Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Effects of bisphenol A exposure on DNA integrity and protamination of mouse spermatozoa
TL;DR: Bisphenol A is widely used in the manufacture of polycarbonate plastics and has caused increasing concern over its potential adverse impacts on spermatogenesis, but the effect of bispenol A on sarcomaogenesis is yet to be explored.
Journal ArticleDOI
Sex-specific chromatin landscapes in an ultra-compact chordate genome.
Pavla Navratilova,Gemma B. Danks,Abby Long,Stephen Butcher,John Robert Manak,Eric M. Thompson +5 more
TL;DR: Compacted regulatory space in this tunicate genome is accompanied by reduced heterochromatin and chromatin state domain widths, and unusual combinations of histone PTMs with opposing consensus functions are uncovered.
Journal ArticleDOI
Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis
Rohini Bose,Kai Sheng,Kai Sheng,Adel R. Moawad,Adel R. Moawad,Adel R. Moawad,Gurpreet Manku,Gurpreet Manku,Cristian O'Flaherty,Cristian O'Flaherty,Teruko Taketo,Martine Culty,Martine Culty,Martine Culty,Kin Lam Fok,Simon S. Wing,Simon S. Wing +16 more
TL;DR: Huwe1’s critical role as a modulator of the DNA damage response pathway in the earliest steps of spermatogonial differentiation is revealed and a comprehensive survey of the functions of Huwe1 is provided.
Journal ArticleDOI
The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis.
Stefanie M. K. Gärtner,Silke Rothenbusch,Melanie K. Buxa,Ina Theofel,Rainer Renkawitz,Christina Rathke,Renate Renkawitz-Pohl +6 more
TL;DR: In this article, the authors showed that the transition-protein-like protein Tpl94D contains an HMG-box domain and is expressed during chromatin reorganization, which is associated with a remarkable reorganization of the chromatin in post-meiotic stages.
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The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility
TL;DR: The results strongly support the Host Modification model of CI in which Cifs initially modify the paternal and maternal gametes to bestow CI-defining embryonic lethality and rescue.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.