Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Diversity and divergence of dinoflagellate histone proteins
Georgi K. Marinov,Michael Lynch +1 more
TL;DR: The results presented here strongly suggest that transcription through nucleosomal arrays happens in dinoflagellates, consistent with a combination of relaxation of sequence constraints imposed by the histone code and the presence of numerous specialized histone variants.
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The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
TL;DR: A previously unappreciated role of the SETD2-dependent H3K36me3 modification in spermiogenesis is revealed and clues to the molecular mechanisms in epigenetic disorders underlying male infertility are provided.
Journal ArticleDOI
Haploid male germ cells-the Grand Central Station of protein transport.
Christiane Pleuger,Christiane Pleuger,Mari S. Lehti,Mari S. Lehti,Jessica E. M. Dunleavy,Daniela Fietz,Moira K O'Bryan +6 more
TL;DR: It is believed that the continuous and spatiotemporally restrained nature of spermiogenesis provides an outstanding model system to identify, and de-code, cytoskeletal elements and transport mechanisms of relevance to multiple tissues.
Journal ArticleDOI
Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.
TL;DR: TDRD6 within CBs is identified as required for mRNA degradation, specifically the extended 3’ UTR-triggered NMD pathway, and evidence for the requirement of NMD in spermiogenesis is provided.
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Paternal epigenetics: Mammalian sperm provide much more than DNA at fertilization.
TL;DR: This review focuses on the origin and function of the different ncRNAs, demonstrating the importance of these RNAs in embryonic development and transgenerational adaptation to stress and looks at other epigenetic marks, such as DNA methylation or post-translational modifications of histones, which show that they are sensitive to environmental stress and transmissible to offspring.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.