Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Book ChapterDOI
Repurposed Drugs Against SARS-CoV-2 Replication in COVID-19
TL;DR: In this article , a large number of anti-viral drugs with their potential efficacy in inhibiting replication of virus by targeting the virus S protein (Spike protein), 3-chymotrypsin-like protease (3CLpro), RNA-dependent RNA polymerase (RdRp), and papainlike proteases (PLpro), which play an important role in the replication cycle and pathogenesis of coronavirus, were assessed as possible treatment options against SARS-CoV-2 infected COVID-19 patients.
Journal Article
Can guggul cure COVID-19 ?
Moni Thomas,Niraj Tripathi +1 more
TL;DR: In this article, the therapeutic and medicinal properties of guggul gum, keeping in mind COVID-19, were reviewed. But the present review focused on the therapeutic properties and not the medicinal properties.
Journal ArticleDOI
Assessment of Persistence Symptoms in Recovered COVID-19 Patients by Yorkshire Rehabilitation Scale (C19‐YRS): A Cross-Sectional Study from Qassim Region, Saudi Arabia
TL;DR: In this article , a descriptive cross-sectional study of 413 confirmed PCR test-positive covid-19 patients enrolled in this study from the Ministry of Health Electronic Surveillance System (HESN).
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): What Can Africa Learn from Ongoing Research in Epidemiology, Clinical Manifestations, Chemotherapy and Prevention?
Silas Lendzele Sevidzem,Aubin Armel Koumba,Christophe Roland Zinga Koumba,Nonvignon Marius Kedote,Gael Darren Maganga,Essé Elvire Agossou,Safiatou Niaré Doumbo,Bitsha-Kitime Dieudoné Kabkia,Luc Djogbenou,Genevieve Lydie Acapovi Yao,Idrissa Sarr,Julien Zahouli Bi Zahouli,Chimène Nze Nkoghé,Rodrigue Mintsa Nguema,Athanase Badolo,Emmanuel Kamba Mebourou,Jacques François Mavoungou,Fatou Bintou Sarr +17 more
TL;DR: All photographs courtesy of AFP, EPA, Getty Images and Reuters.
Journal ArticleDOI
Prevalence and predictors of persistent post-COVID-19 symptoms.
Jose Estrada-Codecido,Adrienne K. Chan,Nisha Andany,Philip W Lam,Melody Nguyen,Ruxandra Pinto,Andrew E. Simor,Nick Daneman +7 more
TL;DR: Persistent symptoms are common and diverse 3 months post-COVID-19 but are likely over-estimated by most reports.
References
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Journal ArticleDOI
Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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