Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Environmentally induced epigenetic transgenerational inheritance of disease.
TL;DR: Observations suggest environmentally induced epigenetic transgenerational inheritance of disease is a critical aspect of disease etiology, toxicology and evolution that needs to be considered.
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.
TL;DR: An overview of the basic roles of BET proteins is presented and the pathological functions of BET and the recent developments in cancer therapy targeting BET proteins in animal models are highlighted.
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Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: A systematic review and meta analysis
M. Cissen,Madelon van Wely,I. Scholten,Steven A. Mansell,Jan Bruin,Ben W.J. Mol,Didi D.M. Braat,Sjoerd Repping,Geert Hamer +8 more
TL;DR: There is insufficient evidence to recommend the routine use of sperm DNA fragmentation tests in couples undergoing MAR both for the prediction of pregnancy and for the choice of treatment, according to a systematic review and meta-analysis.
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MicroRNAs and spermatogenesis.
TL;DR: The current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility are discussed.
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Epigenetic regulation of the histone-to-protamine transition during spermiogenesis.
Jianqiang Bao,Mark T. Bedford +1 more
TL;DR: Recent advances in the understanding of how epigenetic players, such as histone variants and histone writers/readers/erasers, rewire the haploid spermatid genome to facilitate histone substitution by protamines in mammals are discussed.
References
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Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein.
Christophe Pivot-Pajot,Cécile Caron,Jérôme Govin,Alexandre Vion,Sophie Rousseaux,Saadi Khochbin +5 more
TL;DR: It is observed that recombinant BRDT was capable of inducing reorganization of the chromatin of isolated nuclei in vitro only when the nuclei were from TSA-treated cells, the first demonstration of a large-scale reorganizations of acetylated chromatin induced by a specific factor.
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Remodelling the paternal chromatin at fertilization in mammals.
David W. McLay,Hugh J. Clarke +1 more
TL;DR: Identifying the mechanisms that underlie sperm chromatin remodelling at fertilization may be relevant for understanding reprogramming of somatic cell nuclei after transfer into oocytes and evidence is presented that related proteins may perform similar functions in mammals.
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Histone Ubiquitination and Chromatin Remodeling in Mouse Spermatogenesis
Willy M. Baarends,Jos W. Hoogerbrugge,Henk P. Roest,M. P. Ooms,J. T. M. Vreeburg,Jan H.J. Hoeijmakers,J. Anton Grootegoed +6 more
TL;DR: The postmeiotic uH2A immunoexpression in elongating spermatids indicates that nucleosome destabilization induced by histone ubiquitination may play a facilitating role during histone-to-protamine replacement.
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Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males
TL;DR: The distribution of protamines in sperm obtained from a select group of infertile males producing an elevated level of large sperm heads, in contrast, was different from that of the fertile males.
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Sperm decondensation in xenopus egg cytoplasm is mediated by nucleoplasmin
TL;DR: It is concluded that nucleoplasmin is both necessary and sufficient for the first stage of sperm decondensation in Xenopus eggs.