Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Proteomic analysis reveals the differential histone programs between male germline cells and vegetative cells in Lilium davidii.
Hao Yang,Ning Yang,Tai Wang +2 more
TL;DR: The results suggest that differential histone programs between the germline and companion VCs may be established following the asymmetric division, and are important for identity establishment and differentiation of the male germline as well as the VC.
Journal ArticleDOI
Murine and Human Spermatids Are Characterized by Numerous, Newly Synthesized and Differentially Expressed Transcription Factors and Bromodomain-Containing Proteins
Elisabeth Sabine Klaus,Nicola Helena Gonzalez,Martin Bergmann,Marek Bartkuhn,Wolfgang Weidner,Sabine Kliesch,Christina Rathke +6 more
TL;DR: It is suggested that differentiating spermatids use both common and specific features to open chromatin first for transcription and subsequently for histone-to-protamine transition.
Journal ArticleDOI
Sperm Functional Genome Associated With Bull Fertility.
TL;DR: In this paper, a comprehensive review of sperm functional characteristics or phenotypes associated with bull fertility is provided, which can shed light on additional fertility markers that can be used in combination with scrotal circumference to predict the fertility of breeding bulls.
Journal ArticleDOI
Next generation sequencing of benzo(a)pyrene-induced lacZ mutants identifies a germ cell-specific mutation spectrum.
TL;DR: It is suggested that mutations in sperm can arise via mechanisms that are unique to male germ cells, and differences in error-prone translesion DNA synthesis polymerases may underlie the observed spectrum differences between sperm and bone marrow.
Journal ArticleDOI
A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster.
Emily L Rivard,Andrew G. Ludwig,Prajal H. Patel,Anna Grandchamp,Sarah E. Arnold,Alina Berger,Emilie M. Scott,Brendan J Kelly,Grace C. Mascha,Erich Bornberg-Bauer,Erich Bornberg-Bauer,Geoffrey D. Findlay +11 more
TL;DR: In this paper, the authors conducted a functional genetic screen of over 40 putative de novo genes with testis-enriched expression in Drosophila melanogaster and identified one gene, atlas, required for male fertility.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.