Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Journal ArticleDOI
SARS-CoV-2 infection: Pathogenesis, Immune Responses, Diagnosis
TL;DR: The pathogen phenotype, genotype, replication, pathophysiology, elicited immune response and emerging variants of SARS-CoV-2 and their similarities with other similar viruses are discussed.
Journal ArticleDOI
Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
Abdul Rahman Azizogli,Varun Pai,Francesco Coppola,Roya Jafari,Joseph Dodd-O,Rohan Harish,Bhavani Balasubramanian,Jatin Kashyap,Amanda M. Acevedo-Jake,Petr Král,Vivek Kumar +10 more
TL;DR: In this paper , a combination of molecular docking suites and an existing library of lead-like compounds was used to identify five putative ligand inhibitors of Nsp4, which could present an alternative pharmaceutical approach against SARS CoV-2.
Book ChapterDOI
Herbal Immunomodulators and COVID-19
TL;DR: In this article , the authors describe the therapeutics of plants Phyllanthus emblica, Azadirachta indica, and Swertia chirata in the current scenario against COVID-19.
Journal ArticleDOI
The Clinical and Treatment Challenges Posed by COVID-19
TL;DR: A sound knowledge of all aspects of COVID-19 becomes essential to deal with the aftermaths of this unprecedented pandemic and mental health professionals will have to refresh their knowledge of virology and immunology.
Journal ArticleDOI
Detection of IgG and IgM Levels in Patients with COVID-19 in Mosul Province, Iraq
Hasan F. Kahya,M.T. Mahmood +1 more
TL;DR: Investigation of the profiles of IgG and IgM in 85 patients with confirmed SARS-CoV-2 infection from day 1 after symptom onset until day 35 with 5-day intervals found a significant increase in IgG rate and a significant reduction in IgM rate.
References
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Journal ArticleDOI
Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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