Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
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TLDR
The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.About:
This article is published in Biological Psychiatry.The article was published on 2010-11-15. It has received 866 citations till now.read more
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Chronic Amyloid β Oligomer Infusion Evokes Sustained Inflammation and Microglial Changes in the Rat Hippocampus via NLRP3.
Csaba Fekete,Csaba Vastagh,Adam Denes,Erik Hrabovszky,Gábor Nyiri,Imre Kalló,Zsolt Liposits,Miklós Sárvári +7 more
TL;DR: Evidence is provided that in response to A βO infusion microglia change their phenotype, but the resulting inflammatory changes are sustained for at least one month after the end of AβO challenge, as well as the role of inflammatory actions in memory deterioration.
Journal ArticleDOI
Anti-ultraviolet radiation effects of Coptis chinensis and Phellodendron amurense glycans by immunomodulating and inhibiting oxidative injury.
TL;DR: C. chinensis and P. amurense glycans dose-dependently significantly increased skin antioxidant enzyme and immunity activities in animals and present photoprotective properties, which can be attributed to molecules, such as flavonoids and carotenoids, which act as UV-absorbing molecules and as antioxidants, as well as stimulate immunity Activities in animals.
Journal ArticleDOI
Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer's Disease.
TL;DR: Altered distribution of elements in the plasma of AD subjects with high interdependencies between elemental levels are demonstrated and the potential of TXRF measurements for disease monitoring is proposed.
Journal ArticleDOI
Treating disorders across the lifespan by modulating cholinergic signaling with galantamine
TL;DR: The involvement of cholinergic mechanisms and inflammation in the pathobiology of Alzheimer's disease, Parkinson's disease and schizophrenia, and the effectiveness of galantamine treatment are summarized.
Journal ArticleDOI
Relationships Among and Predictive Values of Obesity, Inflammation Markers, and Disease Severity in Pediatric Patients with Obstructive Sleep Apnea Before and After Adenotonsillectomy.
Hai-Hua Chuang,Chung-Guei Huang,Chung-Guei Huang,Li-Pang Chuang,Li-Pang Chuang,Yu-Shu Huang,Yu-Shu Huang,Ning-Hung Chen,Ning-Hung Chen,Hsueh-Yu Li,Hsueh-Yu Li,Tuan-Jen Fang,Tuan-Jen Fang,Jen-Fu Hsu,Jen-Fu Hsu,Hsin-Chih Lai,Hsin-Chih Lai,Jau-Yuan Chen,Jau-Yuan Chen,Li-Ang Lee,Li-Ang Lee,Li-Ang Lee +21 more
TL;DR: Investigation of body mass index, serum inflammatory markers, and OSA severity before and after AT in 60 pediatric patients with OSA revealed that age, BMI z-score, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein-1, and RANTES independently predicted surgical cure.
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Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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