Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Environmentally induced epigenetic transgenerational inheritance of disease.
TL;DR: Observations suggest environmentally induced epigenetic transgenerational inheritance of disease is a critical aspect of disease etiology, toxicology and evolution that needs to be considered.
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.
TL;DR: An overview of the basic roles of BET proteins is presented and the pathological functions of BET and the recent developments in cancer therapy targeting BET proteins in animal models are highlighted.
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Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: A systematic review and meta analysis
M. Cissen,Madelon van Wely,I. Scholten,Steven A. Mansell,Jan Bruin,Ben W.J. Mol,Didi D.M. Braat,Sjoerd Repping,Geert Hamer +8 more
TL;DR: There is insufficient evidence to recommend the routine use of sperm DNA fragmentation tests in couples undergoing MAR both for the prediction of pregnancy and for the choice of treatment, according to a systematic review and meta-analysis.
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MicroRNAs and spermatogenesis.
TL;DR: The current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility are discussed.
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Epigenetic regulation of the histone-to-protamine transition during spermiogenesis.
Jianqiang Bao,Mark T. Bedford +1 more
TL;DR: Recent advances in the understanding of how epigenetic players, such as histone variants and histone writers/readers/erasers, rewire the haploid spermatid genome to facilitate histone substitution by protamines in mammals are discussed.
References
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Journal Article
Chromatin structure-function alterations during mammalian spermatogenesis: DNA nicking and repair in elongating spermatids.
S Mcpherson,F J Longo +1 more
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On the nature and origin of DNA strand breaks in elongating spermatids
TL;DR: Transient DNA strand breaks are generated in the whole population of elongating spermatids and are perfectly coincident with histone H4 hyperacetylation at chromatin-remodeling steps, and topoisomerase II appears as the unique enzyme responsible for the transient double-stranded breaks but depends on histone hyper acetylation for its activity.
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Condensation of DNA by Spermatid Basic Nuclear Proteins
TL;DR: Two transition proteins participate in the repackaging of the spermatid genome early in mammalian spermiogenesis, coincident with the first detectable changes in chromatin condensation, and both condense free DNA with rates similar to those of protamine 1 and 2.
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Human sperm chromatin stabilization: a proposed model including zinc bridges.
TL;DR: An alternative model is proposed, that the human spermatozoon could at ejaculation have a rapidly reversible zinc dependent chromatin stability: Zn(2+) stabilizes the structure and prevents the formation of excess disulfide bridges by a single mechanism.
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Mouse protamine 2 is synthesized as a precursor whereas mouse protamine 1 is not.
Pamela C. Yelick,R Balhorn,Paula A. Johnson,M Corzett,J A Mazrimas,Kenneth C. Kleene,Norman B. Hecht +6 more
TL;DR: These studies demonstrated that mP2 is synthesized as a precursor containing 106 amino acids which is processed into the mature, 63-amino-acid form found in spermatozoa.