that included age, sex, and APOE to predict incident AD.
Journal ArticleDOI
Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
Tony Wyss-Coray,Tony Wyss-Coray +1 more
TL;DR: Although there is still little evidence that inflammation triggers or promotes Alzheimer disease, increasing evidence from mouse models suggests that certain inflammatory mediators are potent drivers of the disease.
Related Papers (5)
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more