Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2.
Asim Zahoor Abbasi,Dania Akram Kiyani,Syeda Maira Hamid,Muhammad Saalim,Ammad Fahim,Nasir Jalal +5 more
TL;DR: In this article, the authors investigated the pathogenicity of SARS-CoV-2 and disease susceptibility dependence on the Transmembrane Serine Protease 2 (TMPRSS2) gene as expressed in various population groups.
Journal ArticleDOI
The Role of Human Coronavirus Infection in Pediatric Acute Gastroenteritis.
TL;DR: It has been necessary to pay more attention on gastrointestinal transmission to identify the infected children early and avoid the children without apparent or mild symptoms becoming the sources of infection.
Journal ArticleDOI
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
Shima Makaremi,A. Asgarzadeh,Hamed Kianfar,Ali Mohammadnia,Vahid Asghariazar,Elham Safarzadeh +5 more
TL;DR: In this article , the possible mechanisms and pathways involved in inflammatory immune responses are discussed, and the interleukin (IL-) 1 family cytokines appear to have a strong inflammatory role in severe COVID-19 infection.
Journal ArticleDOI
SARS-CoV-2's origin should be investigated worldwide for pandemic prevention.
Zhiqiang Wu,Qi Jin,Guizhen Wu,Jian Lu,Mingkun Li,Deyin Guo,Ke Lan,Luzhao Feng,Zhaohui Qian,Lili Ren,Wenjie Tan,Wenbo Xu,Weizhong Yang,Jianwei Wang,Chen Wang +14 more
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SARS-CoV-2: Jumping the Species Barrier, Lessons from SARS and MERS, Its Zoonotic Spillover, Transmission to Humans, Preventive and Control Measures and Recent Developments to Counter This Pandemic Virus
Kuldeep Dhama,Shailesh Kumar Patel,Khan Sharun,Mamta Pathak,Ruchi Tiwari,Mohd Iqbal Yatoo,Y. S. Malik,Ranjit Sah,A. A. Rabaan,Parmod Kumar Panwar,K. P. Singh,Izabela Michalak,Wanpen Chaicumpa,D. K. Bonilla-Aldana,Alfonso J. Rodriguez-Morales +14 more
TL;DR: An overview of COVID-19 and the causative virus SARS-CoV-2 is presented, with particular emphasis on the role of animals and their jumping the cross-species barriers, experiences learned from Sars- and MERS-CoVs, zoonotic links, and spillover events, transmission to humans and rapid spread.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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