Chromatin dynamics during spermiogenesis.
TLDR
This review highlights the current knowledge on post-meiotic chromatin reorganization and reveals for the first time intriguing parallels in this process in Drosophila and mammals and illustrates the possible mechanisms that lead from a histone-based chromatin to a mainly protamine-based structure during spermatid differentiation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-03-01 and is currently open access. It has received 411 citations till now. The article focuses on the topics: Histone code & Chromatin.read more
Citations
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Environmentally induced epigenetic transgenerational inheritance of disease.
TL;DR: Observations suggest environmentally induced epigenetic transgenerational inheritance of disease is a critical aspect of disease etiology, toxicology and evolution that needs to be considered.
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.
TL;DR: An overview of the basic roles of BET proteins is presented and the pathological functions of BET and the recent developments in cancer therapy targeting BET proteins in animal models are highlighted.
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Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: A systematic review and meta analysis
M. Cissen,Madelon van Wely,I. Scholten,Steven A. Mansell,Jan Bruin,Ben W.J. Mol,Didi D.M. Braat,Sjoerd Repping,Geert Hamer +8 more
TL;DR: There is insufficient evidence to recommend the routine use of sperm DNA fragmentation tests in couples undergoing MAR both for the prediction of pregnancy and for the choice of treatment, according to a systematic review and meta-analysis.
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MicroRNAs and spermatogenesis.
TL;DR: The current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility are discussed.
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Epigenetic regulation of the histone-to-protamine transition during spermiogenesis.
Jianqiang Bao,Mark T. Bedford +1 more
TL;DR: Recent advances in the understanding of how epigenetic players, such as histone variants and histone writers/readers/erasers, rewire the haploid spermatid genome to facilitate histone substitution by protamines in mammals are discussed.
References
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Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Godfried W. van der Heijden,Jürgen Dieker,Alwin A.H.A. Derijck,Sylviane Muller,Jo H. M. Berden,Didi D.M. Braat,Johan van der Vlag,Peter Boer +7 more
TL;DR: The male, in contrast to female G1 chromatin, is uniform and contains predominantly hist one H3.3 as histone H3 variant, while the maternal genome is arrested in meiotic metaphase II.
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Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice
Chunghee Cho,Haesook Jung-Ha,William D. Willis,Eugenia H. Goulding,Paula Stein,Zhe Xu,Richard M. Schultz,Norman B. Hecht,Edward M. Eddy +8 more
TL;DR: It is suggested that development fails because of damage to paternal DNA and that PRM2 is crucial for maintaining the integrity of sperm chromatin.
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The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus
Benjamin Loppin,Emilie Bonnefoy,Caroline Anselme,Anne Laurençon,Timothy L. Karr,Pierre Couble +5 more
TL;DR: It is shown that ssm is a point mutation in the Hira gene, thus demonstrating that the histone chaperone protein HIRA is required for nucleosome assembly during sperm nucleus decondensation, and that nucleosomes containing H3.3, and not H3, are specifically assembled in paternal Drosophila chromatin before the first round of DNA replication.
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The Structural Organization of Sperm Chromatin
TL;DR: The chromatin structure of the human PRM1→ PRM2→ TNP2 domain is examined using a PCR-based assay and shows that this retained, enhanced DNase I sensitive domain reflects an enrichment of histones at discrete regions across the locus.
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Roles of transition nuclear proteins in spermiogenesis
TL;DR: The two TPs appear partly to compensate for each other as both Tnp1 - and Tnp2 -null mice were able to produce offspring, and appear to have largely overlapping functions as the two mutants had similar phenotypes.