Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Activation and evasion of type I interferon responses by SARS-CoV-2.
Xiaobo Lei,Xiaojing Dong,Ruiyi Ma,Wenjing Wang,Xia Xiao,Zhongqin Tian,Conghui Wang,Ying Wang,Li Li,Lili Ren,Fei Guo,Zhendong Zhao,Zhuo Zhou,Zichun Xiang,Jianwei Wang +14 more
TL;DR: This study shows that Sars-CoV-2 perturbs host innate immune response via both its structural and nonstructural proteins, and thus provides insights into the pathogenesis of SARS-Cov-2.
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Viral and host factors related to the clinical outcome of COVID-19.
Xiaonan Zhang,Yun Tan,Yun Ling,Gang Lu,Feng Liu,Zhigang Yi,Xiaofang Jia,Min Wu,Bisheng Shi,Shuibao Xu,Jun Chen,Wei Wang,Bing Chen,Lu Jiang,Shuting Yu,Jing Lu,Jinzeng Wang,Mingzhu Xu,Zhenghong Yuan,Qin Zhang,Xinxin Zhang,Guoping Zhao,Shengyue Wang,Sai-Juan Chen,Hongzhou Lu +24 more
TL;DR: Clinical data from 326 cases suggest that T cell depletion and cytokine bursts are associated with a worse prognosis, and genomic sequences from 112 patients with confirmed SARS-CoV-2 virus showed two clades with similar virulence and clinical outcome.
Journal ArticleDOI
Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection.
Lu Lin,Xiayang Jiang,Zhenling Zhang,Siwen Huang,Zhenyi Zhang,Zhaoxiong Fang,Zhiqiang Gu,Liangqing Gao,Honggang Shi,Lei Mai,Yuan Liu,Xianqi Lin,Renxu Lai,Zhixiang Yan,Xiaofeng Li,Hong Shan +15 more
TL;DR: GI tract may be a potential transmission route and target organ of SARS-CoV-2, potentially aggravated by various drugs including antibiotics.
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Laboratory diagnosis of emerging human coronavirus infections - the state of the art.
TL;DR: The current laboratory methods available for testing coronaviruses are reviewed by focusing on the coronavirus disease 2019 (COVID-19) outbreak going on in Wuhan, with a focus on the SARS-CoV-2 infections.
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COVID-19: what has been learned and to be learned about the novel coronavirus disease.
TL;DR: This article attempts to provide a timely and comprehensive review of the swiftly developing research subject and will cover the basics about the epidemiology, etiology, virology, diagnosis, treatment, prognosis, and prevention of the disease.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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