Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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The intimate genetics of Drosophila fertilization
TL;DR: The current knowledge of fertilization in Drosophila melanogaster is reviewed, with a special emphasis on the genes involved in the complex transformation of the fertilizing sperm nucleus into a replicated set of paternal chromosomes.
Journal ArticleDOI
Rebooting the Epigenomes during Mammalian Early Embryogenesis
Weikun Xia,Wei Xie +1 more
TL;DR: Recent progress in understanding epigenetic reprogramming and their functions during mammalian early development is discussed and the conserved and species-specific principles underlying diverse regulation of the epigenome in early embryos during evolution are highlighted.
Journal ArticleDOI
Impact of sperm DNA chromatin in the clinic
TL;DR: The importance of chromatin packaging in the sperm nucleus as essential for the establishment and maintenance of a viable pregnancy is highlighted.
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Knockout of BRD7 results in impaired spermatogenesis and male infertility
Heran Wang,Ran Zhao,Chi Guo,Shihe Jiang,Jing Yang,Yang Xu,Yukun Liu,Liqing Fan,Wei Xiong,Jian Ma,Shuping Peng,Zhaoyang Zeng,Yanhong Zhou,Xiayu Li,Zheng Li,Xiaoling Li,David C. Schmitt,Ming Tan,Guiyuan Li,Ming Zhou +19 more
TL;DR: Data demonstrate that BRD7 is involved in male infertility and spermatogenesis in mice, andBRD7 defect might be associated with the occurrence and development of human azoospermia.
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Single-cell RNA sequencing of adult mouse testes.
TL;DR: This work presents single-cell RNA sequencing data of 2,500 cells from the testes of two 8-week-old C57Bl/6J mice, which captures the full continuity of the meiotic and postmeiotic stages of spermatogenesis, and is ideally suited for marker discovery, network inference and similar analyses for which temporal ordering of differentiation processes can be exploited.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.