Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
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Histone H2B.8 compacts flowering plant sperm through chromatin phase separation
Toby Buttress,Shengbo He,Liang Wang,Shaoli Zhou,Gerhard Saalbach,Martin Vickers,Guohong Li,Pilong Li,Xiaoqi Feng +8 more
TL;DR: In this paper , a histone variant, H2b.8, mediates sperm chromatin and nuclear condensation in Arabidopsis thaliana, and it is shown that H2B.8 aggregates transcriptionally inactive AT-rich chromatin into phase-separated condensates.
Journal ArticleDOI
An additional marker for sperm DNA quality evaluation in spermatozoa of male partners of couples undergoing assisted reproduction technique (IVF/ICSI): Protamine ratio
TL;DR: The spermatozoa DNA deterioration was closely associated with abnormal protamination but showed an association with the protamine ratio, more than with CMA3 positive, so the P1/P2 ratio might act as an additional biomarker for the evaluation of DNA damage in spermatoozoa.
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A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling.
Claudia Cattoni Rathje,Suzanne J. Randle,Sara Al Rawi,Benjamin M. Skinner,David E. Nelson,Antara Majumdar,Emma Elizabeth Philippa Johnson,Joanne Bacon,Myrto Vlazaki,Nabeel A. Affara,Peter J. I. Ellis,Heike Laman +11 more
TL;DR: It is shown that in addition to the previously known Parkinsonian and hematopoietic phenotypes, male mice with reduced Fbxo7 expression are sterile, and indicates that a defect at the late stages of spermiogenesis, possibly due to faulty spatial dynamics of proteasomes during cytoplasmic remodeling, may underlie the fertility phenotype in mice.
Journal ArticleDOI
Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide.
Suping Xiong,Yanting Li,Yang Xiang,Na Peng,Chunmiao Shen,Yanqiu Cai,Dandan Song,Peng Zhang,Xiaolong Wang,Xuihui Zeng,Xiaoning Zhang +10 more
TL;DR: This study provides a preliminary database of triptolide-induced transcriptome, promotes understanding of the reproductive toxicity of triPTolide, and highlights the need for research on increasing the medical efficacy of tripsolide and decreasing its toxicity.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Proteasome inhibitors: valuable new tools for cell biologists.
Do Hee Lee,Alfred L. Goldberg +1 more
TL;DR: The actions of selective proteasome inhibitors are described, how they can be used to investigate cellular responses, the functions of the proteasomes demonstrated by such studies and their potential applications in the future.
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Book
comprehensive molecular insect science
TL;DR: Includes: Molecular Genetics of Insect Fertilization Sex Determination and the Development of the Genital Disc Dosage Compensation Fat-Cell Development The Juvenile Hormones.