Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Environmentally induced epigenetic transgenerational inheritance of disease.
TL;DR: Observations suggest environmentally induced epigenetic transgenerational inheritance of disease is a critical aspect of disease etiology, toxicology and evolution that needs to be considered.
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.
TL;DR: An overview of the basic roles of BET proteins is presented and the pathological functions of BET and the recent developments in cancer therapy targeting BET proteins in animal models are highlighted.
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Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: A systematic review and meta analysis
M. Cissen,Madelon van Wely,I. Scholten,Steven A. Mansell,Jan Bruin,Ben W.J. Mol,Didi D.M. Braat,Sjoerd Repping,Geert Hamer +8 more
TL;DR: There is insufficient evidence to recommend the routine use of sperm DNA fragmentation tests in couples undergoing MAR both for the prediction of pregnancy and for the choice of treatment, according to a systematic review and meta-analysis.
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MicroRNAs and spermatogenesis.
TL;DR: The current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility are discussed.
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Epigenetic regulation of the histone-to-protamine transition during spermiogenesis.
Jianqiang Bao,Mark T. Bedford +1 more
TL;DR: Recent advances in the understanding of how epigenetic players, such as histone variants and histone writers/readers/erasers, rewire the haploid spermatid genome to facilitate histone substitution by protamines in mammals are discussed.
References
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Book Chapter
Protamine Mediated Condensation of DNA in Mammalian Sperm
Rod Balhorn,Monique Cosman,K. Thornton,Viswanathan V Krishnan,M. Corzett,G. Bench,C.E. Kramer,Nicholas V. Hud,M J Allen,M. Prieto,W. Meyer-Ilse,J. Brown,Janos Kirz,X. Zhang,E. Bradbury,G. Maki,R. E. Braun,William G. Breed +17 more
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Nucleosome formation with the testis-specific histone H3 variant, H3t, by human nucleosome assembly proteins in vitro
TL;DR: Results suggest that H3t may be incorporated into chromatin by a specific chaperone-mediated pathway, like the conventional H3.1/H4.
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Stimulation of DNA repair by the spermatidal TP1 protein.
TL;DR: It is reported that TP1 can stimulate the repair of SSB in vitro and demonstrated that in vivo repair of UV‐induced DNA lesions is enhanced in mammalian cells stably expressing TP1.
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The amino acid sequence of a testis-specific basic protein that is associated with spermatogenesis.
TL;DR: The amino acid sequence of the COOH-terminal cyanogen bromide fragment of the testis-specific basic protein of the rat has been determined and the complete sequence of this small, highly basic protein is: (see article for formular).
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The maternal effect mutation sésame affects the formation of the male pronucleus in Drosophila melanogaster.
TL;DR: Immunodetection of lamina antigens indicates that a male pronuclear envelope is able to form around the partially decondensed paternal chromatin, which suggests that the maternally provided sésame(+) function is required for a late stage of sperm chromatin remodeling.