Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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A histone variant condenses flowering plant sperm via chromatin phase separation
Toby Buttress,Shengbo He,Liang Wang,Shaoli Zhou,Lei Sun,Gerhard Saalbach,Martin Vickers,Pilong Li,Xiaoqi Feng +8 more
TL;DR: In this paper, a histone variant, H2B.8, mediates sperm chromatin and nuclear condensation in Arabidopsis thaliana, and a novel mechanism of nuclear compaction via global aggregation of unexpressed chromatin is proposed.
Journal ArticleDOI
Contributions of Flow Cytometry to the Molecular Study of Spermatogenesis in Mammals
TL;DR: In this article, the authors highlight the importance of flow cytometry for the advances on the knowledge of the molecular groundwork of spermatogenesis in mammals, including the characterization of mutant phenotypes, transcriptomics, epigenetic and genomewide chromatin studies, and the attempts to establish cell culture systems for research and/or clinical aims such as infertility treatment.
Testis-specific Protein Kinases TSSK1 and TSSK2 in Mouse Spermiogenesis
TL;DR: It was demonstrated that TSSK1 and T SSK2 are essential for male fertility in mouse, and the homozygous male mutants missing these two kinases are infertile, which makes them potential drug targets for non-hormonal contraceptives.
Posted ContentDOI
Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells
TL;DR: Drosophila Importin-9 functions in female and male meiosis and disrupts the histone to protamine transition during spermiogenesis, requiring the nuclear import of functionally related factors necessary for the completion of gametogenesis.
SMC5/6: Shaping, protecting and preparing the genome for safe reproduction
TL;DR: The aim of this thesis is to gain understanding in the mechanisms that shape, protect and prepare the genome for one of the most complex and challenging, yet essential, processes of species survival: reproduction.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.