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Open AccessJournal ArticleDOI

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Martin Dennis, +1271 more
- 19 Jan 2019 - 
- Vol. 393, Iss: 10168, pp 265-274
TLDR
Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures and these results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
About
This article is published in The Lancet.The article was published on 2019-01-19 and is currently open access. It has received 183 citations till now. The article focuses on the topics: Randomized controlled trial & Modified Rankin Scale.

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Citations
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Journal ArticleDOI

2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association

- 01 Jul 2022 - 
TL;DR: A guideline for the management of patients with spontaneous intra-brachial haemorrhage was proposed by the American Heart Association and American Stroke Association as discussed by the authors . But the guideline does not address the treatment of the patients.
Journal ArticleDOI

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Graeme J. Hankey, +310 more
- 01 Aug 2020 - 
TL;DR: Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures.
Journal ArticleDOI

Encouraging an excitable brain state: mechanisms of brain repair in stroke

TL;DR: Changes in neuronal excitability systems during this period that lead to neural circuit reformation after stroke are reviewed, and how they may be targeted to promote functional recovery is reviewed.
Journal ArticleDOI

Post-stroke Depression Increases Disability More Than 15% in Ischemic Stroke Survivors: A Case-Control Study

TL;DR: The results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment, despite treatment with serotoninergic antidepressants.
References
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Journal ArticleDOI

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment

TL;DR: The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke.
Journal ArticleDOI

Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)

TL;DR: A 5-level version of the EQ-5D has been developed by the EuroQol Group and further testing is required to determine whether the new version improves sensitivity and reduces ceiling effects.
Journal ArticleDOI

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Theo Vos, +699 more
- 08 Oct 2016 - 
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
Journal ArticleDOI

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
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