Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Somatic cell nuclear transfer: failures, successes and the challenges ahead.
TL;DR: The most effective improvements in SCNT are reviewed, with a special emphasis on the effect of mitochondrial defects on SCNT embryo/ foetus development, an issue never touched upon before.
Journal ArticleDOI
m6A mRNA modification regulates mammalian spermatogenesis.
Zhen Lin,Ming-Han Tong +1 more
TL;DR: This review summarizes the typical features of m6A RNA modification on mRNA during male germline development, and highlights the function of writers, erasers, and readers of m 6A during mouse spermatogenesis.
Journal ArticleDOI
Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile
Simon Schneider,Melanie Balbach,Jan F. Jikeli,Daniela Fietz,Daniel Nettersheim,Sina Jostes,Rovenna Schmidt,Monika Kressin,Martin Bergmann,Dagmar Wachten,Klaus Steger,Hubert Schorle +11 more
TL;DR: By applying CRISPR/Cas9 mediated gene-editing in oocytes, the Prm2-deficient mouse lines established here clearly demonstrate that mice tolerate loss of one Prm 2 allele, and present an ideal model for further studies on protamine function and chromatin organization in murine sperm.
Journal ArticleDOI
Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health.
TL;DR: This review mainly discusses the relationship between altered epigenetic profiles and reproductive diseases, highlighting how epigenetic defects affect the quality of sperm and embryo.
Journal ArticleDOI
Paternal contribution to development: Sperm genetic damage and repair in fish
María Paz Herráez,Juan Ausió,Alain Devaux,Alain Devaux,Silvia González-Rojo,Cristina Fernández-Díez,Sylvie Bony,Sylvie Bony,Núria Saperas,Vanesa Robles +9 more
TL;DR: This review provides an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization, showing the relationship between the integrity of the diverse elements and the development of a healthy offspring.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.