Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Emerging Coronavirus Disease (COVID-19), a pandemic public health emergency with animal linkages: Current status update
Yashpal Singh Malik,Shubhankar Sircar,Sudipta Bhat,O.R. Vinodhkumar,Ruchi Tiwari,Ranjit Sah,Ali A. Rabaan,Alfonso J. Rodriguez-Morales,Kuldeep Dhama +8 more
TL;DR: The current worldwide situation of COVID-2019 is discourse with information on virus, epidemiology, host, the role of animals, effective diagnosis, therapeutics, preventive and control approaches making people aware on the disease outcomes.
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Becoming a Faithful Defender: Traditional Chinese Medicine against Coronavirus Disease 2019 (COVID-19).
TL;DR: Wang et al. as mentioned in this paper reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by traditional Chinese medicine, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like.
Journal ArticleDOI
Epidemiology of COVID-19 in Mexico: from the 27th of February to the 30th of April 2020.
TL;DR: The results indicate the early transmission of COVID-19 in Mexico and a reduction in the number of confirmed cases and a higher mortality rate compared with that of China.
Posted ContentDOI
Early estimation of the risk factors for hospitalisation and mortality by COVID-19 in México
María Fernanda Carrillo-Vega,Guillermo Salinas-Escudero,Carmen García-Peña,Luis Miguel Gutiérrez-Robledo,Lorena Parra-Rodríguez +4 more
TL;DR: It is pointed out that in Mexico, where an important proportion of the population develops two or more chronic conditions simultaneously, high mortality is a sever outcome for those infected by SARS-CoV-2.
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Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection.
Zhuo Zhou,Xinyi Zhang,Xiaobo Lei,Xia Xiao,Tao Jiao,Ruiyi Ma,Xiaojing Dong,Qi Jiang,Wenjing Wang,Yujin Shi,Tian Zheng,Jian Rao,Zichun Xiang,Lili Ren,Tao Deng,Zhengfan Jiang,Zhengfan Jiang,Zhixun Dou,Wensheng Wei,Jianwei Wang +19 more
TL;DR: It is reported that SARSCoV-2 infection activates the innate immune response through the cytosolic DNA sensing cGASSTING pathway, and it is shown that host cells’ self-nucleic acids can be employed as a “danger signal” to alarm the immune system.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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