Epithelial-mesenchymal transition in tumor metastasis.
Kay T. Yeung,Jing Yang +1 more
TLDR
This review provides a summary of both historic and recent studies on the role of EMT in the metastatic cascade from various experimental systems, including cancer cell lines, genetic mouse tumor models, and clinical human breast cancer tissues.About:
This article is published in Molecular Oncology.The article was published on 2017-01-01 and is currently open access. It has received 586 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Circulating tumor cell.read more
Citations
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Guidelines and definitions for research on epithelial–mesenchymal transition
Jing Yang,Parker B. Antin,Geert Berx,Cédric Blanpain,Thomas Brabletz,Marianne E. Bronner,Kyra Campbell,Amparo Cano,Jordi Casanova,Gerhard Christofori,Shoukat Dedhar,Rik Derynck,Heide L. Ford,Jonas Fuxe,Antonio García de Herreros,Gregory J. Goodall,Anna-Katerina Hadjantonakis,Ruby Yun-Ju Huang,Chaya Kalcheim,Raghu Kalluri,Yibin Kang,Yeesim Khew-Goodall,Herbert Levine,Jinsong Liu,Gregory D. Longmore,Sendurai A. Mani,Joan Massagué,Roberto Mayor,David R. McClay,Keith E. Mostov,Donald F. Newgreen,M. Angela Nieto,Alain Puisieux,Alain Puisieux,Raymond B. Runyan,Pierre Savagner,Ben Z. Stanger,Marc P. Stemmler,Yoshiko Takahashi,Masatoshi Takeichi,Eric Theveneau,Jean Paul Thiery,Erik W. Thompson,Robert A. Weinberg,Elizabeth D. Williams,Jianhua Xing,Binhua P. Zhou,Guojun Sheng +47 more
TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.
Journal ArticleDOI
Tumor Antigen Escape from CAR T-cell Therapy.
TL;DR: Antigen escape and downregulation have emerged as major issues impacting the durability of CAR T-cell therapy and ways to overcome these obstacles in order to improve clinical outcomes are explored.
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Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu +10 more
TL;DR: It is proved that circNRIP1 sponges miR-149-5p to affect the expression level of AKT1 and eventually acts as a tumour promotor in GC and demonstrated that quaking can promote circ NRIP1 transcription.
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Mouse models of metastasis: progress and prospects.
TL;DR: The currently available mouse models of metastasis are described, focusing on the mechanistic and therapeutic insights that have been gained by their application, strengths and weaknesses of different models and key technological advances that are generating more refined models.
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EMT: Present and future in clinical oncology.
TL;DR: Current evidences for translational applicability of EMT are evaluated, an overview of the most recent EMT in vivo models, EMT marker analyses in human samples as well as potential EMT therapeutic approaches and ongoing clinical trials are depicted.
References
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Massimo Cristofanilli,G. Thomas Budd,Matthew J. Ellis,Alison Stopeck,Jeri Matera,M. Craig Miller,James M. Reuben,Gerald V. Doyle,W. Jeffrey Allard,Leon W.M.M. Terstappen,Daniel F. Hayes +10 more
TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
Journal ArticleDOI
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
TL;DR: A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).
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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
Amparo Cano,Mirna Perez-Moreno,Isabel Rodrigo,Annamaria Locascio,Maria Blanco,Marta G. del Barrio,Francisco Portillo,M. Angela Nieto +7 more
TL;DR: It is shown that mouse Snail is a strong repressor of transcription of the E-cadherin gene, opening up new avenues for the design of specific anti-invasive drugs.