Forgotten fungi-the gut mycobiome in human health and disease.
Chloe E. Huseyin,Chloe E. Huseyin,Paul W. O'Toole,Paul D. Cotter,Paul D. Cotter,Pauline D. Scanlan +5 more
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TLDR
A comprehensive critique of the methodologies available to research the human mycobiota is provided as well as highlighting the latest research findings from mycological surveys of different groups of interest, which provides new insights and directions for future studies in this burgeoning research area.Abstract:
The human body is home to a complex and diverse microbial ecosystem that plays a central role in host health. This includes a diversity of fungal species that is collectively referred to as our 'mycobiome'. Although research into the mycobiome is still in its infancy, its potential role in human disease is increasingly recognised. Here we review the existing literature available on the human mycobiota with an emphasis on the gut mycobiome, including how fungi interact with the human host and other microbes. In doing so, we provide a comprehensive critique of the methodologies available to research the human mycobiota as well as highlighting the latest research findings from mycological surveys of different groups of interest including infants, obese and inflammatory bowel disease cohorts. This in turn provides new insights and directions for future studies in this burgeoning research area.read more
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
The gut mycobiome of the Human Microbiome Project healthy cohort
Andrea K. Nash,Thomas A. Auchtung,Matthew C. Wong,Daniel P. Smith,Jonathan R. Gesell,Matthew C. Ross,Christopher J. Stewart,Ginger A. Metcalf,Donna M. Muzny,Richard A. Gibbs,Nadim J. Ajami,Joseph F. Petrosino +11 more
TL;DR: The gut mycobiome of the Human Microbiome Project (HMP) cohort was investigated by sequencing the Internal Transcribed Spacer 2 (ITS2) region as well as the 18S rRNA gene, suggesting that it is a more sensitive method for studying the mycoboome of stool samples.
Journal ArticleDOI
The amazing potential of fungi: 50 ways we can exploit fungi industrially
Kevin D. Hyde,Jianchu Xu,Jianchu Xu,Sylvie Rapior,Rajesh Jeewon,Saisamorn Lumyong,Allen Grace Niego,Allen Grace Niego,Pranami D. Abeywickrama,Janith V. S. Aluthmuhandiram,Rashika S. Brahamanage,Siraprapa Brooks,Amornrat Chaiyasen,K. W. Thilini Chethana,Putarak Chomnunti,Clara Chepkirui,Boontiya Chuankid,Nimali I. de Silva,Mingkwan Doilom,Mingkwan Doilom,Mingkwan Doilom,Craig B. Faulds,Eleni Gentekaki,Venkat Gopalan,Pattana Kakumyan,Dulanjalee Harishchandra,Hridya Hemachandran,Sinang Hongsanan,Anuruddha Karunarathna,Anuruddha Karunarathna,Samantha C. Karunarathna,Sehroon Khan,Jaturong Kumla,Ruvishika S. Jayawardena,Jian-Kui Liu,Ning-Guo Liu,Thatsanee Luangharn,Allan Patrick G. Macabeo,Diana S. Marasinghe,Dan Meeks,Peter E. Mortimer,Peter E. Mortimer,Peter Mueller,Sadia Nadir,Sadia Nadir,Karaba N. Nataraja,Sureeporn Nontachaiyapoom,Meghan O’Brien,Watsana Penkhrue,Chayanard Phukhamsakda,Uma Shaanker Ramanan,Achala R. Rathnayaka,Resurreccion B. Sadaba,Birthe Sandargo,Binu C. Samarakoon,Danushka S. Tennakoon,Ramamoorthy Siva,Wasan Sriprom,Trichur S. Suryanarayanan,Kanaporn Sujarit,Nakarin Suwannarach,Thitipone Suwunwong,Benjarong Thongbai,Naritsada Thongklang,De-Ping Wei,S. Nuwanthika Wijesinghe,Jake Winiski,Jiye Yan,Erandi Yasanthika,Marc Stadler +69 more
TL;DR: This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology and provides a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.
Journal ArticleDOI
Bacteriophages of the Human Gut: The “Known Unknown” of the Microbiome
Andrey N. Shkoporov,Colin Hill +1 more
TL;DR: This Review summarizes the available methods and main findings regarding taxonomic composition, community structure, and population dynamics in the human gut phageome, and discusses the main challenges in the field and identify promising avenues for future research.
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