Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach
Esraa M O. Ismail,Shaza W. Shantier,Mona Salih Mohammed,Hassan Hussein Musa,Wadah J. A. Osman,Ramzi A. Mothana +5 more
TL;DR: In this paper, a number of quinoline and quinazoline alkaloids with antiviral and antimalarial activity were virtually screened against three potential targets for the development of drugs against COVID-19 among seventy-one tested compounds, twenty-three were selected for molecular docking based on their pharmacokinetic and toxicity profiles.
Journal ArticleDOI
Possible Potential Effects of Honey and Its Main Components Against Covid-19 Infection.
Farshid Abedi,Saeedeh Ghasemi,Tahereh Farkhondeh,Mohsen Azimi-Nezhad,Mehdi Shakibaei,Saeed Samarghandian +5 more
TL;DR: In this article, a review of the possible effects of honey and its main components for fighting with SARS-CoV-2 infection is presented, which may indicate that honey may inhibit the entry of the virus into the host cell and its replication as well as modulate the inflammatory cascade.
Journal ArticleDOI
Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach.
Sinead M. O’Donovan,Ali S Imami,Hunter M. Eby,Nicholas D. Henkel,Justin F. Creeden,Sophie Asah,Xiaolu Zhang,Xiaojun Wu,Rawan Alnafisah,R. Travis Taylor,James Reigle,James Reigle,Alexander William Thorman,Behrouz Shamsaei,Jarek Meller,Robert E. McCullumsmith +15 more
TL;DR: In this paper, a bioinformatics workflow was deployed to identify candidate drugs for the treatment of COVID-19 pandemic caused by the novel SARS-CoV-2.
Proceedings ArticleDOI
Designing IoT-Based Independent Pulse Oximetry Kit as an Early Detection Tool for Covid-19 Symptoms
Alfin Hidayat,Subono,Vivien Arief Wardhany,Ajie Setyo Nugroho,Sofyan Hakim,Mirtha Jhoswanda,Ika Noer Syamsiana,Nur Anis Agustina +7 more
TL;DR: This research is focused on the development of pulse oximetry kits by utilizing the Internet of Things (IoT) technology as tools that can be used to perform remote monitoring of covid-19 patients through smartphones with regard to physical and social distancing protocols.
Journal ArticleDOI
Genome Organization of Covid-19 and Emerging Severe Acute Respiratory Syndrome Covid-19 Outbreak: A Pandemic
TL;DR: The objective of EJMO 2020 is to establish a reliable, scalable, scalable and reproducible instrument that can be integrated into the space-time continuum and provide real-time guidance for space-based missions.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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